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Ultracet
Ultracet is a prescription medication used to treat acute pain that is moderate to severe in intensity. It is a combination of two active ingredients: tramadol (an opioid-like pain reliever) and acetaminophen (a non-opioid pain reliever). Tramadol works on the brain to change how your body feels and responds to pain, while acetaminophen helps reduce pain and fever. Ultracet is typically used for short-term pain relief after surgery or injury.
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Frequently Asked Questions
How long does Ultracet take to work?
Ultracet typically starts to relieve pain within 30 minutes to 1 hour after taking a dose.
Can I take Ultracet with other over-the-counter pain relievers?
Avoid taking other medications that contain acetaminophen while using Ultracet to prevent exceeding the daily recommended dose of acetaminophen. If you need additional pain relief, consult your healthcare provider.
Can Ultracet cause addiction?
Yes, Ultracet contains tramadol, which has the potential for abuse, addiction, and dependence. Use the medication only as prescribed and for the shortest duration possible.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember, but if it’s close to your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Is Ultracet safe for long-term use?
No, Ultracet is intended for short-term use due to the risks of addiction, liver damage, and other serious side effects. Consult your healthcare provider for alternative long-term pain management options.
Comprehensive Drug Guide
How Does Ultracet Work?
- Tramadol: A centrally acting analgesic that binds to opioid receptors in the brain and spinal cord to decrease pain perception. It also inhibits the reuptake of serotonin and norepinephrine, which enhances its pain-relieving effects.
- Acetaminophen: A non-opioid analgesic and antipyretic that works by inhibiting the production of prostaglandins, chemicals that cause pain and fever.
Common Dosages
- Tramadol 37.5 mg
- Acetaminophen 325 mg
The typical recommended dose is two tablets every 4 to 6 hours as needed for pain relief, with a maximum of 8 tablets per day.
Typical Dosing
- Take two tablets every 4 to 6 hours as needed for pain. Do not exceed 8 tablets in a 24-hour period.
- Ultracet is typically prescribed for short-term use (5 days or less) due to the risk of dependence, liver damage (from acetaminophen), and other side effects.
Typical Dosing
FDA Approved Indications
- Short-term relief of acute pain that is moderate to severe in intensity.
Who Shouldn't Take Ultracet?
- Severe respiratory depression or compromised breathing.
- Acute alcohol intoxication or use with other central nervous system depressants.
- Severe liver disease or severe kidney disease.
- Known hypersensitivity to tramadol, acetaminophen, or any other component of the medication.
- Patients under the age of 12, due to the risk of serious breathing problems.
Advice From The Pharmacist
- Take Ultracet exactly as prescribed. Do not exceed the recommended dose to avoid serious side effects, such as respiratory depression and liver damage.
- Avoid alcohol and other central nervous system depressants (such as sedatives or muscle relaxants), as they can increase the risk of dangerous side effects.
- Acetaminophen warning: Be cautious about using other over-the-counter medications that contain acetaminophen to avoid exceeding the daily limit of 4,000 mg, as this can cause liver damage.
- Store Ultracet in a secure place to prevent misuse or abuse, especially by children or others in the household.
Side Effects of Ultracet
Common Side Effects
- Drowsiness or dizziness
- Nausea or vomiting
- Constipation
- Dry mouth
- Headache
Uncommon/Severe Side Effects
- Respiratory depression (slow or shallow breathing)
- Liver damage (especially with excessive acetaminophen use)
- Seizures, particularly in patients with a history of seizures or those taking medications that lower the seizure threshold
- Addiction, abuse, or dependence, particularly with long-term use or in individuals with a history of substance abuse
Risks and Warnings of Ultracet
- Respiratory Depression: Tramadol can cause severe respiratory depression, especially at higher doses or when combined with other central nervous system depressants. This is more likely in elderly patients or those with pre-existing breathing problems.
- Liver Damage: Acetaminophen, one of the ingredients in Ultracet, can cause severe liver damage, especially at high doses. Do not exceed the recommended daily dose of acetaminophen (4,000 mg) from all sources.
- Risk of Seizures: Tramadol can increase the risk of seizures, especially in patients with a history of seizures or those taking medications that lower the seizure threshold (e.g., antidepressants, antipsychotics).
- Addiction and Abuse: Ultracet contains tramadol, which can be habit-forming and has a potential for abuse. Use the medication only as prescribed and for the shortest duration necessary.
Interactions with Ultracet
Common Drug Interactions
- Alcohol and CNS depressants: Alcohol, benzodiazepines, and other CNS depressants can enhance the sedative and respiratory-depressant effects of Ultracet.
- Antidepressants (SSRIs, SNRIs, MAOIs): These medications can increase the risk of serotonin syndrome, a potentially life-threatening condition characterized by agitation, confusion, and muscle rigidity.
- Anticoagulants: Acetaminophen can affect the action of blood thinners like warfarin, increasing the risk of bleeding.
Alternatives to Ultracet
- Non-opioid analgesics: Over-the-counter pain relievers like ibuprofen (Advil) or naproxen (Aleve) may be effective for milder pain.
- Tramadol (Ultram): Tramadol alone, without acetaminophen, is another option for managing moderate pain.
- Hydrocodone/Acetaminophen (Norco, Vicodin): Another combination opioid and acetaminophen medication used for short-term pain relief.
- Non-pharmacologic treatments: Physical therapy, hot/cold compresses, or rest may also help alleviate pain depending on the underlying cause.
