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Lortab
Lortab is a combination medication that contains hydrocodone, an opioid pain reliever, and acetaminophen (commonly known as Tylenol), a non-opioid pain reliever. It is used to treat moderate to severe pain and works by reducing the perception of pain in the brain and body. Hydrocodone binds to opioid receptors in the brain to block pain signals, while acetaminophen helps to reduce fever and enhance the pain-relieving effects of hydrocodone.
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Frequently Asked Questions
How long does it take for Lortab to work?
Lortab typically begins to relieve pain within 30 to 60 minutes after taking a dose, with full effects lasting 4 to 6 hours.
Can Lortab be taken with other pain medications?
You should not take Lortab with other medications containing acetaminophen, as this increases the risk of liver damage. If additional pain relief is needed, consult your healthcare provider for safe options.
What should I do if I miss a dose of Lortab?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose as scheduled. Do not double up on doses.
Is Lortab safe for long-term use?
Lortab is generally prescribed for short-term pain relief. Long-term use can lead to tolerance, dependence, or addiction, and should be avoided unless closely monitored by a healthcare provider.
How do I safely stop taking Lortab?
If you have been taking Lortab for a prolonged period, you should not stop suddenly. Gradually tapering the dose under medical supervision is recommended to avoid withdrawal symptoms such as agitation, anxiety, and nausea.
Comprehensive Drug Guide
How Does Lortab Work?
- Hydrocodone binds to opioid receptors in the brain and spinal cord, blocking the transmission of pain signals and altering the brain's response to pain. This provides significant relief from moderate to severe pain.
- Acetaminophen works by inhibiting the production of prostaglandins, chemicals in the body that cause pain and inflammation. It also acts as a fever reducer.
The combination of these two ingredients provides enhanced pain relief, making Lortab effective for conditions such as post-surgical pain, injury, or chronic pain.
Common Dosages
- Hydrocodone: 5 mg, 7.5 mg, or 10 mg
- Acetaminophen: 325 mg, 500 mg, or 650 mg
Typical Dosing
- The typical adult dose of Lortab is one tablet every 4 to 6 hours as needed for pain relief. Dosage is based on the strength of the medication and the patient’s pain severity.
- Do not exceed 4,000 mg of acetaminophen per day to avoid the risk of liver damage.
Typical Dosing
FDA Approved Indications
- Moderate to moderately severe pain in conditions such as injury, surgery, and musculoskeletal disorders
- Acute pain management, especially where non-opioid analgesics alone are insufficient
Who Shouldn't Take Lortab?
- Severe respiratory depression or asthma that is not adequately controlled
- Known hypersensitivity to hydrocodone, acetaminophen, or any other components of the formulation
- Liver disease or hepatic impairment, due to the risk of acetaminophen-induced liver toxicity
- Acute or severe alcoholism or drug dependence
Advice From The Pharmacist
- Take Lortab exactly as prescribed. Do not take more than the recommended dose, as hydrocodone can cause addiction, and acetaminophen in high doses can lead to serious liver damage.
- Avoid drinking alcohol while taking Lortab, as it can increase the risk of liver damage from acetaminophen and increase the risk of respiratory depression from hydrocodone.
- Hydrocodone can cause drowsiness and dizziness. Avoid driving or operating heavy machinery until you know how the medication affects you.
- Take with food or milk to reduce the risk of nausea or stomach upset.
- Do not stop taking Lortab suddenly if you have been using it for an extended period, as this can cause withdrawal symptoms. Tapering the dose under medical supervision is recommended.
Side Effects of Lortab
Common Side Effects
- Drowsiness
- Dizziness
- Nausea
- Vomiting
- Constipation
- Headache
Uncommon/Severe Side Effects
- Respiratory depression (slow or shallow breathing)
- Severe allergic reactions (rash, itching, swelling, difficulty breathing)
- Liver damage (jaundice, dark urine, upper stomach pain)
- Addiction, abuse, or misuse (particularly with long-term use)
Risks and Warnings of Lortab
- Addiction, Abuse, and Misuse: Lortab contains hydrocodone, which has a high potential for addiction. Misuse of Lortab can lead to overdose, death, or dependence. Always take the medication as prescribed.
- Respiratory Depression: Hydrocodone can slow breathing, especially when used in higher doses or when combined with other central nervous system depressants (e.g., alcohol, benzodiazepines).
- Liver Damage: High doses of acetaminophen (more than 4,000 mg per day) can cause severe liver damage. Avoid taking other medications that contain acetaminophen while using Lortab.
- Pregnancy and Breastfeeding: Lortab should be used with caution during pregnancy due to the risk of neonatal opioid withdrawal syndrome. Hydrocodone passes into breast milk and may harm a nursing baby.
Interactions with Lortab
Common Drug Interactions
- Alcohol: Increases the risk of liver damage from acetaminophen and enhances the sedative effects of hydrocodone, leading to increased risk of overdose.
- Benzodiazepines (e.g., diazepam, alprazolam): Increase the risk of respiratory depression when taken with Lortab.
- Antidepressants (e.g., SSRIs, MAO inhibitors): May increase the risk of serotonin syndrome.
- Other medications containing acetaminophen: Increases the risk of acetaminophen overdose.
Alternatives to Lortab
- Percocet (oxycodone/acetaminophen): An opioid combination similar to Lortab, but contains oxycodone instead of hydrocodone.
- Vicodin (hydrocodone/acetaminophen): Another hydrocodone combination, similar to Lortab, but with slightly different formulations.
- Tylenol with Codeine: Combines acetaminophen with a less potent opioid (codeine) for mild to moderate pain relief.
- Non-opioid pain relievers: Ibuprofen (Advil) or naproxen (Aleve) for mild to moderate pain without the risk of opioid-related side effects.
