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Nalocet
Nalocet is a combination medication containing acetaminophen and oxycodone, used for the treatment of moderate to severe pain. Oxycodone is an opioid analgesic that works on the central nervous system to relieve pain, while acetaminophen is a non-opioid pain reliever that helps reduce fever and enhances the pain-relieving effects of oxycodone. Nalocet is typically prescribed when other pain medications are insufficient.
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Frequently Asked Questions
How long does it take for Nalocet to start working?
Nalocet typically begins working within 30 minutes to 1 hour after taking the medication, with peak effects seen at around 1-2 hours.
Can Nalocet cause addiction?
Yes, Nalocet contains oxycodone, which is an opioid and has a high potential for addiction, especially with prolonged use or misuse. It should be used only as prescribed and for the shortest duration necessary.
What should I do if I miss a dose?
If you miss a dose of Nalocet, take it as soon as you remember unless it is almost time for your next dose. Do not take two doses at once to make up for a missed dose.
Can I take Nalocet with ibuprofen?
Yes, Nalocet can be taken with ibuprofen if additional pain relief is needed, as ibuprofen does not contain acetaminophen. However, always consult with your healthcare provider before combining medications.
How can I prevent constipation while taking Nalocet?
To prevent constipation, drink plenty of fluids, eat a high-fiber diet, and consider using a stool softener or fiber supplement. Regular physical activity can also help promote healthy bowel movements.
Comprehensive Drug Guide
How Does Nalocet Work?
- Oxycodone binds to opioid receptors in the brain and spinal cord, altering the perception of pain and the emotional response to it.
- Acetaminophen reduces the production of prostaglandins in the brain, which helps decrease pain and reduce fever. The combination of these two medications provides enhanced pain relief compared to either drug alone.
Common Dosages
- 5 mg oxycodone / 300 mg acetaminophen tablets
Typical Dosing
- The typical starting dose of Nalocet is 1 tablet every 6 hours as needed for pain.
- Do not exceed 4 grams (4000 mg) of acetaminophen per day to avoid liver toxicity, which would be a maximum of 13 Nalocet tablets per day.
- The dosage should be adjusted based on the patient’s pain severity and tolerance to the medication.
Typical Dosing
FDA Approved Indications
- Management of moderate to severe pain where the use of an opioid analgesic is appropriate, and other pain relief options have been ineffective.
Who Shouldn't Take Nalocet?
- Severe respiratory depression or breathing problems.
- Known hypersensitivity to oxycodone, acetaminophen, or any component of the formulation.
- Severe liver impairment due to the risk of acetaminophen-related liver toxicity.
- Acute or severe bronchial asthma in an unmonitored setting or without resuscitative equipment.
Advice From The Pharmacist
- Take Nalocet exactly as prescribed. Do not increase the dose or frequency without consulting your healthcare provider, as this can lead to addiction, overdose, or serious side effects.
- Avoid alcohol while taking Nalocet, as it can increase the risk of liver damage due to acetaminophen and enhance the sedative effects of oxycodone.
- Nalocet may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how the medication affects you.
- Monitor for signs of overdose, which can include extreme drowsiness, slow or difficult breathing, or loss of consciousness. Seek medical help immediately if you suspect an overdose.
- To prevent constipation, a common side effect of opioids, drink plenty of water, and consider using a stool softener or fiber supplement.
Side Effects of Nalocet
Common Side Effects
- Drowsiness or dizziness
- Constipation
- Nausea or vomiting
- Lightheadedness
- Dry mouth
Uncommon/Severe Side Effects
- Respiratory depression: Slowed or difficult breathing, especially in individuals taking high doses or those with underlying lung conditions.
- Severe allergic reactions: Symptoms include rash, itching, swelling, or difficulty breathing.
- Liver damage: Due to acetaminophen, especially if taken in excess or combined with alcohol or other medications that affect the liver.
Risks and Warnings of Nalocet
- Addiction, abuse, and misuse: Nalocet contains oxycodone, which has a high potential for abuse. Misuse of the drug can lead to addiction, overdose, and death, especially when taken in higher doses or without a prescription.
- Respiratory depression: Serious or fatal respiratory depression can occur, especially when starting Nalocet or increasing the dose. Monitor for signs of slow or difficult breathing, and avoid combining Nalocet with other central nervous system depressants like alcohol or sedatives.
- Liver toxicity: Acetaminophen can cause severe liver damage, particularly if doses exceed 4 grams per day. Patients with pre-existing liver conditions should avoid excessive acetaminophen use.
Interactions with Nalocet
Common Drug Interactions
- Alcohol: Avoid alcohol while taking Nalocet, as it increases the risk of liver damage and enhances the sedative effects of oxycodone.
- Central nervous system depressants: Combining Nalocet with benzodiazepines (e.g., Xanax, Valium), sedatives, or other opioids increases the risk of respiratory depression, profound sedation, and overdose.
- MAO inhibitors: These drugs, used for depression or other psychiatric conditions, may interact dangerously with opioids, leading to potentially fatal reactions.
- Other acetaminophen-containing products: Be cautious when taking other medications that contain acetaminophen (e.g., Tylenol), as it may increase the risk of exceeding the safe daily limit of 4 grams of acetaminophen.
Alternatives to Nalocet
- Percocet: Another combination of oxycodone and acetaminophen with similar indications for pain management.
- Vicodin: A combination of hydrocodone and acetaminophen used for moderate to severe pain.
- Non-opioid pain relievers: Such as ibuprofen (Advil) or naproxen (Aleve) for individuals who cannot or prefer not to take opioids.
