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Tigan
Tigan (generic name: trimethobenzamide hydrochloride) is an antiemetic medication used to treat nausea and vomiting. It works by blocking certain signals in the brain that trigger nausea and vomiting. Tigan is often used for nausea caused by surgery, gastrointestinal disorders, or other medical conditions. It is available in capsule and injectable forms.
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Frequently Asked Questions
How quickly does Tigan work?
Tigan generally starts working within 30 to 60 minutes after taking it orally. The injectable form may work faster.
Can I take Tigan with other nausea medications?
Always consult your healthcare provider before combining Tigan with other nausea medications, as this can increase the risk of side effects, such as excessive drowsiness or interactions.
Is Tigan safe to take during pregnancy?
Tigan should be used in pregnancy only if clearly needed and prescribed by a healthcare provider. Discuss the risks and benefits with your doctor if you are pregnant or planning to become pregnant.
What should I do if I miss a dose of Tigan?
If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Can Tigan be used for motion sickness?
Tigan is not typically used for motion sickness. Other medications, such as meclizine or dimenhydrinate, are more commonly recommended for this purpose.
Comprehensive Drug Guide
How Does Tigan Work?
Tigan works by blocking the action of dopamine in the brain, specifically in the chemoreceptor trigger zone (CTZ), which is responsible for controlling nausea and vomiting. By inhibiting dopamine receptors in this area, Tigan helps reduce the urge to vomit.
Common Dosages
- 300 mg oral capsules
- 200 mg/mL solution for intramuscular injection
Typical Dosing
- For nausea and vomiting: The typical adult dose is 300 mg taken orally 3 to 4 times daily as needed. For the injectable form, 200 mg can be administered intramuscularly 3 to 4 times daily as needed.
Typical Dosing
FDA Approved Indications
- Treatment of nausea and vomiting due to various causes, such as post-operative nausea, gastrointestinal disturbances, and other medical conditions.
Who Shouldn't Take Tigan?
- Known hypersensitivity to trimethobenzamide or any of its components
- Severe central nervous system depression
- Liver or kidney impairment (without close monitoring)
Advice From The Pharmacist
- Take Tigan as directed, and do not exceed the prescribed dose. It can be taken with or without food.
- Avoid alcohol while taking Tigan, as it can increase the risk of drowsiness and dizziness.
- If using the injectable form, make sure it is administered by a healthcare provider or someone trained to give injections.
- Be cautious when performing tasks that require alertness, such as driving, as Tigan can cause drowsiness.
Side Effects of Tigan
Common Side Effects
- Drowsiness or dizziness
- Headache
- Diarrhea or constipation
- Blurred vision
- Muscle cramps
Uncommon/Severe Side Effects
- Allergic reactions (rash, itching, swelling, difficulty breathing)
- Severe drowsiness or confusion
- Hypotension (low blood pressure)
- Tremors or muscle rigidity
Risks and Warnings of Tigan
- Central Nervous System Effects: Tigan may cause drowsiness, dizziness, and confusion, particularly in older adults. Use caution when performing tasks that require full mental alertness.
- Liver and Kidney Impairment: Patients with liver or kidney impairment should use Tigan with caution, as it may affect the metabolism and excretion of the drug.
- Allergic Reactions: Severe allergic reactions, although rare, can occur with Tigan. Seek immediate medical attention if symptoms such as rash, swelling, or difficulty breathing develop.
Interactions with Tigan
Common Drug Interactions
- CNS depressants: Combining Tigan with other central nervous system depressants, such as opioids, benzodiazepines, or alcohol, can increase the risk of excessive drowsiness and respiratory depression.
- Antihistamines: Combining Tigan with antihistamines may increase the risk of sedation and dry mouth.
- MAO inhibitors: Tigan should be used cautiously with MAO inhibitors, as it can increase the risk of serious drug interactions.
Alternatives to Tigan
- Ondansetron (Zofran): A serotonin receptor antagonist used for the treatment of nausea and vomiting, particularly for chemotherapy-induced nausea.
- Prochlorperazine (Compazine): Another antiemetic used to treat nausea and vomiting from various causes.
- Metoclopramide (Reglan): Used for the treatment of nausea, vomiting, and delayed gastric emptying.
- Promethazine (Phenergan): An antihistamine that also has antiemetic properties, used for nausea and vomiting.
