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Trimethobenzamide HCl
Trimethobenzamide HCl is an antiemetic medication used to treat nausea and vomiting caused by various conditions, such as gastroenteritis, postoperative nausea, and motion sickness. It is believed to work by affecting the chemoreceptor trigger zone (CTZ) in the brain, which helps to prevent vomiting.
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Frequently Asked Questions
How quickly does trimethobenzamide start working?
Trimethobenzamide typically starts working within 30 to 60 minutes of taking a dose, with effects lasting for several hours.
Can I take trimethobenzamide with food?
Yes, you can take trimethobenzamide with or without food. Taking it with food may help reduce the risk of stomach upset.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember unless it’s close to the time of your next scheduled dose. Do not double the dose to make up for a missed one.
Can trimethobenzamide cause drowsiness?
Yes, drowsiness is a common side effect of trimethobenzamide. Avoid driving or operating heavy machinery until you know how the medication affects you.
Is trimethobenzamide safe during pregnancy?
Trimethobenzamide should only be used during pregnancy if clearly needed and prescribed by your healthcare provider. Discuss the risks and benefits with your doctor.
Comprehensive Drug Guide
How Does Trimethobenzamide HCl Work?
Trimethobenzamide works by inhibiting the chemoreceptor trigger zone (CTZ) in the brain, which is responsible for triggering vomiting in response to certain stimuli. By blocking signals in this region, trimethobenzamide helps to reduce nausea and vomiting.
Common Dosages
- 300 mg oral capsules
- 100 mg/mL injectable solution
Typical Dosing
- For adults, the typical oral dose is 300 mg three to four times daily as needed to control nausea and vomiting.
- For the injectable form, the usual dose is 200 mg intramuscularly, given as needed for acute vomiting.
- Doses may be adjusted based on the severity of symptoms and patient response.
Typical Dosing
FDA Approved Indications
- Treatment of nausea and vomiting due to various causes, including surgery, infection, and gastrointestinal conditions.
Who Shouldn't Take Trimethobenzamide HCl?
- Hypersensitivity to trimethobenzamide or any components of the formulation.
- Severe CNS depression or coma.
- Children in the rectal suppository form (discontinued in the U.S.) due to potential toxicity risks.
Advice From The Pharmacist
- Take trimethobenzamide exactly as prescribed by your healthcare provider.
- Avoid alcohol while taking this medication, as it can increase the risk of side effects like drowsiness and dizziness.
- Do not operate heavy machinery or drive until you know how trimethobenzamide affects you, as it may cause drowsiness or dizziness.
- If using the injectable form, follow proper instructions for administration or ensure that it is administered by a healthcare professional.
- Contact your healthcare provider if symptoms of severe nausea or vomiting persist despite treatment.
Side Effects of Trimethobenzamide HCl
Common Side Effects
- Drowsiness
- Dizziness
- Headache
- Blurred vision
- Diarrhea
Uncommon/Severe Side Effects
- Severe allergic reactions, including rash, itching, or swelling.
- CNS depression or excessive sedation.
- Hypotension (low blood pressure).
- Jaundice (yellowing of the skin or eyes).
Risks and Warnings of Trimethobenzamide HCl
- CNS Depression: Trimethobenzamide can cause drowsiness and dizziness. Avoid activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you.
- Elderly Patients: Older adults may be more sensitive to the sedative effects of trimethobenzamide, increasing the risk of falls or confusion.
- Alcohol: Avoid consuming alcohol while taking trimethobenzamide, as it can enhance the CNS depressant effects, leading to increased drowsiness, dizziness, or impaired coordination.
Interactions with Trimethobenzamide HCl
Common Drug Interactions
- CNS depressants: Combining trimethobenzamide with other medications that cause sedation, such as opioids, benzodiazepines, or alcohol, can increase the risk of CNS depression.
- Anticholinergic medications: Drugs with anticholinergic effects, like antihistamines, may increase the risk of dry mouth, constipation, and urinary retention when taken with trimethobenzamide.
- MAO inhibitors: Caution is advised if trimethobenzamide is taken with MAO inhibitors, as it may increase the risk of side effects.
Alternatives to Trimethobenzamide HCl
- Ondansetron (Zofran): A selective 5-HT3 receptor antagonist used to prevent nausea and vomiting, particularly after chemotherapy or surgery.
- Promethazine (Phenergan): An antihistamine used to treat nausea, vomiting, and motion sickness.
- Metoclopramide (Reglan): A prokinetic agent used to treat nausea, vomiting, and conditions like gastroparesis.
