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Super Bi-Mix
Super Bi-Mix is a compounded injectable medication used to treat erectile dysfunction (ED). It typically contains a combination of papaverine and phentolamine, though it may vary based on the compounding pharmacy. Super Bi-Mix is used as a penile injection to help achieve and maintain an erection by increasing blood flow to the penis. It is prescribed when oral medications like PDE5 inhibitors (e.g., sildenafil or tadalafil) are not effective or suitable.
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Frequently Asked Questions
How long does Super Bi-Mix take to work?
Super Bi-Mix typically works within 5 to 20 minutes after injection, and the effects can last for up to 1 to 2 hours.
Can I inject Super Bi-Mix more than once a day?
No, you should only inject Super Bi-Mix once per day and no more than 3 times per week to avoid the risk of priapism or penile damage.
What should I do if I have an erection lasting longer than 4 hours?
If you experience priapism (an erection lasting more than 4 hours), seek immediate medical attention to prevent permanent damage.
How should I store Super Bi-Mix?
Super Bi-Mix should be stored as directed by the compounding pharmacy, usually in the refrigerator. Always check the instructions provided with the medication.
Is Super Bi-Mix painful to inject?
Most patients report only mild discomfort or a slight burning sensation at the injection site. Proper technique and needle size help minimize pain.
Comprehensive Drug Guide
How Does Super Bi-Mix Work?
Super Bi-Mix works by dilating the blood vessels and relaxing smooth muscles in the penis, which allows increased blood flow. This helps achieve and maintain an erection sufficient for sexual activity. Papaverine and phentolamine act synergistically to maximize blood flow to the penile tissues by directly affecting the vascular system.
Common Dosages
- 0.1 mL to 0.5 mL per injection.
Typical Dosing
- The typical starting dose is usually 0.1 mL to 0.2 mL, injected directly into the corpus cavernosum of the penis (on the side of the shaft).
- The dose may be adjusted depending on the efficacy and tolerability, but the maximum recommended dose should not exceed 1 mL in most cases.
Typical Dosing
FDA Approved Indications
- Erectile dysfunction in men when oral treatments are not effective or contraindicated.
Who Shouldn't Take Super Bi-Mix?
- Penile anatomical abnormalities, such as curvature (Peyronie’s disease).
- Priapism (a history of prolonged erections).
- Known hypersensitivity to any of the components of the compound.
- Conditions predisposing to venous thrombosis or hyperviscosity syndromes.
Advice From The Pharmacist
- Self-injection technique: Make sure to follow proper injection technique as instructed by your healthcare provider. Super Bi-Mix is injected into the side of the penis (corpus cavernosum) using a fine needle.
- Rotate injection sites: To avoid tissue damage or scarring, alternate injection sites between each use.
- Store as directed: Super Bi-Mix may need to be refrigerated depending on the compounding pharmacy’s instructions.
- Monitor for side effects: Contact your healthcare provider if you experience pain, bruising, or prolonged erections.
Side Effects of Super Bi-Mix
Common Side Effects
- Mild pain at the injection site.
- Bruising or swelling at the injection site.
- Erection lasting longer than desired (usually 1 to 2 hours).
Uncommon/Severe Side Effects
- Priapism: An erection lasting longer than 4 hours. This is a medical emergency and requires immediate treatment.
- Penile fibrosis: Repeated use can lead to scar tissue formation, potentially causing penile curvature or erectile difficulties.
- Infection at the injection site if proper technique is not followed.
Risks and Warnings of Super Bi-Mix
- Priapism Risk: Super Bi-Mix increases the risk of priapism (prolonged erection), which can cause permanent damage to the penis if left untreated. Patients should seek medical attention if they have an erection lasting longer than 4 hours.
- Injection Site Reactions: Improper injection technique or frequent use of the same site may cause tissue damage or scarring. Rotating the injection site is essential to avoid these issues.
- Use with Other ED Medications: Super Bi-Mix should not be combined with other medications used to treat erectile dysfunction, such as PDE5 inhibitors (e.g., sildenafil or tadalafil), without guidance from a healthcare provider.
Interactions with Super Bi-Mix
Common Drug Interactions
- Blood pressure medications: Both papaverine and phentolamine can lower blood pressure, so using Super Bi-Mix with antihypertensive medications may increase the risk of hypotension.
- Other ED medications: Using Super Bi-Mix alongside oral erectile dysfunction treatments can increase the risk of priapism or other complications.
- Alpha-blockers: Phentolamine can interact with other alpha-blockers (e.g., tamsulosin) used for treating benign prostatic hyperplasia (BPH), leading to an increased risk of hypotension.
Alternatives to Super Bi-Mix
- Trimix: A more potent combination of papaverine, phentolamine, and alprostadil, used for more severe cases of erectile dysfunction.
- Caverject (Alprostadil): A single-agent injection used to treat erectile dysfunction via direct vasodilation.
- PDE5 Inhibitors: Oral medications such as Viagra (sildenafil) or Cialis (tadalafil) for the treatment of erectile dysfunction.
- Muse (Alprostadil Urethral Suppository): A less invasive alternative where a small suppository is inserted into the urethra.
