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Papaverine HCl
Papaverine HCl is a vasodilator and smooth muscle relaxant derived from the opium poppy. It is primarily used to treat conditions associated with vasospasm and to improve blood flow. Papaverine is commonly utilized in the treatment of erectile dysfunction, as well as in various vascular disorders.
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Frequently Asked Questions
How quickly does Papaverine HCl work?
For erectile dysfunction, papaverine may produce an erection within 5 to 15 minutes after injection, depending on individual response.
Can I use Papaverine HCl with other ED medications?
Consult your healthcare provider before combining papaverine with other erectile dysfunction treatments to avoid potential interactions.
What should I do if I miss a dose?
If you are using papaverine as directed for erectile dysfunction and miss a scheduled dose, follow your healthcare provider’s instructions on how to proceed.
Is Papaverine HCl safe during pregnancy?
Papaverine is not indicated for use in women and should not be used during pregnancy. Consult your healthcare provider for alternatives.
What are the signs of serious side effects to watch for?
Monitor for signs of priapism or severe allergic reactions, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Papaverine HCl Work?
Papaverine works by inhibiting phosphodiesterase, which leads to an increase in cyclic AMP (cAMP) levels in smooth muscle cells. This action causes relaxation of smooth muscles, resulting in vasodilation and increased blood flow to various tissues, including the penis.
Common Dosages
- Injectable solution: Common concentrations include 30 mg/mL.
- Oral tablets: Available in various strengths, typically around 150 mg.
Typical Dosing
- For erectile dysfunction: The recommended dose may vary, but it is typically administered via injection into the penis as directed by a healthcare provider.
- For vascular conditions: The dosage and administration route may vary based on the condition being treated.
Typical Dosing
FDA Approved Indications
- Treatment of erectile dysfunction (often in combination with other therapies).
- Relief of symptoms associated with vascular spasms, such as in conditions affecting peripheral blood flow.
Who Shouldn't Take Papaverine HCl?
- Known hypersensitivity to papaverine or any component of the formulation
- Severe hepatic or renal impairment
- History of priapism or conditions that predispose to prolonged erections
Advice From The Pharmacist
- Use Papaverine HCl exactly as prescribed, and do not exceed the recommended dose.
- If using for erectile dysfunction, follow the healthcare provider’s instructions regarding injection technique and frequency.
- Report any unusual side effects, such as prolonged erections (priapism), to your healthcare provider immediately.
Side Effects of Papaverine HCl
Common Side Effects
- Flushing
- Nausea
- Dizziness
- Local pain or irritation at the injection site
Uncommon/Severe Side Effects
- Priapism (prolonged and painful erection)
- Severe allergic reactions (rash, itching, swelling)
Risks and Warnings of Papaverine HCl
- Priapism: Monitor for signs of prolonged erections, as this can lead to permanent damage if not treated promptly.
- Cardiovascular Risks: Use with caution in patients with cardiovascular disease or conditions that may predispose them to complications.
Interactions with Papaverine HCl
Common Drug Interactions
- Other Antihypertensive Medications: Use with caution, as papaverine can enhance the effects of other blood pressure-lowering medications.
- Alcohol: Avoid excessive alcohol consumption, as it may increase the risk of side effects.
Alternatives to Papaverine HCl
- Other Treatments for Erectile Dysfunction: Such as phosphodiesterase type 5 inhibitors (e.g., sildenafil, tadalafil).
- Other Vasodilators: For conditions requiring improved blood flow, other medications may be considered.
