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SUMAtriptan-Naproxen Sodium
Sumatriptan-Naproxen Sodium is a combination medication used to treat migraine headaches in adults. Sumatriptan is a serotonin receptor agonist (triptan) that helps to relieve migraines by narrowing blood vessels around the brain and reducing substances that trigger pain, nausea, and other migraine symptoms. Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce inflammation and pain associated with migraines. Together, they provide more effective relief than either medication alone.
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Frequently Asked Questions
How quickly does Sumatriptan-Naproxen Sodium work for migraines?
Relief from migraine symptoms typically begins within 30 minutes to 2 hours after taking the first dose of Sumatriptan-Naproxen Sodium.
Can I take Sumatriptan-Naproxen Sodium every day?
No, Sumatriptan-Naproxen Sodium should not be taken daily. It is intended for occasional use during migraine attacks. Overuse can lead to rebound headaches and increased side effects.
Can I take Sumatriptan-Naproxen Sodium with other pain relievers?
You should avoid taking additional NSAIDs (such as ibuprofen or aspirin) with this medication to reduce the risk of gastrointestinal bleeding. However, acetaminophen (Tylenol) may be used if needed, but consult your healthcare provider.
What should I do if I miss a dose?
Sumatriptan-Naproxen Sodium is taken as needed for migraines, so there is no regular dosing schedule. If your symptoms persist after the first dose, you can take a second dose at least 2 hours later, but do not exceed two doses in 24 hours.
Is Sumatriptan-Naproxen Sodium safe during pregnancy?
Sumatriptan-Naproxen Sodium is generally not recommended during pregnancy, particularly in the third trimester, due to the risks associated with NSAIDs like naproxen. Consult your healthcare provider if you are pregnant or planning to become pregnant.
Comprehensive Drug Guide
How Does SUMAtriptan-Naproxen Sodium Work?
- Sumatriptan works by stimulating serotonin receptors in the brain, leading to vasoconstriction (narrowing of blood vessels), which helps relieve the vascular inflammation thought to cause migraines. It also reduces the activity of certain chemicals in the brain that contribute to migraine pain and symptoms.
- Naproxen Sodium works by inhibiting the enzyme cyclooxygenase (COX), which decreases the production of prostaglandins—compounds that cause inflammation, pain, and fever. This reduces the inflammatory pain associated with migraines.
Common Dosages
- 85 mg of sumatriptan / 500 mg of naproxen sodium tablets
Typical Dosing
- For acute migraine: The usual dose is one tablet (85 mg sumatriptan / 500 mg naproxen sodium) taken at the first sign of a migraine. If needed, a second dose can be taken at least 2 hours after the first dose. However, the maximum dose in a 24-hour period should not exceed two tablets.
- Do not use more than two doses in a 24-hour period.
Typical Dosing
FDA Approved Indications
- Acute treatment of migraine attacks with or without aura in adults.
It is not indicated for the prevention of migraines or for treating other types of headaches.
Who Shouldn't Take SUMAtriptan-Naproxen Sodium?
- History of cardiovascular disease, including ischemic heart disease, stroke, or uncontrolled hypertension.
- Allergy to sumatriptan, naproxen, or NSAIDs.
- Active gastrointestinal ulcers or a history of gastrointestinal bleeding.
- Severe liver or kidney impairment.
- Concurrent use of MAO inhibitors or within 14 days of stopping them.
- Use of other triptans or ergotamine within 24 hours.
Advice From The Pharmacist
- Take the medication at the first sign of a migraine for the best effectiveness. Swallow the tablet whole with water and do not crush or chew it.
- Do not take more than two doses (two tablets) within 24 hours.
- Avoid using other NSAIDs (such as ibuprofen or aspirin) while taking this medication, as this can increase the risk of gastrointestinal bleeding.
- Do not use Sumatriptan-Naproxen Sodium for other types of headaches, as it is only indicated for migraine relief.
- Monitor for signs of heart problems, such as chest pain or shortness of breath, especially if you have risk factors for cardiovascular disease.
Side Effects of SUMAtriptan-Naproxen Sodium
Common Side Effects
- Nausea
- Dizziness
- Dry mouth
- Drowsiness
- Fatigue
Uncommon/Severe Side Effects
- Heart attack or stroke: Triptans, including sumatriptan, can increase the risk of cardiovascular events in susceptible individuals.
- Gastrointestinal bleeding: NSAIDs like naproxen can cause stomach ulcers, bleeding, or perforation.
- Serotonin syndrome: A rare but serious condition caused by excess serotonin in the brain, leading to agitation, confusion, rapid heart rate, and muscle rigidity.
- Allergic reactions, including rash, swelling, or difficulty breathing.
Risks and Warnings of SUMAtriptan-Naproxen Sodium
- Cardiovascular Risk: Sumatriptan can cause vasoconstriction of blood vessels, increasing the risk of heart attack or stroke, particularly in patients with a history of cardiovascular disease or uncontrolled high blood pressure. Avoid use in these patients.
- Gastrointestinal Risk: Naproxen can increase the risk of stomach ulcers and gastrointestinal bleeding, particularly with long-term use, in older adults, or in individuals with a history of ulcers.
- Medication Overuse Headache (MOH): Frequent use of migraine medications, including Sumatriptan-Naproxen Sodium, can lead to rebound headaches. Limit use to no more than 2 doses per day or 5 doses per month.
Interactions with SUMAtriptan-Naproxen Sodium
Common Drug Interactions
- Monoamine Oxidase Inhibitors (MAOIs): Sumatriptan should not be used with MAOIs or within 14 days of stopping them.
- Other Triptans/Ergotamine: Avoid using Sumatriptan-Naproxen Sodium with other triptans (like rizatriptan) or ergotamine-containing medications within 24 hours, as this can increase the risk of cardiovascular side effects.
- Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): These antidepressants may increase the risk of serotonin syndrome when taken with sumatriptan.
- Blood thinners: Naproxen can increase the risk of bleeding when taken with anticoagulants or antiplatelet drugs like warfarin or aspirin.
Alternatives to SUMAtriptan-Naproxen Sodium
- Rizatriptan (Maxalt): Another triptan medication used for acute migraine treatment.
- Zolmitriptan (Zomig): A triptan available in both oral and nasal spray forms for migraine relief.
- Eletriptan (Relpax): Another triptan used for migraine treatment.
- Frovatriptan (Frova): A longer-acting triptan often used for treating migraines.
- Ibuprofen or acetaminophen: Non-prescription pain relievers that may be used for mild migraine symptoms.
