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Frova
Frova (frovatriptan) is a triptan used to treat migraine attacks. It is a selective serotonin receptor agonist that works by stimulating serotonin receptors in the brain, which helps to constrict dilated blood vessels and alleviate migraine symptoms. Frova is used to relieve the pain, nausea, and other symptoms associated with migraine headaches.
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Frequently Asked Questions
How quickly does Frova work?
Frova typically begins to work within 1-2 hours after ingestion. It may take longer for some individuals to experience relief.
Can I take Frova if I have high blood pressure?
If you have high blood pressure, consult your healthcare provider before using Frova, as it may not be recommended for individuals with uncontrolled hypertension.
Can I use Frova for migraine prevention?
Frova is indicated for the acute treatment of migraines, not for prevention. Your healthcare provider may suggest other options for migraine prevention if needed.
What should I do if I miss a dose?
Frova is used as needed for acute migraine attacks, so missed doses are not applicable. If you experience frequent migraines, discuss a management plan with your healthcare provider.
Comprehensive Drug Guide
How Does Frova Work?
Frova works by agonizing the 5-HT-1B and 5-HT-1D serotonin receptors. This action leads to the constriction of dilated blood vessels in the brain, which helps to counteract the underlying mechanisms of a migraine. By activating these serotonin receptors, Frova also inhibits the release of pro-inflammatory neuropeptides, which contributes to its effectiveness in alleviating migraine symptoms.
Common Dosages
- Oral tablets: 2.5 mg
Typical Dosing
The typical dosing for Frova is:
- For Migraine Attacks: The usual dose is 2.5 mg taken orally, which can be repeated after 2 hours if needed, with a maximum of 7.5 mg per day.
Typical Dosing
FDA Approved Indications
Frova is FDA-approved for:
- Acute treatment of migraine attacks with or without aura in adults.
Who Shouldn't Take Frova?
- Hypersensitivity: Patients with a known hypersensitivity to frovatriptan or any of its components.
- Cardiovascular Conditions: Patients with a history of ischemic heart disease, uncontrolled hypertension, or stroke.
- Concurrent Use: Patients who are taking or have recently taken monoamine oxidase inhibitors (MAOIs).
Advice From The Pharmacist
- How to Take: Take Frova exactly as prescribed, typically one tablet at the onset of a migraine. Do not exceed the recommended dose.
- Interactions with Food or Alcohol: Frova can be taken with or without food. Avoid excessive alcohol consumption as it may worsen migraine symptoms.
- When to Contact a Healthcare Provider: Contact your healthcare provider if you experience any signs of a serious allergic reaction, chest pain, or if your migraine symptoms do not improve or worsen.
Side Effects of Frova
Common Side Effects
- Dizziness
- Drowsiness
- Nausea
- Dry mouth
Uncommon/Severe Side Effects
- Chest pain or pressure
- Severe allergic reactions (e.g., rash, itching, swelling)
- Symptoms of serotonin syndrome (e.g., confusion, hallucination, seizure, extreme changes in blood pressure)
Risks and Warnings of Frova
- Cardiovascular Risk: Frova may increase the risk of heart attack or stroke, particularly in patients with pre-existing cardiovascular conditions.
- Serotonin Syndrome: Use of Frova with other serotonergic drugs can lead to serotonin syndrome, a potentially life-threatening condition.
- Rebound Headache: Frequent use of migraine medications, including Frova, can lead to rebound headaches or medication overuse headache.
Interactions with Frova
Common Drug Interactions
- Other Triptans: Using Frova with other triptans can increase the risk of adverse effects.
- MAO Inhibitors: Concurrent use with MAO inhibitors can increase the risk of serotonin syndrome.
- SSRIs and SNRIs: Combining Frova with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) may also increase the risk of serotonin syndrome.
Alternatives to Frova
- Sumatriptan (Imitrex)
- Rizatriptan (Maxalt)
- Eletriptan (Relpax)
- Naratriptan (Amerge)
- Acetaminophen or ibuprofen for mild to moderate migraines
