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SUMAtriptan
Sumatriptan is a prescription medication used primarily to treat migraines and cluster headaches.
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Frequently Asked Questions
Can I take sumatriptan if I have heart disease?
If you have a history of heart disease or if you've had a heart attack, you should avoid this medication. It could make these conditions worse.
Does sumatriptan make you sleepy?
Yes, drowsiness is a common side effect of sumatriptan. Exercise caution if you're driving or operating heavy machinery.
I missed a dose of sumatriptan, what should I do?
Sumatriptan is taken as needed for migraines or cluster headaches, so you're not likely to miss a dose. In case you forget, take it as soon as you remember unless it's close to the time of your next dose.
Can I just stop taking sumatriptan after my symptoms are gone?
Unlike other medications, you don't need to taper off sumatriptan. However, discuss with your healthcare provider on how best to manage your migraines.
Will sumatriptan affect my mood?
Sumatriptan isn't known to cause mood changes. But if you're feeling unusual or you have any concerns, don't hesitate to contact your doctor.
Can I have a glass of wine while on sumatriptan?
Alcohol, especially red wine, can trigger migraines. It's best to limit alcohol intake, but if you want to drink, only do so in moderation and discuss with your doctor.
Comprehensive Drug Guide
How Does SUMAtriptan Work?
Sumatriptan is a 5-HT1 receptor agonist, or 'triptan,' which functions as a vasoconstrictor. It achieves its therapeutic effects by binding to 5-HT1B/1D receptors located on intracranial blood vessels and sensory nerves of the trigeminal system.
Common Dosages
- Tablets: 25mg, 50mg, 100mg
- Nasal Spray: 5mg, 20mg
- Injection: 4mg, 6mg
For FDA-approved indications:
- Migraine or cluster headache:
- Oral: 25 to 100mg, may repeat after 2 hours if needed; maximum 200mg/day.
- Injection: 1 to 6mg under the skin, repeated once after one hour if needed; maximum 12mg/day.
- Nasal spray: One 5mg or 20mg spray in one nostril, repeated once after two hours if needed; maximum 40mg/day.
For off-label uses:
- Cyclic vomiting syndrome: 6 mg subcutaneously, may repeat after 1 hour in patients with no or partial response. Max 6 doses/week.
Typical Dosing
FDA Approved Indications
Sumatriptan treats migraines with or without aura, as well as cluster headaches.
Off-Label Uses
Cyclic Vomiting syndrome
Pediatric Dosing
The safety and effectiveness of Sumatriptan in pediatric patients have not been established.
Who Shouldn't Take SUMAtriptan?
- People with a history of, or current, heart conditions.
- Those with uncontrolled high blood pressure.
- Individuals who have had strokes or transient ischemic attacks (TIAs).
- Someone with a peripheral vascular disease.
- Patients with hemiplegic or basilar migraines.
- People who have had an allergic reaction to sumatriptan or other triptans.
Advice From The Pharmacist
- It's effective when taken at the first sign of a migraine; the sooner, the better.
- Limit your intake; no more than 200mg in a day if taken orally
- Be aware; you might feel drowsy, dizzy, or weak after taking this medication. Be careful when driving or doing activities that need concentration.
- Be patient; it may take up to two hours for this medicine to work.
- Inform your doctor immediately if you experience chest pain, a fast or irregular heartbeat, severe stomach pain, or sudden severe headache.
Side Effects of SUMAtriptan
Common Side Effects
- Chest pain or pressure.
- Feeling drowsy, or dizzy.
- Muscle weakness
- Nausea or vomiting
Uncommon/Severe Side Effects
- Seizure.
- Heart attack.
- Stroke.
- Intestinal problems.
- Allergic reactions like rash, itching/swelling, severe dizziness, or difficulty breathing (which need immediate medical attention).
Risks and Warnings of SUMAtriptan
- Consult with your healthcare provider if you're pregnant, planning to become pregnant, or are breastfeeding.
- Exercise caution if you have risks for heart disease.
- Not recommended if you have uncontrolled high blood pressure.
- Not advised to use within 24 hours of another triptan or ergot-type medication.
- Be careful if you're on monoamine oxidase-A inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), or serotonin and norepinephrine reuptake inhibitors (SNRIs) due to the risk of serotonin syndrome.
Interactions with SUMAtriptan
Common Drug Interactions
- SSRIs or SNRIs (antidepressant medications)
- Monoamine oxidase inhibitors (MAOIs)
- Ergotamine (and other ergot alkaloids)
- Other triptans
Common Food Interactions
Research does not suggest any significant food interactions with this medicine; however, migraine patients are advised to maintain a routine with their meals since skipping meals may trigger a migraine.
Alternatives to SUMAtriptan
- Eletriptan
- Rizatriptan
- Zolmitriptan
- Almotriptan
- Frovatriptan
- Naratriptan
- Ubrelvy
- Reyvow
