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Naratriptan HCl

Naratriptan HCl is a medication used for the acute treatment of migraine attacks. It belongs to a class of drugs known as triptans, which are specifically designed to relieve migraine symptoms by constricting blood vessels in the brain and inhibiting the release of pro-inflammatory neuropeptides.



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Frequently Asked Questions

How quickly does Naratriptan HCl work?
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Naratriptan typically begins to relieve migraine symptoms within 1 to 3 hours after administration.

Can I take Naratriptan HCl with food?
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Yes, it can be taken with or without food.

What should I do if I miss a dose?
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Naratriptan is intended for use at the onset of a migraine attack; therefore, there is no scheduled dosing. If you miss a dose during a migraine, take it as soon as you remember. Do not take it if it's close to the time of your next dose.

Are there any dietary restrictions while using Naratriptan HCl?
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There are no specific dietary restrictions while using Naratriptan HCl.

Is Naratriptan HCl safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Naratriptan HCl during these periods.

Comprehensive Drug Guide

How Does Naratriptan HCl Work?

Naratriptan works by agonizing serotonin (5-HT) receptors in the brain, particularly the 5-HT_1B and 5-HT_1D receptors. This action leads to vasoconstriction of dilated intracranial blood vessels and reduces the release of pro-inflammatory substances, thereby alleviating migraine symptoms.



Common Dosages

  • Tablets: Common strengths include 1 mg and 2.5 mg.

Typical Dosing

  • The usual recommended dose is 1 mg to 2.5 mg taken orally at the onset of a migraine attack. A second dose may be taken after 4 to 6 hours if the migraine persists, but not more than 5 mg in a 24-hour period.


Typical Dosing

FDA Approved Indications

  • Migraine: for the acute treatment of migraine attacks, with or without aura.


Who Shouldn't Take Naratriptan HCl?

  • Known hypersensitivity to naratriptan or any component of the formulation.
  • History of ischemic heart disease, cerebrovascular disease, or uncontrolled hypertension.
  • Concurrent use of monoamine oxidase inhibitors (MAOIs).


Advice From The Pharmacist

  • Take Naratriptan HCl as soon as a migraine attack begins for optimal effectiveness.
  • Do not exceed the recommended dose and avoid taking it within 24 hours of another triptan.
  • If migraines are not relieved after the first dose or if they worsen, consult your healthcare provider.


Side Effects of Naratriptan HCl

Common Side Effects

  • Dizziness
  • Drowsiness
  • Fatigue
  • Nausea
  • Dry mouth


Uncommon/Severe Side Effects

  • Chest pain or tightness
  • Severe allergic reactions (rash, itching, swelling)


Risks and Warnings of Naratriptan HCl

  • Cardiovascular Risks: Triptans can cause vasoconstriction; use with caution in patients with risk factors for cardiovascular disease.
  • Medication Overuse: Frequent use of migraine medications can lead to rebound headaches.


Interactions with Naratriptan HCl

Common Drug Interactions

  • Other Triptans: Do not use naratriptan within 24 hours of another triptan due to increased risk of side effects.
  • MAOIs: Concurrent use with MAOIs can increase the risk of serotonin syndrome.


Alternatives to Naratriptan HCl

  • Other Triptans: Such as sumatriptan or rizatriptan for acute migraine treatment.
  • Preventive Treatments: Medications like beta-blockers or anticonvulsants may be used for migraine prevention.