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Amerge
Amerge (generic name: naratriptan) is a serotonin receptor agonist (also known as a triptan) used for the acute treatment of migraine attacks with or without aura in adults. It works by narrowing blood vessels around the brain and reducing substances in the body that trigger migraine symptoms like pain, nausea, and sensitivity to light or sound. Amerge is not used to prevent migraines but helps alleviate symptoms once they start.
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Frequently Asked Questions
How long does it take for Amerge to start working?
Amerge typically starts working within 1 to 2 hours of taking the tablet. Some patients may experience relief sooner.
Can I take Amerge to prevent migraines?
No, Amerge is not intended for the prevention of migraines. It is used to treat acute migraine attacks once they have started.
What should I do if my migraine returns after taking Amerge?
If your migraine symptoms return after the first dose, you may take a second dose after at least 4 hours. Do not exceed 5 mg of Amerge in a 24-hour period.
Can Amerge be taken with over-the-counter pain relievers?
You should consult your healthcare provider before combining Amerge with other medications, but it is generally safe to use with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or acetaminophen.
Is Amerge safe during pregnancy?
There is limited information on the safety of Amerge during pregnancy. You should consult your healthcare provider before using Amerge if you are pregnant or planning to become pregnant.
Comprehensive Drug Guide
How Does Amerge Work?
Amerge works by stimulating serotonin (5-HT1) receptors in the brain, which causes constriction of blood vessels. This action reduces the swelling and pressure on nerves associated with migraine attacks, providing relief from headache pain and other symptoms like nausea, light sensitivity, and aura.
Common Dosages
- Tablets: 1 mg and 2.5 mg
Typical Dosing
- The usual dose for treating a migraine attack is 1 mg or 2.5 mg, taken orally as soon as the migraine symptoms begin. If the symptoms persist or return, a second dose can be taken after 4 hours, but the total dose should not exceed 5 mg in a 24-hour period.
- Amerge should only be used for acute treatment and not for chronic prevention of migraines.
Typical Dosing
FDA Approved Indications
- The acute treatment of migraine attacks with or without aura in adults.
Off-Label Uses
Who Shouldn't Take Amerge?
- Uncontrolled hypertension
- History of stroke or transient ischemic attack (TIA)
- Ischemic heart disease or other heart conditions
- Severe liver or kidney impairment
Advice From The Pharmacist
- Take Amerge at the first sign of a migraine for the best results.
- Do not take Amerge within 24 hours of using other migraine medications like ergotamine or other triptans.
- Avoid using Amerge if you have cardiovascular conditions or are at risk for heart disease without consulting your healthcare provider.
- Amerge may cause drowsiness, so avoid driving or operating heavy machinery until you know how the medication affects you.
Side Effects of Amerge
Common Side Effects
- Drowsiness or fatigue
- Dizziness
- Nausea
- Dry mouth
Uncommon/Severe Side Effects
- Chest pain or tightness
- Shortness of breath
- Irregular heartbeat
- Severe allergic reactions (such as swelling or difficulty breathing)
Risks and Warnings of Amerge
- Cardiovascular Risk: Triptans, including Amerge, may cause narrowing of blood vessels, which can increase the risk of heart attack or stroke in patients with cardiovascular disease. Patients with known heart conditions should avoid using Amerge without close monitoring by a healthcare provider.
- Medication Overuse Headache: Using Amerge too frequently can lead to medication overuse headaches, where migraines become more frequent or severe.
Interactions with Amerge
Common Drug Interactions
- Other Triptans or Ergotamine: Using Amerge with other triptans or ergotamine-containing medications within 24 hours may increase the risk of serious cardiovascular side effects.
- SSRIs/SNRIs: The use of Amerge with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) may increase the risk of serotonin syndrome, a potentially life-threatening condition.
- MAO Inhibitors: Avoid taking Amerge if you are using monoamine oxidase inhibitors (MAOIs), as these can increase the risk of severe side effects.
Alternatives to Amerge
- Sumatriptan (Imitrex): Another triptan used for acute migraine treatment, available in oral, nasal, and injectable forms.
- Rizatriptan (Maxalt): A triptan with a faster onset of action compared to Amerge.
- Zolmitriptan (Zomig): Available in oral, nasal, and dissolvable tablet forms for the acute treatment of migraines.
- Over-the-counter NSAIDs: Medications like ibuprofen or naproxen may be used for less severe migraine attacks.
- Anti-nausea medications: Drugs like metoclopramide can help alleviate nausea associated with migraines.
