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Naproxen Sodium

Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is commonly prescribed for conditions such as arthritis, muscle pain, tendonitis, dental pain, and menstrual cramps.



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Frequently Asked Questions

How quickly does naproxen sodium work?
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Naproxen sodium typically starts to relieve pain within 30 minutes to 1 hour, with maximum effects often seen within a few hours.

Can I take naproxen sodium with food?
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Yes, taking naproxen sodium with food or milk can help reduce gastrointestinal irritation.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.

Are there any dietary restrictions while using naproxen sodium?
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There are no specific dietary restrictions, but maintaining a balanced diet is advisable.

Is naproxen sodium safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using naproxen sodium, particularly in the third trimester, as it may pose risks to the fetus.

Comprehensive Drug Guide

How Does Naproxen Sodium Work?

Naproxen sodium works by inhibiting the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which play a key role in the synthesis of prostaglandins—compounds involved in the inflammatory response, pain, and fever. By reducing the production of prostaglandins, naproxen sodium alleviates pain and inflammation.



Common Dosages

  • Tablets: 220 mg and 550 mg.
  • Liquid Suspension: 125 mg/5 mL.

Typical Dosing

  • For acute pain: The usual initial dose is 500 mg, followed by 250 mg every 6 to 8 hours as needed, not to exceed 1,250 mg in the first day.
  • For arthritis: The recommended dose is usually 250 mg to 500 mg twice daily, based on individual response.


Typical Dosing

FDA Approved Indications

  • Acute Pain: including conditions like headache, dental pain, and menstrual cramps.
  • Chronic Pain: associated with conditions such as arthritis, ankylosing spondylitis, and tendinitis.
  • Fever Reduction: to help lower fever.


Who Shouldn't Take Naproxen Sodium?

  • Known hypersensitivity to naproxen or other NSAIDs.
  • Active gastrointestinal bleeding or peptic ulcer disease.
  • Severe kidney or liver disease.


Advice From The Pharmacist

  • Take naproxen sodium with food or milk to help minimize gastrointestinal irritation.
  • Avoid taking other NSAIDs concurrently unless directed by a healthcare provider.
  • Monitor for signs of gastrointestinal bleeding (e.g., black or bloody stools) and report them immediately.


Side Effects of Naproxen Sodium

Common Side Effects

  • Upset stomach or indigestion
  • Dizziness
  • Headache
  • Drowsiness
  • Rash


Uncommon/Severe Side Effects

  • Gastrointestinal bleeding
  • Kidney problems (symptoms include decreased urine output or swelling)
  • Severe allergic reactions (rash, itching, swelling)


Risks and Warnings of Naproxen Sodium

  • Gastrointestinal Risk: NSAIDs can increase the risk of serious gastrointestinal events; use the lowest effective dose for the shortest duration necessary.
  • Cardiovascular Risk: Long-term use may increase the risk of heart attack or stroke; monitor patients with existing cardiovascular conditions.
  • Kidney Effects: Use with caution in patients with pre-existing kidney disease or those on diuretics.


Interactions with Naproxen Sodium

Common Drug Interactions

  • Anticoagulants: Increased risk of bleeding when taken with blood thinners (e.g., warfarin).
  • Other NSAIDs: Avoid combining with other NSAIDs to reduce the risk of gastrointestinal side effects.


Alternatives to Naproxen Sodium

  • Other NSAIDs: Such as ibuprofen or ketoprofen for similar indications.
  • Acetaminophen: As an alternative for pain relief if NSAIDs are contraindicated.