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Glumetza
Metformin ER is an oral antidiabetic medication that's the first line of treatment for type 2 diabetes. It's known to lower blood sugar levels by improving the way your body handles insulin, suppressing glucose production in the liver, and making your body more sensitive to insulin.
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Frequently Asked Questions
Can I take Metformin if I have kidney disease?
No, metformin is generally not recommended if you have severe kidney disease. Your doctor can guide you on other alternatives.
Does Metformin cause weight loss?
Yes, metformin may cause weight loss by reducing hunger and making you feel full for a longer period.
I missed a dose of Metformin, what should I do?
Take it as soon as you remember. But if it s close to your next dose, skip the missed one. Do not take an extra dose to make up for the missed dose.
Can I just stop taking Metformin suddenly?
Stopping metformin abruptly could lead to high blood sugar levels. Always talk to your doctor before discontinuing it.
Are there any dietary restrictions while on Metformin?
Eating healthy is the first step in controlling diabetes. Limit consumption of unhealthy foods that cause your blood sugar to spike. Remember to be cautious about alcohol intake.
Comprehensive Drug Guide
How Does Glumetza Work?
Metformin is a biguanide antidiabetic agent that enhances insulin sensitivity, inhibits hepatic gluconeogenesis, and reduces the amount of sugar absorbed by the intestines.
What is Glumetza Used For?
FDA indications: Metformin is used as an adjunct to diet and exercise to improve glycemic control in adults and children with type 2 diabetes mellitus.
Off-label uses: It's also used in the treatment of polycystic ovary syndrome (PCOS) and has shown some promise in the prevention of gestational diabetes.
Common Dosages
Tablets: 500mg, 850mg, 1000mg,
Extended-release tablets: 500mg, 750mg, 1000mg
Oral solution: 100mg/mL
Typical Dosing
FDA Approved Indications
- For FDA-approved indications:
- Type 2 Diabetes: 500mg to 2550mg daily in divided doses, depending on the patient?s response.
Off-Label Uses
- For off-label uses:
- PCOS: 1,500mg to 2,000mg daily in divided doses.
- Gestational diabetes prevention: Dosage will vary, and is determined by the healthcare provider.
Who Shouldn't Take Glumetza?
- People with kidney or liver disease.
- Individuals with heart conditions or heart failure.
- People with a metabolic condition called metabolic acidosis.
- People with a history of allergic reactions to metformin or other ingredients in the medicine.
- Pregnant women or women who are breastfeeding, unless their doctor deems it necessary.
- Individuals with alcohol addiction or who consume alcohol regularly.
Advice From The Pharmacist
- - Take the medicine with meals, either during or immediately after, to decrease stomach upset.
- - Stay hydrated, especially when exercising or in hot weather, to prevent dehydration and lactic acidosis.
- - Be cautious about alcohol consumption, as it can increase the risk of lactic acidosis.
- - Regular blood tests will be needed to check your blood sugar levels, kidney function, and other important parameters.
- - Remember to continue eating healthy and exercising to achieve the full benefits of the medication.
- - And don't stop taking metformin unless your doctor tells you to. Abrupt stoppage can lead to a flare in blood sugar levels.
Side Effects of Glumetza
Common Side Effects
- - Stomach upset, diarrhea, and feeling bloated.
- - Metallic taste in your mouth.
- - Loss of appetite which may cause weight loss.
Uncommon/Severe Side Effects
- - Rare, but severe side effects:
- - Lactic acidosis, a serious metabolic condition, which may cause trouble breathing, stomach pain, or feeling weak or tired.
- - Low vitamin B12 levels, which might lead to anemia or peripheral neuropathy.
- - If you have nausea, vomiting, rapid breathing, or any other unusual symptoms, seek immediate medical help.
Risks and Warnings of Glumetza
- Understand that Metformin, despite its many benefits, is not suitable for everyone. People with kidney or liver diseases or heart conditions need to be careful while considering Metformin.
- Those suffering from alcohol addiction must be under close medical supervision while on this medication.
- Metformin should be used under the guidance of a healthcare provider during pregnancy or breastfeeding. It's still unclear if it could harm the baby.
- Long-term use of Metformin could lead to Vitamin B12 deficiency causing anemia and nerve problems.
- Lactic acidosis, a rare but serious metabolic complication, could occur in very sick or dehydrated people.
Interactions with Glumetza
Common Drug Interactions
- Certain blood pressure drugs (like furosemide, and nifedipine)
- Heart drugs (like digoxin, dofetilide)
- HIV drugs (like ritonavir)
- Other diabetes drugs (like insulin, glipizide)
- Steroids (like prednisone)
- Thyroid drugs (like levothyroxine)
- Birth control pills
Alternatives to Glumetza
- Sulfonylureas: Glipizide, Glyburide
- Meglitinides: Repaglinide, Nateglinide
- Thiazolidinediones: Rosiglitazone, Pioglitazone
- DPP-4 inhibitors: Sitagliptin, Linagliptin
- SGLT2 inhibitors: Dapagliflozin, Canagliflozin
