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Dofetilide
Dofetilide is an antiarrhythmic medication used to treat certain types of serious irregular heartbeat (such as persistent atrial fibrillation/tachycardia). It works by restoring normal heart rhythm and maintaining a regular, steady heartbeat. Dofetilide can greatly decrease the risk of fatal heart rhythm problems. Side effects are rare but can include headache, dizziness, and, in rare cases, kidney problems.
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Frequently Asked Questions
Can I stop taking Dofetilide if I feel better?
No, always consult your healthcare provider before making any changes to how you take your medication.
What should I do if I miss a dose?
Take the missed dose as soon as you remember. If it's nearly time for your next dose, skip the missed dose. Do not take two doses at one time.
Will Dofetilide affect my lifestyle?
Some patients report feeling dizzy or fatigued while taking Dofetilide. Always tell your doctor about any side effects you experience.
Is Dofetilide safe to take during pregnancy?
While the effects of Dofetilide during pregnancy are unknown, it is recommended to consult with your healthcare provider before starting this medication if you're pregnant or planning to get pregnant.
Comprehensive Drug Guide
How Does Dofetilide Work?
Dofetilide is a class III antiarrhythmic agent that blocks the rapid component of the delayed rectifier outward potassium current.
What is Dofetilide Used For?
FDA indications: Dofetilide is used to maintain normal sinus rhythm in patients with atrial fibrillation or atrial flutter.
Off-label uses: Off-label, Dofetilide has been used to treat ventricular tachycardia, though this is not a standard practice.
Common Dosages
Capsules: 125 micrograms, 250 micrograms, 500 micrograms
Typical Dosing
FDA Approved Indications
- Adult: Initial dose: 500 mcg orally every 12 hours
- Renal function and QTc should be re-evaluated after the initial dosing
- Dose may be reduced if QT is prolonged
Who Shouldn't Take Dofetilide?
- Those with kidney problems or on dialysis should not take Dofetilide.
- People with specific heart conditions, such as long QT syndrome, should also avoid this medication.
- Although it is unclear, pregnant or nursing patients should consult their healthcare provider before taking this drug.
- Those with severe liver disease should not take Dofetilide.
Advice From The Pharmacist
- - Take Dofetilide as prescribed by your healthcare provider, even if you feel well.
- - Your healthcare provider will monitor your heart rhythm regularly while you are taking this medication.
- - Do not stop taking Dofetilide without your doctor's approval.
- - Remember to take Dofetilide at the same time every day.
- - Notify your doctor immediately if you experience palpitations or feel faint while on this medication.
- - If you miss your dose and it's close to the time of your next dose, skip the missed dose; don't double up.
- - Dofetilide can cause dizziness, avoid driving and tasks requiring alertness until you know how the drug affects you.
Side Effects of Dofetilide
Common Side Effects
- - The most common side effects include a headache, chest pain, and respiratory tract infections.
Uncommon/Severe Side Effects
- - In rare cases, Dofetilide use may lead to a condition that affects the heart rhythm (QT prolongation).
- - Contact a healthcare provider immediately if you feel faint, lightheaded, or have a fast heartbeat.
Risks and Warnings of Dofetilide
- Dofetilide should be avoided in people with certain heart conditions such as long QT or severe kidney disease.
- Given its potential to affect pregnancy, this medication should only be used in pregnancy if the potential benefit outweighs the risk.
- Uncontrolled potassium levels in the blood can potentially lead to serious (sometimes fatal) irregular heartbeat. Follow your doctor's instructions about restricting your diet and the use of potassium supplements.
- People taking Dofetilide should abstain from taking drugs that might lead to renal damage, such as certain antibiotics.
- For the elderly, risks might outweigh the benefits due to age-related kidney damage.
Interactions with Dofetilide
Common Drug Interactions
- Verapamil
- Ketoconazole
- Trimethoprim
- Prochlorperazine
- Hydrochlorothiazide
Alternatives to Dofetilide
- Amiodarone
- Sotalol
- Ibutilide
- Flecainide
- Propafenone
