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NIFEdipine
NIFEdipine is a calcium channel blocker primarily used for the treatment of hypertension (high blood pressure) and angina pectoris (chest pain). It helps relax and widen blood vessels, which improves blood flow and reduces the workload on the heart.
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Frequently Asked Questions
How quickly does NIFEdipine work?
NIFEdipine may start to lower blood pressure within 1 to 2 hours, but it may take several weeks for the full effects to be seen.
Can I take NIFEdipine with food?
Yes, NIFEdipine can be taken with or without food; however, consistency is important.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using NIFEdipine?
There are no specific dietary restrictions, but it is advisable to limit grapefruit juice.
Is NIFEdipine safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using NIFEdipine during these periods.
Comprehensive Drug Guide
How Does NIFEdipine Work?
NIFEdipine works by blocking calcium entry into vascular smooth muscle and cardiac muscle cells. This inhibition leads to relaxation of the smooth muscle, resulting in vasodilation, decreased peripheral resistance, and reduced myocardial oxygen demand.
Common Dosages
- Immediate-Release Capsules: 10 mg and 20 mg.
- Extended-Release Tablets: 30 mg, 60 mg, and 90 mg.
Typical Dosing
- For hypertension: The usual starting dose is 30 mg once daily for extended-release formulations. For immediate-release forms, the initial dose may be 10 mg three times daily.
- For angina: Dosage may vary based on individual response and clinical condition.
Typical Dosing
FDA Approved Indications
- Hypertension: for the treatment of high blood pressure.
- Angina Pectoris: for the management of chronic stable angina.
Who Shouldn't Take NIFEdipine?
- Known hypersensitivity to nifedipine or any component of the formulation.
- Severe hypotension (low blood pressure).
- Aortic stenosis or unstable angina.
Advice From The Pharmacist
- Take NIFEdipine exactly as prescribed, and do not crush or chew extended-release formulations.
- Monitor blood pressure regularly to ensure effectiveness and adjust the dosage as necessary.
- Be cautious when engaging in activities that require alertness, as nifedipine may cause dizziness.
Side Effects of NIFEdipine
Common Side Effects
- Headache
- Dizziness
- Flushing
- Peripheral edema (swelling of the limbs)
- Fatigue
Uncommon/Severe Side Effects
- Severe hypotension
- Worsening angina
- Allergic reactions (rash, itching, swelling).
Risks and Warnings of NIFEdipine
- Hypotension: Monitor blood pressure closely, especially when starting treatment or adjusting doses.
- Heart Function: Use with caution in patients with heart failure or significant aortic stenosis.
Interactions with NIFEdipine
Common Drug Interactions
- Other Antihypertensives: Use caution when combined with other medications that lower blood pressure.
- Grapefruit Juice: May increase the levels of nifedipine; avoid excessive consumption.
Alternatives to NIFEdipine
- Other Calcium Channel Blockers: Such as amlodipine or diltiazem for managing hypertension and angina.
- ACE Inhibitors: As alternative antihypertensive options.
