NiHowdy > Drug Classes > NMDA Receptor Antagonists

Browse Medications by Drug Class: NMDA Receptor Antagonists

Written by Amar Lunagaria

Pharm.D • NiHowdy Founder

Reviewed by James Wong

Pharm.D • NiHowdy Founder

Published Jan 15, 2025

Fact checked

What are NMDA Receptor Antagonists?

NMDA receptor antagonists are a class of medications that inhibit the activity of N-methyl-D-aspartate (NMDA) receptors in the brain. These receptors play a critical role in regulating synaptic plasticity, learning, and memory but can also contribute to neurodegeneration and excitotoxicity when overactivated. By blocking these receptors, NMDA antagonists protect neurons and modulate brain activity, making them effective for treating conditions such as Alzheimer's disease, chronic pain, and certain psychiatric disorders. A unique feature of NMDA receptor antagonists is their dual role in neuroprotection and modulation of abnormal brain activity. NiHowdy ensures affordable access to these innovative therapies, empowering patients to manage complex neurological and psychiatric conditions.

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List of drugs in NMDA Receptor Antagonists

Drug Name	More Information	NiHowdy Prices & Bitcoin Rebate

Memantine HCl	Memantine HCl Information	Memantine HCl Pricing
Memantine HCl ER	Memantine HCl ER Information	Memantine HCl ER Pricing
Namenda	Namenda Information	Namenda Pricing
Namenda Titration Pak	Namenda Titration Pak Information	Namenda Titration Pak Pricing
Namenda XR	Namenda XR Information	Namenda XR Pricing
Namenda XR Titration Pack	Namenda XR Titration Pack Information	Namenda XR Titration Pack Pricing
Namzaric	Namzaric Information	Namzaric Pricing
Nuedexta	Nuedexta Information	Nuedexta Pricing
Spravato (56 MG Dose)	Spravato (56 MG Dose) Information	Spravato (56 MG Dose) Pricing
Spravato (84 MG Dose)	Spravato (84 MG Dose) Information	Spravato (84 MG Dose) Pricing

Brief history about NMDA Receptor Antagonists?

The therapeutic potential of NMDA receptor antagonists was recognized in the late 20th century with advances in understanding excitotoxicity and its role in neurological disorders. Early research focused on ketamine, an anesthetic with NMDA receptor-blocking properties, which later showed promise for depression and chronic pain management. Memantine, approved by the FDA in 2003 for Alzheimer's disease, brought NMDA antagonists to the forefront of neurodegenerative disease treatment. Today, these medications are being explored for a wide range of conditions, from chronic pain to psychiatric disorders. NiHowdy simplifies access to these groundbreaking treatments, ensuring affordability for patients seeking neurological care.

How do NMDA Receptor Antagonists work?

NMDA receptor antagonists work by selectively blocking NMDA receptors in the central nervous system. These receptors are activated by the neurotransmitter glutamate, which is essential for normal brain function but can cause neuronal damage when overproduced. By inhibiting NMDA receptor activity, these medications reduce excitotoxicity, a process where excessive glutamate leads to neuron damage or death. For example, memantine protects neurons in Alzheimer's disease by preventing glutamate overactivation, while ketamine modulates brain activity to relieve chronic pain and depressive symptoms. NiHowdy ensures patients can access these advanced therapies affordably and conveniently.

What are NMDA Receptor Antagonists used to treat?

Alzheimer's Disease

Memantine, an NMDA receptor antagonist, is used to treat moderate to severe Alzheimer's disease by reducing excitotoxicity and preserving neuronal function. It helps improve cognitive function, memory, and daily living activities, enhancing the quality of life for patients and caregivers.

Depression

Ketamine, an NMDA receptor antagonist, is used for treatment-resistant depression. By modulating glutamate levels, ketamine rapidly alleviates depressive symptoms, including suicidal ideation, making it a valuable option for patients who do not respond to traditional antidepressants.

Chronic Pain

NMDA receptor antagonists like ketamine are used to manage chronic pain conditions, including complex regional pain syndrome (CRPS) and neuropathic pain. These medications reduce central sensitization, a mechanism underlying chronic pain, offering relief when other treatments fail.

Epilepsy

NMDA receptor antagonists are being explored as potential treatments for epilepsy by reducing abnormal neuronal firing associated with seizures. Their neuroprotective properties may offer additional benefits for patients with refractory epilepsy.

Who should consider NMDA Receptor Antagonists medications?

Adults

Adults with conditions like Alzheimer's disease, treatment-resistant depression, or chronic pain may benefit significantly from NMDA receptor antagonists. These medications provide neuroprotection and symptom relief, offering hope for individuals with limited treatment options. Healthcare providers carefully tailor therapies to the patient's condition and overall health.

Children

NMDA receptor antagonists are not commonly used in pediatric populations but may be considered in specific cases, such as severe epilepsy or chronic pain. Dosing and monitoring are meticulously managed to ensure safety and efficacy for younger patients.

Seniors

Seniors with neurodegenerative diseases or chronic pain benefit from NMDA receptor antagonists like memantine, which are well-tolerated and provide cognitive and functional improvements. Healthcare providers monitor for potential side effects, such as confusion or dizziness, to optimize treatment in this population.

Are NMDA Receptor Antagonists safe?

NMDA receptor antagonists are generally safe when used under medical supervision. Common side effects include dizziness, headache, and nausea, which are usually mild and transient. Rare but serious risks include hallucinations, confusion, or increased blood pressure, particularly with higher doses or specific agents like ketamine. Regular follow-ups and careful monitoring ensure the safe and effective use of these medications.

Can I take NMDA Receptor Antagonists during pregnancy?

The safety of NMDA receptor antagonists during pregnancy depends on the specific medication and condition being treated. Pregnant individuals should consult their healthcare provider to weigh the benefits and risks and explore alternative treatments if necessary.

Are NMDA Receptor Antagonists safe to take while lactating?

The safety of NMDA receptor antagonists during breastfeeding is not well established. Patients should discuss potential risks and benefits with their healthcare provider to make informed decisions about treatment while lactating.

Are NMDA Receptor Antagonists controlled substances?

Certain NMDA receptor antagonists, like ketamine, are classified as controlled substances due to their potential for misuse and dependency. Others, like memantine, are not controlled substances but still require a prescription and medical supervision for safe use.

Side effects of NMDA Receptor Antagonists?

NMDA receptor antagonists are generally well-tolerated but may cause side effects depending on the specific medication and dosage. Common side effects include dizziness, fatigue, and mild gastrointestinal symptoms such as nausea or constipation. These effects are typically mild and improve with continued use or dose adjustments. Less common side effects include confusion, hallucinations, or headaches, which may occur in sensitive individuals or at higher doses. These symptoms require monitoring and may necessitate changes in the treatment plan. Rare but serious side effects include increased blood pressure, respiratory depression, or adverse psychiatric effects, particularly with medications like ketamine. Patients experiencing severe symptoms should seek immediate medical attention. Regular follow-ups with healthcare providers ensure these medications are used safely and effectively.

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Cost considerations and insurance coverage for NMDA Receptor Antagonists

The cost of NMDA receptor antagonists varies depending on the specific medication and indication. Generic options like memantine are affordable, while treatments like ketamine infusions can be more expensive. Most insurance plans cover FDA-approved uses, such as Alzheimer's disease or treatment-resistant depression. NiHowdy offers discounts, rebates, and Bitcoin rewards to ensure these therapies remain accessible and cost-effective.

How do I get rebates on NMDA Receptor Antagonists?

NiHowdy's Bitcoin rebate program for NMDA receptor antagonist prescriptions provides patients with a unique opportunity to save on healthcare costs while earning potential financial growth. This innovative approach makes managing neurological and psychiatric conditions both affordable and rewarding, improving access to life-changing treatments while building long-term value.

Therapeutic Classes linked to NMDA Receptor Antagonists

Antidementia Agents (Alzheimer's)

Antidepressants (Mood Disorders)

Medical Conditions treated by NMDA Receptor Antagonists

Alzheimer's Disease

Browse Medications by Drug Class: NMDA Receptor Antagonists

What are NMDA Receptor Antagonists?

Stop overpaying for prescriptions

List of drugs in NMDA Receptor Antagonists

Brief history about NMDA Receptor Antagonists?

How do NMDA Receptor Antagonists work?

What are NMDA Receptor Antagonists used to treat?

Alzheimer's Disease

Depression

Chronic Pain

Epilepsy

Who should consider NMDA Receptor Antagonists medications?

Adults

Children

Seniors

Are NMDA Receptor Antagonists safe?

Can I take NMDA Receptor Antagonists during pregnancy?

Are NMDA Receptor Antagonists safe to take while lactating?

Are NMDA Receptor Antagonists controlled substances?

Side effects of NMDA Receptor Antagonists?

Join for FREE and start saving now!

Cost considerations and insurance coverage for NMDA Receptor Antagonists

How do I get rebates on NMDA Receptor Antagonists?

Therapeutic Classes linked to NMDA Receptor Antagonists

Medical Conditions treated by NMDA Receptor Antagonists

Everyday Health Concerns related to NMDA Receptor Antagonists

Mental Health

Neurological

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