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Namenda XR
Namenda XR (generic name: memantine hydrochloride) is a medication used to treat moderate to severe Alzheimer’s disease. It is classified as an N-methyl-D-aspartate (NMDA) receptor antagonist and works by regulating glutamate, a neurotransmitter associated with learning and memory, thereby helping to improve cognitive function and slow the progression of symptoms.
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Frequently Asked Questions
How quickly does Namenda XR work?
Patients may begin to notice improvements in cognitive function and behavior within several weeks of starting treatment, but full benefits may take longer to assess.
Can I take Namenda XR with food?
Yes, Namenda XR can be taken with or without food.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using Namenda XR?
There are no specific dietary restrictions while using Namenda XR.
Is Namenda XR safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Namenda XR during these periods.
Comprehensive Drug Guide
How Does Namenda XR Work?
Memantine works by blocking NMDA receptors in the brain, which reduces the excitotoxic effects of excessive glutamate activity. By stabilizing glutamate levels, it helps protect neurons from damage and may slow the progression of cognitive decline associated with Alzheimer’s disease.
Common Dosages
- Extended-Release Capsules: 7 mg, 14 mg, 21 mg, and 28 mg.
Typical Dosing
- The usual starting dose for adults is 7 mg once daily, which may be increased weekly by 7 mg increments to a maximum recommended dose of 28 mg once daily based on the patient's tolerance and response.
Typical Dosing
FDA Approved Indications
- Alzheimer’s Disease: for the treatment of moderate to severe Alzheimer’s disease in adults.
Who Shouldn't Take Namenda XR?
- Known hypersensitivity to memantine or any component of the formulation.
- Severe renal impairment without careful monitoring.
Advice From The Pharmacist
- Take Namenda XR exactly as prescribed, and do not crush or chew the capsules; swallow them whole.
- Consistent daily dosing is important for maintaining therapeutic levels.
- Monitor for any changes in mood, behavior, or cognitive function, and report them to your healthcare provider.
Side Effects of Namenda XR
Common Side Effects
- Dizziness
- Headache
- Confusion
- Constipation
- Fatigue
Uncommon/Severe Side Effects
- Allergic reactions (rash, itching, swelling)
- Seizures (in patients with a history of seizure disorders).
Risks and Warnings of Namenda XR
- Cognitive Effects: Monitor for worsening symptoms of confusion or behavioral changes.
- Renal Function: Use with caution in patients with renal impairment; dosage adjustments may be necessary.
Interactions with Namenda XR
Common Drug Interactions
- Other NMDA Antagonists: Use caution when combined with other medications that may affect glutamate levels.
- Carbonic Anhydrase Inhibitors: Such as acetazolamide may increase the risk of adverse effects.
Alternatives to Namenda XR
- Cholinesterase Inhibitors: Such as donepezil or rivastigmine for managing Alzheimer’s disease symptoms.
- Other Cognitive Enhancers: Depending on the specific needs of the patient.
