NiHowdy > Drug Classes > Integrase Strand Transfer Inhibitors

Browse Medications by Drug Class: Integrase Strand Transfer Inhibitors

Written by Amar Lunagaria

Pharm.D • NiHowdy Founder

Reviewed by James Wong

Pharm.D • NiHowdy Founder

Published Jan 15, 2025

Fact checked

What are Integrase Strand Transfer Inhibitors?

HIV integrase strand transfer inhibitors (INSTIs) are antiretroviral medications that target the integrase enzyme, a critical component of the HIV life cycle. By blocking the strand transfer step of viral DNA integration into the host genome, these medications prevent the virus from establishing a permanent infection in CD4+ T cells. INSTIs are highly effective, fast-acting, and well-tolerated, making them a cornerstone of modern HIV treatment regimens. A unique characteristic of INSTIs is their potency in rapidly reducing viral loads while maintaining a favorable safety profile. NiHowdy ensures affordable access to these therapies, empowering patients to manage HIV effectively and improve long-term health outcomes.

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List of drugs in Integrase Strand Transfer Inhibitors

Drug Name	More Information	NiHowdy Prices & Bitcoin Rebate

Apretude	Apretude Information	Apretude Pricing
Biktarvy	Biktarvy Information	Biktarvy Pricing
Cabenuva	Cabenuva Information	Cabenuva Pricing
Dovato	Dovato Information	Dovato Pricing
Genvoya	Genvoya Information	Genvoya Pricing
Isentress	Isentress Information	Isentress Pricing
Isentress HD	Isentress HD Information	Isentress HD Pricing
Juluca	Juluca Information	Juluca Pricing
Stribild	Stribild Information	Stribild Pricing
Tivicay	Tivicay Information	Tivicay Pricing
Tivicay PD	Tivicay PD Information	Tivicay PD Pricing
Triumeq	Triumeq Information	Triumeq Pricing
Triumeq PD	Triumeq PD Information	Triumeq PD Pricing

Brief history about Integrase Strand Transfer Inhibitors?

The development of INSTIs marked a significant breakthrough in HIV treatment, with the first FDA-approved integrase inhibitor, raltegravir, introduced in 2007. This class of drugs quickly gained prominence due to their high efficacy and unique mechanism of action. Subsequent INSTIs, such as dolutegravir, bictegravir, and elvitegravir, offered improved potency, longer half-lives, and fewer drug interactions. Today, INSTIs are a preferred option for both treatment-naive and experienced patients. NiHowdy simplifies access to these life-changing medications, ensuring affordability for individuals managing HIV.

How do Integrase Strand Transfer Inhibitors work?

HIV integrase strand transfer inhibitors work by inhibiting the integrase enzyme, which the virus uses to insert its DNA into the host cell's genome?a critical step in the viral replication process. INSTIs bind to the integrase-DNA complex and block the strand transfer reaction, preventing the integration of viral DNA into the host's chromosomal DNA. This mechanism halts the production of new virus particles and significantly reduces the viral load. For example, dolutegravir is known for its rapid action and durability in suppressing HIV replication. NiHowdy ensures patients can access these advanced therapies affordably and conveniently.

What are Integrase Strand Transfer Inhibitors used to treat?

HIV

INSTIs are a cornerstone of first-line antiretroviral therapy (ART) regimens for newly diagnosed HIV patients. These medications, often combined with other antiretroviral agents, rapidly reduce viral loads, improve immune function, and achieve durable viral suppression. For individuals with treatment-resistant HIV, INSTIs provide a highly effective option due to their unique mechanism and high barrier to resistance. Medications like dolutegravir and bictegravir are particularly effective in overcoming resistant viral strains. INSTIs indirectly reduce the risk of HIV transmission by achieving and maintaining undetectable viral loads in treated individuals. This supports the principle of ?Undetectable = Untransmittable? (U=U), enhancing public health outcomes.

Who should consider Integrase Strand Transfer Inhibitors medications?

Adults

Adults with HIV benefit significantly from INSTIs as part of their ART regimen. These medications are effective for newly diagnosed individuals and those with treatment-resistant HIV. Healthcare providers customize treatment plans to meet individual health needs and goals.

Children

INSTIs are approved for pediatric use and are particularly beneficial for children and adolescents with HIV. These medications offer safe and effective viral suppression with age-appropriate formulations and dosing, ensuring long-term health improvements.

Seniors

Seniors with HIV, including those with comorbidities or age-related immune changes, benefit from INSTIs due to their favorable safety profile and efficacy. Regular monitoring ensures that therapy is optimized for this population.

Are Integrase Strand Transfer Inhibitors safe?

INSTIs are generally safe and well-tolerated when used as prescribed. Common side effects include headache, nausea, fatigue, and diarrhea, which are typically mild and transient. Rare but serious risks include allergic reactions, liver enzyme elevations, and, in some cases, weight gain. Regular follow-ups with a healthcare provider ensure that side effects are managed effectively, and therapy remains safe and effective.

Can I take Integrase Strand Transfer Inhibitors during pregnancy?

INSTIs, such as dolutegravir, are considered safe during pregnancy and are often included in ART regimens to prevent mother-to-child transmission of HIV. Pregnant individuals should consult their healthcare provider to confirm the best treatment plan.

Are Integrase Strand Transfer Inhibitors safe to take while lactating?

Breastfeeding is not recommended for individuals with HIV due to the risk of viral transmission through breast milk, regardless of antiretroviral therapy. Patients should discuss feeding options with their healthcare provider to ensure the safety and well-being of their child.

Are Integrase Strand Transfer Inhibitors controlled substances?

HIV integrase strand transfer inhibitors are not classified as controlled substances. However, they require a prescription and medical supervision to ensure appropriate use, particularly as part of combination therapy for managing HIV.

Side effects of Integrase Strand Transfer Inhibitors?

INSTIs are highly effective and generally well-tolerated, but they may cause side effects. Common side effects include headache, nausea, fatigue, and mild gastrointestinal discomfort, which usually resolve as the body adjusts to the medication. Less common side effects include sleep disturbances, weight gain, or mild liver enzyme elevations, particularly in individuals with pre-existing liver conditions. Rarely, INSTIs may cause severe allergic reactions or hypersensitivity, necessitating immediate medical attention. To minimize risks, healthcare providers tailor treatment regimens to individual needs and closely monitor patients for side effects. Regular follow-ups and laboratory tests ensure the safe and effective use of INSTIs, optimizing long-term outcomes for patients living with HIV.

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Cost considerations and insurance coverage for Integrase Strand Transfer Inhibitors

The cost of INSTIs varies depending on the specific medication and formulation. These medications are often included in combination regimens, which may increase overall costs. However, most insurance plans cover INSTIs as part of standard HIV treatment. Pharmaceutical assistance programs and support services help reduce out-of-pocket expenses. NiHowdy offers discounts, rebates, and Bitcoin rewards to ensure these life-saving treatments remain accessible and cost-effective.

How do I get rebates on Integrase Strand Transfer Inhibitors?

NiHowdy's Bitcoin rebate program for HIV integrase strand transfer inhibitor prescriptions provides patients with a unique opportunity to save on healthcare costs while earning potential financial growth. This innovative approach makes managing HIV both affordable and rewarding, improving access to life-changing treatments while building long-term value.