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Genvoya
Genvoya is a combination antiretroviral medication used for the treatment of HIV-1 infection in adults and pediatric patients aged 12 years and older. It contains three active ingredients: elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide. Genvoya is effective in reducing the viral load in HIV-infected individuals and is used as part of a comprehensive treatment regimen.
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Frequently Asked Questions
How long does it take for Genvoya to start working?
Patients may start to see a decrease in viral load within weeks of starting treatment, but individual responses may vary.
Can I take Genvoya with other medications?
Yes, but always inform your healthcare provider about all medications you are taking to avoid potential interactions.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up.
Are there any specific storage instructions for Genvoya?
Store at room temperature, away from light and moisture. Keep out of reach of children.
Is Genvoya safe for long-term use?
Genvoya is generally safe for long-term use, but regular monitoring of kidney and liver function is important as part of the treatment plan.
Comprehensive Drug Guide
How Does Genvoya Work?
Genvoya works by combining the actions of its components. Elvitegravir inhibits the integrase enzyme, preventing the integration of viral DNA into the host cell's DNA. Emtricitabine and tenofovir alafenamide are NRTIs that interfere with viral RNA synthesis, effectively halting viral replication. Cobicistat is included to enhance the effectiveness of elvitegravir by inhibiting its metabolism, allowing for increased levels of the integrase inhibitor.
Common Dosages
Genvoya is available in the following form:
- Oral tablets: Typically available in a strength of 150 mg/150 mg/10 mg/300 mg (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide).
Typical Dosing
The typical dosing for Genvoya is:
- For HIV-1 Infection: One tablet taken orally once daily with food.
Typical Dosing
FDA Approved Indications
Treatment of HIV-1 infection in adults and pediatric patients aged 12 years and older who weigh at least 35 kg.
Who Shouldn't Take Genvoya?
- Hypersensitivity: Known hypersensitivity to any of the components of Genvoya.
- Severe Liver Impairment: Caution is advised in patients with moderate to severe liver disease.
Advice From The Pharmacist
- How to Take: Take Genvoya with food to enhance absorption and effectiveness.
- Regular Monitoring: Regularly monitor renal function and viral load as part of the treatment plan.
- Adherence: Emphasize the importance of adherence to the prescribed regimen to avoid the development of resistance.
Side Effects of Genvoya
Common Side Effects
- Nausea
- Diarrhea
- Fatigue
- Headache
Uncommon/Severe Side Effects
- Liver problems: Signs include jaundice, dark urine, and persistent nausea.
- Renal impairment: Monitor for changes in kidney function.
Risks and Warnings of Genvoya
- Risk of Hepatotoxicity: Monitor liver function regularly, particularly in patients with a history of liver disease.
- Bone Density Changes: Tenofovir alafenamide may affect bone mineral density; monitor patients at risk.
- Drug Interactions: Genvoya may interact with other medications; inform your healthcare provider about all medications being taken.
Interactions with Genvoya
Common Drug Interactions
- Drug Interactions: Caution is advised when used with other medications that affect renal function or those that are metabolized by CYP enzymes. Always consult your healthcare provider about potential interactions.
- Food Interactions: Taking Genvoya with food enhances absorption and effectiveness.
Alternatives to Genvoya
Other Antiretroviral Regimens: Such as Biktarvy or Triumeq, which may contain different combinations of integrase inhibitors and NRTIs.
