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Isentress HD

Isentress HD (raltegravir) is an antiretroviral medication used in the treatment of HIV-1 infection. It is part of the integrase strand transfer inhibitor (INSTI) class of drugs, which work by blocking the integrase enzyme, preventing the integration of viral DNA into the host cell's DNA. This helps to reduce the viral load in the body.



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Frequently Asked Questions

How long does it take for Isentress HD to start working?
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Isentress HD begins to reduce viral load shortly after starting treatment, but it is important to continue taking it as prescribed for optimal viral suppression.

Can I take Isentress HD with other medications?
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Always consult your healthcare provider before combining Isentress HD with other medications, especially antacids or other antiretrovirals.

What should I do if I miss a dose of Isentress HD?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Is it safe to use Isentress HD during pregnancy?
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Isentress HD should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.

Can Isentress HD cause weight gain?
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Weight gain is not a commonly reported side effect of Isentress HD, but individual responses can vary. Any significant changes in weight should be discussed with a healthcare provider.

Comprehensive Drug Guide

How Does Isentress HD Work?

Raltegravir inhibits the integrase enzyme, which is crucial for the HIV replication process. By blocking this enzyme, Isentress HD prevents the integration of viral DNA into the host cell's genome, thereby stopping the virus from multiplying and spreading within the body.



Common Dosages

  • Tablets: Each tablet contains 600 mg of raltegravir.

Typical Dosing

  • The usual dosage for adults is 1 tablet (600 mg) taken orally once daily, with or without food. Dosing may vary based on the specific treatment regimen and the presence of other medications.


Typical Dosing

FDA Approved Indications

  • Treatment of HIV-1 infection in adults and pediatric patients (age 12 years and older) as part of a complete HIV treatment regimen.


Who Shouldn't Take Isentress HD?

  • Known hypersensitivity to raltegravir or any components of the formulation.


Advice From The Pharmacist

  • Patients should be advised to take Isentress HD at the same time each day to maintain consistent drug levels in the body.
  • Inform patients about the importance of adhering to their HIV treatment regimen, as missed doses can lead to viral resistance.
  • Encourage patients to discuss any other medications they are taking to prevent potential drug interactions.


Side Effects of Isentress HD

Common Side Effects

  • Headache
  • Nausea
  • Diarrhea
  • Fatigue
  • Insomnia


Uncommon/Severe Side Effects

  • Severe allergic reactions (anaphylaxis)
  • Liver problems
  • Muscle pain or weakness (myopathy)


Risks and Warnings of Isentress HD

  • Drug Interactions: Raltegravir can interact with other medications, so it's important for patients to inform their healthcare provider about all medications and supplements they are taking.
  • Monitoring: Regular follow-up appointments are necessary to monitor liver function and overall treatment efficacy.


Interactions with Isentress HD

Common Drug Interactions

  • Antacids: Taking antacids containing aluminum or magnesium within 2 hours of Isentress HD may reduce its effectiveness.
  • Other Antiretrovirals: Caution is advised when used with other HIV medications, as interactions may affect efficacy.


Alternatives to Isentress HD

  • Other Integrase Inhibitors: Such as dolutegravir or bictegravir for treating HIV.
  • Different Classes of Antiretrovirals: Like non-nucleoside reverse transcriptase inhibitors (NNRTIs) or protease inhibitors (PIs).