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Tivicay PD
Tivicay PD (generic name: dolutegravir) is an antiretroviral medication used to treat HIV-1 infection in pediatric patients. It belongs to the class of drugs known as integrase strand transfer inhibitors (INSTIs), which block the enzyme integrase that the HIV virus needs to replicate in the body. By inhibiting this enzyme, Tivicay PD helps reduce the amount of HIV in the blood, allowing the immune system to function better and decreasing the risk of HIV-related complications.
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Frequently Asked Questions
How long does it take for Tivicay PD to start working?
Tivicay PD begins working within several days of starting therapy. However, it may take several weeks or months to see a significant reduction in viral load.
Can Tivicay PD cure HIV?
No, Tivicay PD does not cure HIV. It helps control the virus and allows the immune system to function better, but long-term treatment is necessary to keep the virus in check.
What should I do if I miss a dose of Tivicay PD?
If you miss a dose, take it as soon as you remember. If it is close to the time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Can Tivicay PD be taken with food?
Yes, Tivicay PD can be taken with or without food. However, it should not be taken with antacids, as these can interfere with absorption.
Is Tivicay PD safe for long-term use?
Yes, Tivicay PD is generally safe for long-term use when taken as prescribed. Regular monitoring of viral load, liver function, and kidney function is essential to ensure the medication continues to be effective and safe.
Comprehensive Drug Guide
How Does Tivicay PD Work?
Tivicay PD works by inhibiting the HIV integrase enzyme, which is necessary for the virus to integrate its genetic material into the host cell’s DNA. By blocking this process, Tivicay PD prevents the replication of the virus, reducing the viral load in the bloodstream and helping to control the HIV infection.
Common Dosages
- 5 mg dispersible tablets
Typical Dosing
- For pediatric patients: The dosage is based on the child’s weight. The typical dosing schedule for children weighing at least 3 kg is as follows:
- 3 to <6 kg: 5 mg once daily
- 6 to <10 kg: 10 mg once daily
- 10 to <14 kg: 15 mg once daily
- 14 to <20 kg: 20 mg once daily
- 20 to <25 kg: 25 mg once daily
- 25 to <30 kg: 30 mg once daily
- ≥30 kg: 35 mg once daily
Typical Dosing
FDA Approved Indications
- Treatment of HIV-1 infection in pediatric patients aged 4 weeks and older weighing at least 3 kg, in combination with other antiretroviral agents.
Who Shouldn't Take Tivicay PD?
- Known hypersensitivity to dolutegravir or any of its components
- Concurrent use of dofetilide, a medication used to treat heart rhythm disorders
Advice From The Pharmacist
- Disperse the tablet in water as directed before giving it to the child. Do not chew or swallow the tablet whole.
- Ensure the full dose is given by having the child drink the entire solution. If any residue remains in the cup, add a small amount of water to ensure the full dose is taken.
- Regularly monitor viral load and immune function in your child to assess the effectiveness of the treatment.
- Store the medication in a cool, dry place, away from moisture and light.
Side Effects of Tivicay PD
Common Side Effects
- Diarrhea
- Nausea
- Headache
- Fatigue
- Trouble sleeping (insomnia)
Uncommon/Severe Side Effects
- Allergic reactions (rash, itching, swelling, difficulty breathing)
- Liver damage (yellowing of the skin or eyes, dark urine, severe fatigue)
- Depression or mood changes
- Hypersensitivity reactions, which may involve fever, rash, and organ dysfunction
Risks and Warnings of Tivicay PD
- Liver Toxicity: Tivicay PD may cause liver damage, especially in individuals with pre-existing liver conditions or those co-infected with hepatitis B or C. Monitor liver function tests regularly.
- Hypersensitivity Reactions: Severe allergic reactions, including rashes, fever, and organ problems, can occur. Discontinue use and seek immediate medical attention if such symptoms develop.
- Drug Resistance: Missing doses or not adhering to the prescribed regimen may lead to the development of drug-resistant HIV strains. Ensure the medication is taken as prescribed.
Interactions with Tivicay PD
Common Drug Interactions
- Dofetilide: Tivicay PD is contraindicated with this medication due to the risk of serious or life-threatening side effects.
- Antacids: Medications containing magnesium, aluminum, or calcium can reduce the absorption of Tivicay PD. Take them at least 2 hours before or 6 hours after taking Tivicay PD.
- Rifampin: Rifampin may reduce the effectiveness of Tivicay PD, and dose adjustments may be required.
Alternatives to Tivicay PD
- Raltegravir (Isentress): Another integrase inhibitor used to treat HIV in pediatric patients.
- Abacavir/Lamivudine (Epzicom): A combination antiretroviral therapy used for HIV in children and adults.
- Atazanavir (Reyataz): A protease inhibitor used as part of combination therapy for HIV.
