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Epzicom
Epzicom is a combination of two antiretroviral medications, abacavir and lamivudine, used to treat HIV infection. It belongs to the class of nucleoside reverse transcriptase inhibitors (NRTIs), which help decrease the amount of HIV in the body and improve immune function when used with other antiretroviral drugs. Epzicom is used as part of highly active antiretroviral therapy (HAART) to manage HIV infection.
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Frequently Asked Questions
Can Epzicom cure HIV?
No, Epzicom does not cure HIV, but it helps control the infection and lowers the viral load when used with other antiretroviral drugs.
What should I do if I miss a dose of Epzicom?
If you miss a dose of Epzicom, take it as soon as you remember. If it is close to your next dose, skip the missed dose and resume your regular schedule. Do not double up doses.
How does the HLA-B5701 test affect Epzicom treatment?
The HLA-B*5701 test is used to identify patients at risk for a severe allergic reaction to abacavir, one of the components of Epzicom. Patients who test positive should not take this medication.
Can Epzicom cause liver problems?
Yes, Epzicom can cause liver damage in some patients. Regular liver function tests may be required to monitor for potential problems.
Is Epzicom safe during pregnancy?
Yes, Epzicom can be used during pregnancy, but consult your doctor for specific recommendations and to discuss risks and benefits.
Comprehensive Drug Guide
How Does Epzicom Work?
Epzicom works by inhibiting reverse transcriptase, an enzyme that HIV uses to replicate and multiply. By blocking this enzyme, abacavir and lamivudine prevent HIV from making copies of itself, helping to reduce viral load and maintain immune function.
Common Dosages
- Tablet: containing 600 mg abacavir and 300 mg lamivudine
Typical Dosing
- The typical dose of Epzicom is one tablet once daily, taken with or without food, in combination with other antiretroviral medications as part of an HIV treatment regimen.
Typical Dosing
FDA Approved Indications
- Treatment of HIV infection in combination with other antiretrovirals
Who Shouldn't Take Epzicom?
- Known hypersensitivity to abacavir, lamivudine, or any of the tablet's components.
- Presence of the HLA-B*5701 allele (patients with this gene variant are at increased risk of severe allergic reactions to abacavir).
Advice From The Pharmacist
- Before starting Epzicom, patients should be tested for the HLA-B*5701 allele to avoid serious allergic reactions.
- Take Epzicom daily as prescribed. Missing doses may lead to drug resistance.
- Store the medication at room temperature and keep it in a dry place.
Side Effects of Epzicom
Common Side Effects
- Headache
- Nausea
- Fatigue
- Diarrhea
Uncommon/Severe Side Effects
- Hypersensitivity reactions (fever, rash, nausea, and difficulty breathing)
- Lactic acidosis
- Hepatotoxicity (liver damage)
Risks and Warnings of Epzicom
- Hypersensitivity Reaction: Epzicom can cause serious and potentially life-threatening allergic reactions. If symptoms of hypersensitivity occur, the medication must be stopped immediately, and it should never be restarted.
- Lactic Acidosis: Epzicom may cause a rare but serious condition called lactic acidosis (buildup of lactic acid in the blood). Symptoms include weakness, fatigue, and rapid breathing.
Interactions with Epzicom
Common Drug Interactions
- Methadone: Epzicom may reduce the effectiveness of methadone, so dosage adjustments may be necessary.
- Alcohol: Abacavir can increase the risk of liver toxicity when combined with alcohol. Limit alcohol intake while using Epzicom.
Alternatives to Epzicom
- Truvada (tenofovir/emtricitabine)
- Descovy (tenofovir alafenamide/emtricitabine)
- Triumeq (dolutegravir/abacavir/lamivudine)
