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Reyataz
Reyataz, the brand name for atazanavir, is an antiretroviral medication used in the treatment of HIV-1 infection. It is part of the protease inhibitor (PI) class of drugs and is typically prescribed in combination with other antiretroviral medications to help control HIV. Reyataz works by inhibiting the activity of the HIV protease enzyme, which is crucial for the virus to multiply. Although not a cure for HIV, Reyataz helps reduce the viral load in the body, maintain immune function, and lower the risk of developing AIDS or other HIV-related complications.
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Frequently Asked Questions
What should I do if I miss a dose of Reyataz?
If you miss a dose of Reyataz, take it as soon as you remember, but skip it if it’s almost time for your next dose. Do not double up on doses to make up for a missed one.
Can I take Reyataz with food?
Yes, Reyataz should be taken with food to improve absorption and ensure its effectiveness.
What should I avoid while taking Reyataz?
Avoid taking antacids or proton pump inhibitors close to your dose, as they can interfere with how well Reyataz is absorbed. Also, avoid St. John’s Wort as it can reduce the effectiveness of Reyataz.
How long does Reyataz take to work?
Reyataz works to lower the viral load over time. It may take several weeks of consistent use in combination with other antiretrovirals to see significant reductions in viral levels, and regular blood tests will be done to monitor your progress.
Does Reyataz cure HIV?
No, Reyataz does not cure HIV, but it helps manage the infection by reducing the viral load in the body, improving immune function, and reducing the risk of HIV-related complications.
Comprehensive Drug Guide
How Does Reyataz Work?
Reyataz works by inhibiting the HIV protease enzyme, which is essential for the virus to replicate and produce new viral particles. By blocking this enzyme, Reyataz prevents the virus from maturing, thereby reducing the viral load in the body. This allows the immune system to function better and helps slow the progression of HIV infection, reducing the risk of HIV-related complications and improving the patient's quality of life.
Common Dosages
- Capsules: 150 mg, 200 mg, and 300 mg
- Oral powder for pediatric patients: 50 mg/packet
Typical Dosing
- For adults: The standard adult dose is 300 mg once daily, taken with 100 mg of ritonavir (Norvir) as a boosting agent. This should be taken with food to enhance absorption.
- For pediatric patients: The dose depends on body weight, and Reyataz is typically given in combination with ritonavir.
- Dose adjustments may be necessary for patients with liver impairment or those taking certain other medications.
Typical Dosing
For adults:
- The typical dose of Reyataz for adults is 300 mg once daily, taken with ritonavir (a boosting agent) and other antiretroviral medications.
- If ritonavir is not used, the dosing regimen may differ based on other factors, including other medications taken.
For pediatric patients (3 months and older, weighing at least 10 kg):
- The dose is determined by weight and is taken once daily with food.
Always follow the dosing instructions provided by your healthcare provider.
Typical Dosing
FDA Approved Indications
- Treatment of HIV-1 infection in combination with other antiretroviral agents in adults and pediatric patients 3 months of age and older who weigh at least 10 kg.
Who Shouldn't Take Reyataz?
Reyataz should not be used in the following cases:
- Known hypersensitivity to atazanavir or any component of the formulation.
- Severe liver dysfunction or liver disease.
- Co-administration with certain medications, such as rifampin, proton pump inhibitors (e.g., omeprazole), and St. John’s wort, as these can reduce the effectiveness of Reyataz or increase the risk of side effects.
Always inform your healthcare provider of any other medications or medical conditions before starting Reyataz.
Advice From The Pharmacist
- Reyataz should be taken once daily with food, as food helps increase the absorption of the medication.
- Make sure to follow the instructions for any other medications, such as ritonavir, that are prescribed alongside Reyataz.
- Stay consistent with your medication schedule and avoid missing doses, as adherence is crucial in preventing the virus from becoming resistant to treatment.
- Regular blood tests will be required to monitor your viral load, liver function, and overall health while taking Reyataz.
- Avoid taking antacids or medications that reduce stomach acid close to your dose, as they can interfere with the absorption of Reyataz.
Side Effects of Reyataz
Common Side Effects
- Nausea
- Stomach pain or upset
- Diarrhea
- Headache
- Jaundice (yellowing of the skin or eyes), which can occur due to an increase in bilirubin levels
- Fatigue
Uncommon/Severe Side Effects
- Heart rhythm problems (such as prolonged QT interval), which can cause an irregular heartbeat.
- Liver problems, indicated by symptoms such as dark urine, severe fatigue, or jaundice.
- Kidney stones or other kidney issues, which may present as pain in the side or back and blood in the urine.
Risks and Warnings of Reyataz
- Reyataz can cause an increase in bilirubin levels, which may lead to jaundice (yellowing of the skin or eyes). While this is usually harmless, it can be concerning for some patients.
- Reyataz should be used with caution in patients with pre-existing liver disease, including hepatitis B or C, as it can worsen liver function.
- Patients should have their liver enzymes and kidney function monitored regularly.
- Reyataz may also cause heart rhythm problems in some patients, so your healthcare provider may monitor your heart function if you are at risk.
Interactions with Reyataz
Common Drug Interactions
- Rifampin (a tuberculosis medication), which can reduce the effectiveness of Reyataz.
- Proton pump inhibitors (such as omeprazole), which can decrease the absorption of Reyataz.
- Antacids or H2 receptor antagonists (such as famotidine), which should be spaced out from Reyataz to avoid reduced absorption.
- St. John’s Wort, which can lower the levels of Reyataz in the body and reduce its effectiveness.
Alternatives to Reyataz
- Darunavir (Prezista)
- Lopinavir/ritonavir (Kaletra)
- Raltegravir (Isentress) – an integrase inhibitor
- Dolutegravir (Tivicay) – an integrase inhibitor
