NiHowdy > Drug Classes > Dipeptidyl Peptidase 4 Inhibitors

Browse Medications by Drug Class: Dipeptidyl Peptidase 4 Inhibitors

Written by Amar Lunagaria

Pharm.D • NiHowdy Founder

Reviewed by James Wong

Pharm.D • NiHowdy Founder

Published Jan 15, 2025

Fact checked

What are Dipeptidyl Peptidase 4 Inhibitors?

Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of oral medications used to manage type 2 diabetes. They work by blocking the enzyme DPP-4, which breaks down incretin hormones like GLP-1 and GIP. These hormones help regulate blood sugar levels by increasing insulin release and reducing glucagon production in response to meals. By enhancing the activity of incretins, DPP-4 inhibitors improve glycemic control without causing significant weight gain or increasing the risk of hypoglycemia. A unique characteristic of DPP-4 inhibitors is their ability to provide blood sugar control while being generally well-tolerated. NiHowdy ensures affordable access to these essential medications, helping patients achieve their diabetes management goals.

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List of drugs in Dipeptidyl Peptidase 4 Inhibitors

Drug Name	More Information	NiHowdy Prices & Bitcoin Rebate

Alogliptin Benzoate	Alogliptin Benzoate Information	Alogliptin Benzoate Pricing
Alogliptin-metFORMIN HCl	Alogliptin-metFORMIN HCl Information	Alogliptin-metFORMIN HCl Pricing
Alogliptin-Pioglitazone	Alogliptin-Pioglitazone Information	Alogliptin-Pioglitazone Pricing
Janumet	Janumet Information	Janumet Pricing
Janumet XR	Janumet XR Information	Janumet XR Pricing
Januvia	Januvia Information	Januvia Pricing
Jentadueto	Jentadueto Information	Jentadueto Pricing
Jentadueto XR	Jentadueto XR Information	Jentadueto XR Pricing
Kombiglyze XR	Kombiglyze XR Information	Kombiglyze XR Pricing
Nesina	Nesina Information	Nesina Pricing
Onglyza	Onglyza Information	Onglyza Pricing
Oseni	Oseni Information	Oseni Pricing
Qtern	Qtern Information	Qtern Pricing
Tradjenta	Tradjenta Information	Tradjenta Pricing

Brief history about Dipeptidyl Peptidase 4 Inhibitors?

DPP-4 inhibitors were introduced in the mid-2000s as a novel treatment option for type 2 diabetes. Sitagliptin, the first approved drug in this class, provided a new mechanism of action that complemented existing therapies like metformin and sulfonylureas. Over time, additional DPP-4 inhibitors, including saxagliptin, linagliptin, and alogliptin, were developed, offering flexibility in treatment options. These medications have since become widely used due to their effectiveness, low risk of hypoglycemia, and favorable side effect profile. NiHowdy simplifies access to these innovative therapies, ensuring affordability for patients with type 2 diabetes.

How do Dipeptidyl Peptidase 4 Inhibitors work?

DPP-4 inhibitors work by blocking the activity of the enzyme dipeptidyl peptidase-4 (DPP-4), which degrades incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones play a crucial role in glucose homeostasis by enhancing insulin secretion from the pancreas and suppressing glucagon release. By prolonging the action of incretins, DPP-4 inhibitors help reduce postprandial (after-meal) blood sugar spikes and improve overall glycemic control. For example, sitagliptin effectively lowers HbA1c levels without significant weight gain, making it a valuable option for patients seeking balanced diabetes management. NiHowdy ensures patients can access these essential therapies affordably and conveniently.

What are Dipeptidyl Peptidase 4 Inhibitors used to treat?

Type 2 Diabetes

DPP-4 inhibitors are primarily used to manage type 2 diabetes by improving glycemic control. They enhance the body's natural ability to regulate blood sugar levels after meals, reducing postprandial glucose spikes and lowering HbA1c levels. These medications are often prescribed in combination with other diabetes treatments, such as metformin, to achieve optimal blood sugar control without increasing the risk of hypoglycemia.

Patients with Cardiovascular Risk Factors

Some DPP-4 inhibitors, such as sitagliptin and alogliptin, have been studied for their cardiovascular safety in patients with type 2 diabetes. While not specifically cardioprotective, these medications provide effective blood sugar management without adversely affecting heart health, making them suitable for patients with cardiovascular risk factors.

Who should consider Dipeptidyl Peptidase 4 Inhibitors medications?

Adults

Adults with type 2 diabetes who struggle with postprandial glucose control or cannot tolerate other diabetes medications may benefit from DPP-4 inhibitors. These medications are particularly useful for patients seeking effective glycemic management without significant weight gain or an increased risk of low blood sugar. DPP-4 inhibitors are often prescribed as part of a tailored diabetes treatment plan.

Children

DPP-4 inhibitors are not commonly used in pediatric populations, as type 2 diabetes is less prevalent in children and these medications are not approved for pediatric use. However, ongoing research may expand their application in the future for specific cases.

Seniors

Seniors with type 2 diabetes often benefit from DPP-4 inhibitors due to their safety profile and low risk of hypoglycemia. These medications are particularly valuable for older adults with comorbidities or those who require a less aggressive approach to diabetes management. Regular monitoring ensures optimal dosing and effectiveness.

Are Dipeptidyl Peptidase 4 Inhibitors safe?

DPP-4 inhibitors are generally safe and well-tolerated. Common side effects include upper respiratory infections, headache, and mild gastrointestinal discomfort. Rare but serious side effects include pancreatitis and joint pain, which should be reported to a healthcare provider immediately. Patients with pre-existing conditions, such as kidney impairment, may require dose adjustments or alternative treatments. Regular monitoring and follow-ups ensure the safe use of these medications.

Can I take Dipeptidyl Peptidase 4 Inhibitors during pregnancy?

The safety of DPP-4 inhibitors during pregnancy has not been well established, and they are generally not recommended for use in pregnant individuals. Patients planning a pregnancy or who are pregnant should consult their healthcare provider for alternative diabetes management strategies.

Are Dipeptidyl Peptidase 4 Inhibitors safe to take while lactating?

There is limited data on the safety of DPP-4 inhibitors during lactation. These medications are typically avoided unless deemed necessary by a healthcare provider. Patients should discuss potential risks and benefits to determine the safest treatment options.

Are Dipeptidyl Peptidase 4 Inhibitors controlled substances?

DPP-4 inhibitors are not classified as controlled substances. They are prescription medications used specifically to manage type 2 diabetes and require regular monitoring by a healthcare provider.

Side effects of Dipeptidyl Peptidase 4 Inhibitors?

DPP-4 inhibitors are generally well-tolerated, but like all medications, they can cause side effects. Common side effects include mild gastrointestinal discomfort, such as nausea or diarrhea, as well as upper respiratory tract symptoms like sore throat or nasal congestion. Some patients may experience headache or dizziness, particularly when starting treatment. Less common side effects include joint pain and skin reactions, such as rash or itching. Rare but serious risks include pancreatitis, a potentially life-threatening condition characterized by severe abdominal pain, nausea, and vomiting. Patients with a history of pancreatitis should avoid DPP-4 inhibitors or use them under close medical supervision. Regular monitoring and communication with a healthcare provider ensure the safe and effective use of DPP-4 inhibitors. Adjustments to dosing or switching to alternative medications may be necessary for patients experiencing persistent or severe side effects.

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Cost considerations and insurance coverage for Dipeptidyl Peptidase 4 Inhibitors

The cost of DPP-4 inhibitors varies by brand and formulation, with generic options generally more affordable. Many insurance plans cover these medications for type 2 diabetes, reducing out-of-pocket expenses. NiHowdy offers discounts, rebates, and Bitcoin rewards to ensure these essential treatments remain accessible and cost-effective for patients.

How do I get rebates on Dipeptidyl Peptidase 4 Inhibitors?

NiHowdy's Bitcoin rebate program for DPP-4 inhibitor prescriptions provides patients with a unique opportunity to save on healthcare costs while earning potential financial growth. This innovative approach makes managing type 2 diabetes both affordable and rewarding, improving access to life-enhancing treatments while building long-term value.

Therapeutic Classes linked to Dipeptidyl Peptidase 4 Inhibitors

Antidiabetics (Diabetes Management)

Everyday Health Concerns related to Dipeptidyl Peptidase 4 Inhibitors

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