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Oseni
Oseni (alogliptin and pioglitazone) is a combination medication used to improve blood sugar control in adults with type 2 diabetes mellitus. It combines two active ingredients: alogliptin, a DPP-4 inhibitor, and pioglitazone, a thiazolidinedione. This combination works by enhancing insulin sensitivity and increasing the levels of incretin hormones, which help regulate glucose levels in the blood.
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Frequently Asked Questions
How quickly will I see results with Oseni?
Many patients may see improvements in blood sugar levels within a few weeks, but optimal results can take longer and depend on diet and exercise adherence.
Can I take Oseni if I have heart problems?
You should discuss your medical history with your healthcare provider, as pioglitazone can exacerbate heart failure symptoms.
What should I do if I miss a dose?
Take the missed dose as soon as you remember, unless it’s close to the time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not double up.
Is weight gain common with Oseni?
Yes, weight gain can occur with pioglitazone; it’s important to monitor your weight and discuss any concerns with your healthcare provider.
Are there any dietary restrictions while taking Oseni?
There are no specific dietary restrictions, but maintaining a balanced diet and following your diabetes management plan is essential for optimal results.
Comprehensive Drug Guide
How Does Oseni Work?
- Alogliptin: Inhibits the DPP-4 enzyme, which breaks down incretin hormones. By increasing the levels of these hormones, alogliptin helps stimulate insulin secretion and decrease glucagon levels, leading to lower blood glucose levels.
- Pioglitazone: Enhances insulin sensitivity in muscle and fat tissues and reduces glucose production in the liver. This helps improve the body’s response to insulin and aids in better glycemic control.
Common Dosages
- Tablets: 15 mg/30 mg, 15 mg/45 mg (alogliptin/pioglitazone).
Typical Dosing
- Adults: The recommended starting dose is 15 mg of alogliptin and either 30 mg or 45 mg of pioglitazone taken once daily, with or without food. The dosage may be adjusted based on blood sugar levels and tolerability.
Typical Dosing
FDA Approved Indications
- Improving glycemic control in adults with type 2 diabetes mellitus, used in conjunction with diet and exercise.
Who Shouldn't Take Oseni?
- Known hypersensitivity to alogliptin, pioglitazone, or any components of the formulation
- Active bladder cancer
- Severe heart failure (due to pioglitazone)
- Uncontrolled diabetes or diabetic ketoacidosis
Advice From The Pharmacist
- Take Oseni as prescribed, at the same time each day, and do not exceed the recommended dose.
- Monitor blood glucose levels regularly to assess the effectiveness of the medication.
- Report any signs of heart failure (such as swelling, rapid weight gain, or shortness of breath) to your healthcare provider immediately.
- Discuss any other medications or supplements you are taking to avoid potential interactions.
Side Effects of Oseni
Common Side Effects
- Edema (swelling)
- Weight gain
- Nasopharyngitis (common cold symptoms)
- Headache
Uncommon/Severe Side Effects
- Heart failure exacerbation
- Bladder cancer
- Hepatic effects (liver dysfunction)
Risks and Warnings of Oseni
- Heart Failure Risk: Pioglitazone may increase the risk of heart failure; use with caution in patients with a history of heart problems.
- Bladder Cancer Risk: There is an increased risk of bladder cancer with pioglitazone; discuss your risk factors with your healthcare provider.
- Liver Function: Monitor liver enzymes periodically, as pioglitazone can cause liver dysfunction.
Interactions with Oseni
Common Drug Interactions
- Insulin: Increased risk of hypoglycemia when used with insulin or insulin secretagogues (sulfonylureas).
- CYP3A4 Inhibitors: Drugs that inhibit the CYP3A4 enzyme may increase alogliptin levels; consult your healthcare provider about potential interactions.
- Other Diabetes Medications: Be cautious when combining with other antidiabetic agents, as this may increase the risk of low blood sugar.
Alternatives to Oseni
- Other DPP-4 Inhibitors: Such as sitagliptin or linagliptin for similar glycemic control.
- Other Thiazolidinediones: Such as rosiglitazone for improving insulin sensitivity.
- Metformin: Often used as a first-line treatment for type 2 diabetes.
