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Kombiglyze XR
Kombiglyze XR is a combination medication that contains saxagliptin and metformin. It is used to improve blood sugar control in adults with type 2 diabetes. This medication is part of a comprehensive treatment plan that includes diet and exercise.
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Frequently Asked Questions
How long does it take for Kombiglyze XR to start working?
Patients may begin to see improvements in blood sugar levels within 1 to 2 weeks of starting treatment.
Can I take Kombiglyze XR with other medications?
Always consult your healthcare provider before combining Kombiglyze XR with other medications, especially other diabetes treatments.
What should I do if I miss a dose of Kombiglyze XR?
If you miss a dose, take it as soon as you remember on the same day. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use Kombiglyze XR during pregnancy?
Kombiglyze XR should be used during pregnancy only if clearly needed; consult a healthcare provider for alternatives.
Can Kombiglyze XR cause weight gain?
Weight gain is not commonly associated with Kombiglyze XR; in fact, metformin is often associated with weight neutrality or loss. Any significant changes in weight should be discussed with a healthcare provider.
Comprehensive Drug Guide
How Does Kombiglyze XR Work?
- Saxagliptin: Works by inhibiting the DPP-4 enzyme, which increases levels of incretin hormones. This leads to increased insulin secretion and decreased glucagon secretion, helping to lower blood sugar levels.
- Metformin: Reduces hepatic glucose production and increases insulin sensitivity, improving glucose uptake by the muscles and decreasing intestinal absorption of glucose.
Common Dosages
- Extended-release tablets: Common dosages include 5 mg saxagliptin/1000 mg metformin and 2.5 mg saxagliptin/1000 mg metformin.
Typical Dosing
- The usual starting dose is 5 mg saxagliptin and 1000 mg metformin taken once daily with the evening meal. Dosage may be adjusted based on blood sugar levels and tolerance.
Typical Dosing
FDA Approved Indications
- Management of type 2 diabetes in conjunction with diet and exercise to improve glycemic control in adults.
Who Shouldn't Take Kombiglyze XR?
- Known hypersensitivity to saxagliptin, metformin, or any components of the formulation
- Severe renal impairment or end-stage renal disease
- Acute or chronic metabolic acidosis, including diabetic ketoacidosis
Advice From The Pharmacist
- Patients should be advised to take Kombiglyze XR with food to minimize gastrointestinal side effects.
- Regular monitoring of blood glucose levels is important to assess the effectiveness of the medication.
- Discuss lifestyle modifications, including diet and exercise, as part of diabetes management.
Side Effects of Kombiglyze XR
Common Side Effects
- Gastrointestinal symptoms (nausea, vomiting, diarrhea)
- Headache
- Upper respiratory tract infections
Uncommon/Severe Side Effects
- Lactic acidosis (rare but serious)
- Pancreatitis
- Severe allergic reactions (anaphylaxis)
Risks and Warnings of Kombiglyze XR
- Lactic Acidosis: Patients with renal impairment or other risk factors for lactic acidosis should be monitored closely.
- Pancreatitis: Be alert for signs of pancreatitis, such as persistent abdominal pain, which may require discontinuation of the medication.
Interactions with Kombiglyze XR
Common Drug Interactions
- Other Antidiabetic Agents: Careful monitoring is required when Kombiglyze XR is used in combination with other antidiabetic medications to avoid hypoglycemia.
- Alcohol: Excessive alcohol consumption can increase the risk of lactic acidosis with metformin.
Alternatives to Kombiglyze XR
- Other DPP-4 Inhibitors: Such as sitagliptin for similar effects on blood sugar control.
- SGLT2 Inhibitors: Such as empagliflozin for an alternative mechanism of action in diabetes management.
