NiHowdy > Drug Classes > Cannabinoids

Browse Medications by Drug Class: Cannabinoids

Written by Amar Lunagaria

Pharm.D • NiHowdy Founder

Reviewed by James Wong

Pharm.D • NiHowdy Founder

Published Jan 15, 2025

Fact checked

What are Cannabinoids?

Cannabinoids are a class of compounds found in the cannabis plant, as well as synthetic versions, that interact with the body's endocannabinoid system (ECS). They influence various physiological processes, including pain perception, mood, appetite, and immune function. Common cannabinoids include tetrahydrocannabinol (THC), which is psychoactive, and cannabidiol (CBD), which is non-psychoactive. Cannabinoids are used to treat conditions such as chronic pain, epilepsy, and nausea associated with chemotherapy. A unique characteristic of cannabinoids is their ability to modulate the ECS, offering a therapeutic effect for a wide range of conditions. NiHowdy ensures affordable access to cannabinoid-based therapies for patients seeking relief.

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List of drugs in Cannabinoids

Drug Name	More Information	NiHowdy Prices & Bitcoin Rebate

Dronabinol	Dronabinol Information	Dronabinol Pricing
Marinol	Marinol Information	Marinol Pricing
Syndros	Syndros Information	Syndros Pricing

Brief history about Cannabinoids?

The use of cannabinoids dates back thousands of years, with cannabis being used in traditional medicine for pain relief, appetite stimulation, and spiritual practices. Modern research began in the mid-20th century with the discovery of THC in 1964 and the identification of the endocannabinoid system in the 1990s. These discoveries revolutionized our understanding of how cannabinoids interact with the body, leading to the development of medical cannabis and synthetic cannabinoids for therapeutic use. NiHowdy simplifies access to cannabinoid-based treatments, ensuring affordability and support for patients exploring this innovative therapy.

How do Cannabinoids work?

Cannabinoids work by interacting with the endocannabinoid system (ECS), a network of receptors, enzymes, and endocannabinoids in the body. The two primary receptors, CB1 and CB2, are located in the brain and immune system, respectively. THC binds to CB1 receptors, producing psychoactive effects and pain relief, while CBD modulates these receptors indirectly, providing anti-inflammatory and anxiolytic benefits without intoxication. Synthetic cannabinoids mimic these actions, offering targeted effects for medical use. NiHowdy ensures patients have access to these therapies affordably, empowering them to manage diverse health conditions.

What are Cannabinoids used to treat?

Chronic Pain

Cannabinoids, particularly THC and CBD, are used to manage chronic pain conditions, including neuropathic pain and pain associated with cancer. They provide relief by modulating pain signals in the central nervous system and reducing inflammation.

Epilepsy

CBD-based medications, such as Epidiolex, are FDA-approved for treating seizure disorders, including Lennox-Gastaut syndrome and Dravet syndrome. They reduce seizure frequency and improve quality of life for patients with drug-resistant epilepsy.

Chemotherapy-Induced Nausea and Vomiting

THC-based medications like dronabinol are used to alleviate nausea and vomiting caused by chemotherapy, improving appetite and overall well-being in cancer patients.

Anxiety and PTSD

CBD is often used to manage anxiety and symptoms of post-traumatic stress disorder (PTSD). It reduces hyperarousal, promotes relaxation, and improves sleep without causing intoxication.

Appetite Stimulation

THC-based medications are prescribed for appetite stimulation in patients with conditions like HIV/AIDS or cancer-related cachexia, helping to prevent severe weight loss.

Who should consider Cannabinoids medications?

Adults

Cannabinoids are commonly prescribed for adults with conditions such as chronic pain, multiple sclerosis, or chemotherapy-induced nausea. They provide effective relief for symptoms that are often resistant to traditional therapies.

Children

In pediatric cases, cannabinoids like CBD are used to manage severe seizure disorders, such as Dravet syndrome. Doses are carefully adjusted to ensure safety and efficacy, with close monitoring by a healthcare provider.

Seniors

Seniors benefit from cannabinoids for conditions like chronic pain, arthritis, or neurodegenerative diseases. These medications offer a non-opioid alternative for symptom relief, though careful dosing is essential to minimize side effects.

Are Cannabinoids safe?

Cannabinoids are generally safe when used under medical supervision. Common side effects include drowsiness, dizziness, dry mouth, and changes in appetite. THC may cause psychoactive effects, such as euphoria or anxiety, particularly at higher doses. CBD is better tolerated and associated with fewer side effects. Long-term use of THC may lead to dependency or tolerance, so usage should be closely monitored by a healthcare provider.

Can I take Cannabinoids during pregnancy?

The use of cannabinoids during pregnancy is generally not recommended due to potential risks to fetal development, including low birth weight and neurodevelopmental issues. Patients should consult their healthcare provider for safer alternatives during pregnancy.

Are Cannabinoids safe to take while lactating?

Cannabinoids, particularly THC, may transfer into breast milk and affect the nursing infant. Therefore, their use is generally discouraged during lactation. Patients should consult their healthcare provider to explore safer options.

Are Cannabinoids controlled substances?

THC is classified as a controlled substance in many regions due to its psychoactive properties. However, CBD and synthetic cannabinoids with no psychoactive effects are often classified differently or available by prescription. Patients should consult local regulations and their healthcare provider for guidance.

Side effects of Cannabinoids?

Common side effects of cannabinoids include drowsiness, dizziness, dry mouth, and changes in appetite. THC may cause psychoactive effects like euphoria, paranoia, or anxiety, especially at higher doses. Rare but serious risks include dependency or impaired cognitive function with long-term THC use. CBD is associated with fewer side effects but may cause mild gastrointestinal discomfort or fatigue. Patients should discuss potential side effects with their healthcare provider and report any severe or unusual symptoms.

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Cost considerations and insurance coverage for Cannabinoids

The cost of cannabinoid medications varies widely depending on the formulation and indication. FDA-approved options like Epidiolex and dronabinol are often covered by insurance for specific conditions, while medical cannabis may not be covered in all regions. NiHowdy offers discounts, rebates, and Bitcoin rewards to ensure cannabinoid therapies remain accessible and affordable for patients.

How do I get rebates on Cannabinoids?

NiHowdy's Bitcoin rebate program for cannabinoid prescriptions provides patients with a unique opportunity to save on healthcare costs while earning potential financial growth. This innovative approach makes managing conditions with cannabinoid therapies both affordable and rewarding, improving access to care while building long-term value.

Therapeutic Classes linked to Cannabinoids

Antiemetics (Nausea)

Medical Conditions treated by Cannabinoids

Nausea and Vomiting