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Dronabinol
Dronabinol is a synthetic form of delta-9-tetrahydrocannabinol (THC), the active ingredient found in cannabis (marijuana). It is used to treat nausea and vomiting caused by chemotherapy and to improve appetite in patients with AIDS-related wasting syndrome. Dronabinol works by interacting with the endocannabinoid system in the brain to help regulate appetite and reduce nausea. It is available in capsule form.
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Frequently Asked Questions
How long does it take for Dronabinol to start working?
Dronabinol typically begins working within 30 minutes to 1 hour after taking the medication, with peak effects occurring in 2-4 hours.
Can I drive after taking Dronabinol?
No, Dronabinol can cause drowsiness, dizziness, and impaired judgment, so avoid driving or operating heavy machinery until you know how it affects you.
Is Dronabinol addictive?
Dronabinol has the potential for abuse and dependence, especially in individuals with a history of substance abuse. It should be used as directed by a healthcare provider.
What should I do if I miss a dose of Dronabinol?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and take the next one as scheduled. Do not double up doses.
Can Dronabinol be used to treat pain?
Dronabinol is not specifically approved for pain relief, but it may help alleviate certain types of pain by reducing nausea and stimulating appetite. Always consult your doctor about its use for pain management.
Comprehensive Drug Guide
How Does Dronabinol Work?
Dronabinol works by activating cannabinoid receptors in the brain, which helps reduce nausea and vomiting and stimulates appetite. It mimics the action of natural cannabinoids, which play a role in regulating mood, appetite, and nausea.
Common Dosages
- Capsules: 2.5 mg, 5 mg, 10 mg
Typical Dosing
- For chemotherapy-induced nausea and vomiting: The typical dose is 5 mg/m², taken 1-3 hours before chemotherapy and then every 2-4 hours after chemotherapy for up to 6 doses per day.
- For appetite stimulation: The starting dose is 2.5 mg taken once or twice daily, with possible increases based on response.
Typical Dosing
FDA Approved Indications
- Chemotherapy-induced nausea and vomiting (when other treatments have failed)
- Appetite stimulation in patients with AIDS-related weight loss (wasting syndrome)
Who Shouldn't Take Dronabinol?
- Known hypersensitivity to cannabinoids or sesame oil (a component of the capsule)
- History of psychiatric disorders such as schizophrenia or psychosis
- Severe liver disease
Advice From The Pharmacist
- Dronabinol may cause drowsiness, dizziness, and euphoria, so avoid driving or operating heavy machinery until you know how it affects you.
- Store the capsules in a cool, dry place, and do not use if they have expired.
- Avoid alcohol while taking Dronabinol, as it can increase the sedative effects.
- Take Dronabinol exactly as prescribed and do not exceed the recommended dose.
Side Effects of Dronabinol
Common Side Effects
- Drowsiness
- Dizziness
- Euphoria (feeling "high")
- Dry mouth
Uncommon/Severe Side Effects
- Paranoia or hallucinations
- Severe dizziness or fainting
- Rapid heartbeat
Risks and Warnings of Dronabinol
- Mental Health Risks: Dronabinol can cause psychiatric symptoms such as paranoia, anxiety, or hallucinations, particularly in individuals with a history of mental health disorders.
- Heart Rate Changes: Dronabinol may increase heart rate, so caution is advised in patients with heart disease.
- Potential for Abuse: As a Schedule III controlled substance, Dronabinol has the potential for abuse and dependence. It should be used exactly as prescribed.
Interactions with Dronabinol
Common Drug Interactions
- CNS depressants: Combining Dronabinol with other central nervous system depressants (e.g., alcohol, benzodiazepines) may increase drowsiness and dizziness.
- Blood pressure medications: Dronabinol may interact with medications used to lower blood pressure, potentially causing hypotension.
- Antidepressants: Dronabinol may interact with antidepressants, increasing the risk of serotonin syndrome.
Alternatives to Dronabinol
- Nabilone (Cesamet): Another synthetic cannabinoid used for nausea and vomiting caused by chemotherapy.
- Megestrol acetate: An appetite stimulant used for AIDS-related weight loss.
- Ondansetron (Zofran): A non-cannabinoid antiemetic commonly used for nausea and vomiting related to chemotherapy.
