Browse Medications by Drug Class: Calcineurin Inhibitors

Autoimmune Diseases

These medications are used to manage autoimmune conditions such as rheumatoid arthritis, lupus nephritis, and myasthenia gravis. By suppressing the overactive immune response, calcineurin inhibitors help reduce inflammation and prevent tissue damage.

Psoriasis

Topical calcineurin inhibitors, such as tacrolimus and pimecrolimus, are used to treat psoriasis and other chronic inflammatory skin conditions. They reduce skin inflammation and improve symptoms without the side effects of systemic immunosuppressants.

Organ Transplant Rejection Prevention

Calcineurin inhibitors like cyclosporine and tacrolimus are essential in preventing rejection of transplanted organs such as kidneys, livers, hearts, and lungs. They suppress the immune system, reducing the risk of the body attacking the transplanted tissue and ensuring graft survival.

Atopic Dermatitis (Eczema)

In atopic dermatitis, calcineurin inhibitors are applied topically to reduce itching, redness, and inflammation. They are particularly beneficial for sensitive areas like the face and eyelids, where steroid use may be problematic.

Adults

Calcineurin inhibitors are frequently prescribed for adults undergoing organ transplantation or managing autoimmune diseases such as rheumatoid arthritis or lupus nephritis. They provide effective immune suppression to prevent organ rejection and control inflammation. Adults with chronic inflammatory conditions like atopic dermatitis or psoriasis may also benefit from topical formulations.

Children

In pediatric cases, calcineurin inhibitors are used to manage organ rejection after transplantation and to treat autoimmune conditions such as juvenile idiopathic arthritis or severe eczema. Dosages are carefully adjusted based on the child's weight and age to ensure safety and efficacy.

Seniors

Seniors benefit from calcineurin inhibitors in transplant management and autoimmune disease control. However, they require close monitoring for side effects like kidney dysfunction or hypertension, as age-related changes in metabolism can increase the risk of adverse effects. Regular follow-ups ensure safe and effective treatment in this population.