Browse Medications by Drug Class: Calcineurin Inhibitors

Written by Amar Lunagaria
Pharm.D • NiHowdy Founder

Reviewed by James Wong
Pharm.D • NiHowdy Founder
Published Jan 15, 2025

What are Calcineurin Inhibitors?
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List of drugs in Calcineurin Inhibitors
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Brief history about Calcineurin Inhibitors?
How do Calcineurin Inhibitors work?
What are Calcineurin Inhibitors used to treat?
Autoimmune Diseases
These medications are used to manage autoimmune conditions such as rheumatoid arthritis, lupus nephritis, and myasthenia gravis. By suppressing the overactive immune response, calcineurin inhibitors help reduce inflammation and prevent tissue damage.
Psoriasis
Topical calcineurin inhibitors, such as tacrolimus and pimecrolimus, are used to treat psoriasis and other chronic inflammatory skin conditions. They reduce skin inflammation and improve symptoms without the side effects of systemic immunosuppressants.
Organ Transplant Rejection Prevention
Calcineurin inhibitors like cyclosporine and tacrolimus are essential in preventing rejection of transplanted organs such as kidneys, livers, hearts, and lungs. They suppress the immune system, reducing the risk of the body attacking the transplanted tissue and ensuring graft survival.
Atopic Dermatitis (Eczema)
In atopic dermatitis, calcineurin inhibitors are applied topically to reduce itching, redness, and inflammation. They are particularly beneficial for sensitive areas like the face and eyelids, where steroid use may be problematic.
Who should consider Calcineurin Inhibitors medications?
Adults
Calcineurin inhibitors are frequently prescribed for adults undergoing organ transplantation or managing autoimmune diseases such as rheumatoid arthritis or lupus nephritis. They provide effective immune suppression to prevent organ rejection and control inflammation. Adults with chronic inflammatory conditions like atopic dermatitis or psoriasis may also benefit from topical formulations.
Children
In pediatric cases, calcineurin inhibitors are used to manage organ rejection after transplantation and to treat autoimmune conditions such as juvenile idiopathic arthritis or severe eczema. Dosages are carefully adjusted based on the child's weight and age to ensure safety and efficacy.
Seniors
Seniors benefit from calcineurin inhibitors in transplant management and autoimmune disease control. However, they require close monitoring for side effects like kidney dysfunction or hypertension, as age-related changes in metabolism can increase the risk of adverse effects. Regular follow-ups ensure safe and effective treatment in this population.
Are Calcineurin Inhibitors safe?
Can I take Calcineurin Inhibitors during pregnancy?
Are Calcineurin Inhibitors safe to take while lactating?
Are Calcineurin Inhibitors controlled substances?
Side effects of Calcineurin Inhibitors?
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