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Nujo
Nujo (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated for the treatment of type 2 diabetes mellitus. It is designed to improve glycemic control and may also assist with weight management in adults. Nujo mimics the action of the GLP-1 hormone, which stimulates insulin secretion, decreases glucagon release, and slows gastric emptying.
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Frequently Asked Questions
How quickly does Nujo work?
Patients may begin to see improvements in blood sugar levels within a few weeks, but optimal effects may take longer.
Can I take Nujo with food?
Yes, Nujo can be taken with or without food. Consistency in dosing time is more important than timing with meals.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember within 5 days of your regular dosing day. If it’s been more than 5 days, skip the missed dose and continue with your regular schedule.
Is Nujo safe during pregnancy?
Nujo should be used during pregnancy only if the potential benefits justify the potential risks. Consult your healthcare provider for guidance.
What are the signs of serious side effects to watch for?
Monitor for signs of severe allergic reactions, pancreatitis, or thyroid tumors, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Nujo Work?
- Increases insulin secretion in response to meals.
- Decreases glucagon secretion, reducing hepatic glucose production.
- Slows gastric emptying, which helps decrease postprandial blood sugar levels.
- Enhances satiety, aiding in weight loss.
Common Dosages
- Pre-filled pen: Available in various doses, such as 0.25 mg, 0.5 mg, and 1 mg.
Typical Dosing
- Adults: The initial recommended dose is 0.25 mg once weekly for 4 weeks, which may be increased to 0.5 mg once weekly. After at least 4 weeks on the 0.5 mg dose, it may be further increased to 1 mg once weekly, based on individual needs and tolerability.
Typical Dosing
FDA Approved Indications
- Improvement of glycemic control in adults with type 2 diabetes mellitus.
- Weight management in conjunction with a reduced-calorie diet and increased physical activity.
Who Shouldn't Take Nujo?
- Known hypersensitivity to semaglutide or any component of the formulation.
- Personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Advice From The Pharmacist
- Administer Nujo once weekly on the same day each week, at any time of day, with or without meals.
- Rotate injection sites within the abdomen, thigh, or upper arm to minimize irritation.
- Monitor blood sugar levels regularly to assess treatment effectiveness.
Side Effects of Nujo
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
Uncommon/Severe Side Effects
- Pancreatitis
- Thyroid tumors
- Severe allergic reactions
Risks and Warnings of Nujo
- Pancreatitis: Monitor for signs of pancreatitis, such as severe abdominal pain, which may require discontinuation of the medication.
- Thyroid Tumors: There is a potential risk of thyroid C-cell tumors; discuss this risk with your healthcare provider.
Interactions with Nujo
Common Drug Interactions
- Other Antidiabetic Medications: Use with caution when combining with insulin or sulfonylureas, as this may increase the risk of hypoglycemia.
- Medications Affecting Gastrointestinal Motility: Discuss with your healthcare provider if you are taking other medications that may affect digestion.
Alternatives to Nujo
- Other GLP-1 Receptor Agonists: Such as liraglutide or dulaglutide for similar indications.
- Insulin Therapy: For patients requiring additional glycemic control.
