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Protopic
Protopic (generic name: tacrolimus) is a topical immunosuppressant used to treat moderate to severe atopic dermatitis (eczema) in patients who have not responded well to other treatments. It works by reducing inflammation in the skin and suppressing the immune system’s response, helping to relieve symptoms like itching, redness, and swelling. Protopic is available in two strengths and is used in both adults and children aged 2 years and older.
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Frequently Asked Questions
How long does it take for Protopic to work?
Improvement in eczema symptoms is usually seen within a week of starting treatment, but full effects may take longer. If no improvement is seen after several weeks, consult your healthcare provider.
Can Protopic be used long-term?
Protopic is typically used for short-term or intermittent long-term use. It is not recommended for continuous long-term use due to potential risks of skin cancer and lymphoma, though the risk is low.
Can Protopic be used on the face?
Yes, Protopic is often used to treat eczema on the face, including sensitive areas like the eyelids. However, use caution and follow your healthcare provider’s directions.
Can children use Protopic?
Yes, Protopic is approved for use in children aged 2 years and older. The 0.03% strength is typically prescribed for children, while the 0.1% strength is reserved for adults and older teens.
What should I do if I miss a dose?
Apply the missed dose as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Comprehensive Drug Guide
How Does Protopic Work?
Protopic works by inhibiting the activity of calcineurin, a protein that activates T-cells in the immune system. By blocking calcineurin, tacrolimus reduces the immune response in the skin, decreasing inflammation and helping to relieve symptoms of eczema.
Common Dosages
- 0.03% ointment: Typically prescribed for children aged 2 to 15 years.
- 0.1% ointment: Typically prescribed for adults and children over 16 years.
Typical Dosing
- For adults and children over 16 years: Apply 0.1% ointment twice daily to affected areas until symptoms improve, then reduce application frequency or discontinue as needed.
- For children aged 2 to 15 years: Apply 0.03% ointment twice daily to affected areas.
Typical Dosing
FDA Approved Indications
- Atopic dermatitis (eczema) in patients who are not responsive to other treatments, including topical corticosteroids.
Who Shouldn't Take Protopic?
- Known hypersensitivity to tacrolimus or any of the ointment’s ingredients.
- Weakened immune systems, as Protopic can further suppress immune function.
Advice From The Pharmacist
- Use Protopic exactly as prescribed. Do not use it for longer than recommended by your healthcare provider, and avoid using it on areas of the skin that are infected.
- Do not cover the treated areas with bandages or dressings unless advised by your healthcare provider.
- Avoid sunlight and UV light exposure (such as tanning beds) while using Protopic, as it can make the skin more sensitive to the sun. Wear protective clothing and sunscreen if needed.
- If you develop any signs of skin infection (such as redness, swelling, or pus), contact your healthcare provider immediately.
Side Effects of Protopic
Common Side Effects
- Burning or stinging at the application site
- Itching
- Redness
- Headache
Uncommon/Severe Side Effects
- Increased risk of skin infections
- Skin cancer or lymphoma (with long-term use, though the risk is very low)
- Severe allergic reactions (e.g., swelling, difficulty breathing)
Risks and Warnings of Protopic
- Skin Cancer and Lymphoma: There have been rare reports of skin cancer and lymphoma in patients using Protopic. The long-term safety of Protopic is not fully established, so it should only be used as directed by a healthcare provider.
- Increased Risk of Infections: Since Protopic suppresses the immune response, it may increase the risk of skin infections. Avoid using it on infected skin and inform your healthcare provider if you notice any signs of infection.
Interactions with Protopic
Common Drug Interactions
- Other topical treatments: Using multiple topical medications at the same time may increase irritation or the risk of infection.
- UV light therapy: Avoid combining Protopic with light therapy (e.g., phototherapy) due to the increased risk of skin damage.
Alternatives to Protopic
- Elidel (pimecrolimus): Another topical calcineurin inhibitor used to treat eczema.
- Topical corticosteroids: Often used as a first-line treatment for eczema.
- Moisturizing creams and ointments: Help manage eczema by keeping the skin hydrated and preventing flare-ups.
