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Verkazia
Verkazia (generic name: cyclosporine ophthalmic emulsion) is an anti-inflammatory eye drop used to treat vernal keratoconjunctivitis (VKC), a severe form of allergic conjunctivitis that primarily affects children and young adults. VKC is characterized by chronic inflammation of the eye, leading to discomfort, redness, and potential damage to the cornea. Verkazia works by suppressing the immune response that causes the inflammation, helping to reduce symptoms and protect the eyes from damage.
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Frequently Asked Questions
How long does it take for Verkazia to work?
Verkazia may take several weeks to start showing significant improvements in symptoms. It is important to continue using the drops as prescribed, even if you don’t see immediate relief.
Can I wear contact lenses while using Verkazia?
You should remove contact lenses before applying Verkazia and wait at least 15 minutes before reinserting them. The medication may adhere to the lenses and cause discomfort.
What should I do if I miss a dose of Verkazia?
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Can Verkazia be used long-term?
Verkazia is designed for long-term use in patients with vernal keratoconjunctivitis. However, regular follow-up appointments with your healthcare provider are important to monitor the treatment’s effectiveness and safety.
Is Verkazia safe for children?
Yes, Verkazia is approved for use in children aged 4 years and older. It is commonly used to treat VKC in pediatric patients, but it should be used under the supervision of a healthcare provider.
Comprehensive Drug Guide
How Does Verkazia Work?
Verkazia contains cyclosporine, an immunosuppressive agent that works by inhibiting the activity of T-cells, which are part of the immune system. In VKC, overactive T-cells cause chronic inflammation of the conjunctiva and cornea. By reducing T-cell activity, Verkazia decreases inflammation, redness, and swelling, thereby alleviating the symptoms of VKC and preventing long-term eye damage.
Common Dosages
- 1 mg/mL ophthalmic emulsion in single-dose vials.
Typical Dosing
- The typical dose is 1 drop in each affected eye 4 times daily (morning, noon, afternoon, and evening). Treatment duration depends on the patient’s symptoms and response to the medication, but regular follow-up with a healthcare provider is required.
Typical Dosing
FDA Approved Indications
- Treatment of vernal keratoconjunctivitis (VKC) in children and adults aged 4 years and older.
Who Shouldn't Take Verkazia?
Known hypersensitivity to cyclosporine or any of the ingredients in Verkazia.
Advice From The Pharmacist
- Use Verkazia exactly as prescribed, applying one drop to each affected eye 4 times a day. It is important to use the drops at regular intervals for maximum effectiveness.
- Wash your hands before applying the drops, and avoid touching the tip of the vial to your eye or any surface to prevent contamination.
- Discard the single-dose vial after each use, even if there is leftover liquid, as it is not intended for reuse.
- If you wear contact lenses, remove them before using Verkazia. Wait at least 15 minutes before reinserting your lenses.
- If you use multiple eye drops, allow at least 5 minutes between applying each medication.
Side Effects of Verkazia
Common Side Effects
- Eye pain or discomfort (usually temporary after application)
- Redness of the eyes
- Blurred vision
Uncommon/Severe Side Effects
- Severe eye irritation or allergic reactions (swelling, itching, rash, difficulty breathing)
Risks and Warnings of Verkazia
- Local Eye Irritation: Verkazia may cause temporary eye discomfort or irritation when first applied. This is generally mild and resolves quickly. If irritation persists or worsens, contact your healthcare provider.
- Infection Risk: Because Verkazia suppresses the immune response in the eyes, patients using it may be at increased risk for eye infections. Contact your doctor if you notice any signs of infection, such as increased redness, swelling, or discharge.
Interactions with Verkazia
Common Drug Interactions
- Contact lenses: Remove contact lenses before applying Verkazia, as the emulsion may adhere to the lenses and cause discomfort.
- Other eye medications: If using multiple ophthalmic medications, allow at least 5 minutes between each application to ensure proper absorption of each medication.
Alternatives to Verkazia
- Restasis (cyclosporine ophthalmic emulsion): Another cyclosporine-based eye drop used primarily to treat dry eye disease, but sometimes used for other inflammatory eye conditions.
- Topical corticosteroids: Steroid eye drops may be used short-term for VKC, but long-term use is generally avoided due to the risk of side effects like increased intraocular pressure.
- Antihistamine eye drops: Often used to reduce itching and irritation in milder cases of allergic conjunctivitis.