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Vraylar
Vraylar (generic name: cariprazine) is an atypical antipsychotic used to treat schizophrenia, bipolar disorder, and bipolar depression in adults. It helps manage symptoms such as hallucinations, delusions, mood swings, and depression by balancing neurotransmitters in the brain, particularly dopamine and serotonin. Vraylar is particularly beneficial for treating both manic and depressive episodes in bipolar disorder.
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Frequently Asked Questions
How long does it take for Vraylar to start working?
It may take several weeks to feel the full effects of Vraylar. Some people may start to notice improvements in symptoms within the first few days, but it’s important to continue taking the medication as prescribed.
Can Vraylar cause weight gain?
Yes, weight gain is a possible side effect of Vraylar. Your healthcare provider may monitor your weight and metabolic health during treatment.
What should I do if I miss a dose of Vraylar?
If you miss a dose, take it as soon as you remember unless it’s close to your next scheduled dose. Do not double up on doses to make up for a missed one.
Can I drink alcohol while taking Vraylar?
It’s best to avoid alcohol while taking Vraylar, as it can increase the risk of side effects such as dizziness and drowsiness.
Is Vraylar safe for long-term use?
Vraylar can be used long-term under the supervision of a healthcare provider. Regular monitoring is important to assess the drug’s effectiveness and manage potential long-term side effects, such as tardive dyskinesia.
Comprehensive Drug Guide
How Does Vraylar Work?
Vraylar works by acting as a partial agonist at dopamine D2 and D3 receptors and serotonin 5-HT1A receptors, while acting as an antagonist at serotonin 5-HT2A receptors. This helps balance dopamine and serotonin activity in the brain, which can reduce symptoms of psychosis, mood swings, and depression associated with schizophrenia and bipolar disorder.
Common Dosages
- 1.5 mg, 3 mg, 4.5 mg, and 6 mg capsules
Typical Dosing
- Schizophrenia: The starting dose is 1.5 mg once daily, which may be increased based on response. The recommended dose range is 1.5 mg to 6 mg per day.
- Bipolar I Disorder (manic or mixed episodes): The starting dose is 1.5 mg daily, which can be increased to 3 mg to 6 mg daily, depending on clinical response.
- Bipolar Depression: The typical starting dose is 1.5 mg once daily, with a target dose of 1.5 mg to 3 mg daily.
Typical Dosing
FDA Approved Indications
- Treatment of schizophrenia in adults
- Treatment of manic or mixed episodes associated with bipolar I disorder in adults
- Treatment of bipolar depression in adults
Who Shouldn't Take Vraylar?
- Known hypersensitivity to cariprazine or any components of the formulation.
- Dementia-related psychosis, as it increases the risk of death in elderly patients with this condition.
Advice From The Pharmacist
- Take Vraylar as prescribed, with or without food. Consistency is key for managing symptoms effectively.
- It may take several weeks for Vraylar to reach its full effect, so continue taking it even if you don’t notice an immediate improvement.
- Avoid alcohol while taking Vraylar, as it can increase the risk of side effects.
- Contact your healthcare provider if you experience symptoms such as uncontrollable movements, as Vraylar may cause movement disorders (extrapyramidal symptoms).
Side Effects of Vraylar
Common Side Effects
- Drowsiness or fatigue
- Nausea
- Restlessness (akathisia)
- Dizziness
- Weight gain
Uncommon/Severe Side Effects
- Extrapyramidal symptoms (EPS), such as tremors or muscle stiffness
- Tardive dyskinesia (involuntary movements of the face or body)
- Neuroleptic malignant syndrome (NMS), a rare but life-threatening condition
- Metabolic changes, such as increased blood sugar or cholesterol levels
Risks and Warnings of Vraylar
- Tardive Dyskinesia: Vraylar may cause involuntary, repetitive movements, especially with long-term use. This condition can be irreversible, so regular monitoring is essential.
- Neuroleptic Malignant Syndrome (NMS): Rare but serious condition characterized by fever, muscle stiffness, and confusion. Immediate medical attention is required if symptoms occur.
- Metabolic Changes: Vraylar can lead to significant weight gain, elevated blood sugar, and changes in cholesterol levels. Regular monitoring of metabolic health is recommended.
Interactions with Vraylar
Common Drug Interactions
- CYP3A4 inhibitors (e.g., ketoconazole): May increase Vraylar levels and the risk of side effects. Dosage adjustments may be necessary.
- CYP3A4 inducers (e.g., rifampin): May reduce the effectiveness of Vraylar by lowering its blood levels.
- Other CNS depressants: Combining Vraylar with other medications that affect the central nervous system (such as sedatives) may increase drowsiness or dizziness.
Alternatives to Vraylar
- Abilify (aripiprazole): Another atypical antipsychotic that works similarly by modulating dopamine and serotonin receptors.
- Latuda (lurasidone): An atypical antipsychotic often used for bipolar depression and schizophrenia.
- Seroquel (quetiapine): A widely used atypical antipsychotic for treating schizophrenia and bipolar disorder.
- Rexulti (brexpiprazole): An antipsychotic similar to Vraylar, used for schizophrenia and major depressive disorder.