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Latuda
Latuda, the brand name for lurasidone, is an atypical antipsychotic used to treat mental health conditions such as schizophrenia and bipolar depression. It works by balancing certain neurotransmitters in the brain, such as dopamine and serotonin, which helps manage symptoms like hallucinations, mood swings, and depressive episodes. Latuda is prescribed to adults and adolescents and is often part of a comprehensive treatment plan that includes therapy and support.
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Frequently Asked Questions
How long does it take for Latuda to work?
Latuda may start improving symptoms within 1 to 2 weeks, but it can take up to 6 weeks for full effects to be seen.
Can I stop taking Latuda once I feel better?
No, do not stop taking Latuda without consulting your doctor. Stopping the medication suddenly may lead to withdrawal symptoms or a relapse of your condition.
What should I do if I miss a dose of Latuda?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Latuda safe for children?
Yes, Latuda is approved for the treatment of schizophrenia in adolescents aged 13 and older and for bipolar depression in children aged 10 and older. However, there is a risk of increased suicidal thoughts in young patients, so close monitoring is essential.
Can Latuda cause weight gain?
Yes, weight gain is a potential side effect of Latuda, although it is considered to have a lower risk of significant weight gain compared to other antipsychotics like olanzapine. Monitoring of weight and metabolic changes is recommended during treatment.
Comprehensive Drug Guide
How Does Latuda Work?
Latuda works by acting as a dopamine D2 receptor antagonist and a serotonin 5-HT2A receptor antagonist. By blocking these receptors, Latuda helps reduce the symptoms of schizophrenia and bipolar disorder, such as hallucinations, disorganized thinking, mood swings, and depressive symptoms. It also modulates other neurotransmitters, helping improve mood and cognitive function.
Common Dosages
- 20 mg, 40 mg, 60 mg, 80 mg, and 120 mg oral tablets.
The starting dose and maintenance dose vary depending on the condition being treated.
Typical Dosing
- For schizophrenia (adults): The usual starting dose is 40 mg once daily, which may be adjusted based on the patient's response, up to a maximum of 160 mg per day.
- For bipolar depression (adults): The typical starting dose is 20 mg to 40 mg once daily, with a maximum dose of 120 mg per day.
- For adolescents (schizophrenia or bipolar depression): Dosing is typically lower and adjusted according to the patient's weight and response.
Latuda should be taken with food (at least 350 calories) to ensure proper absorption.
Typical Dosing
FDA Approved Indications
- Treatment of schizophrenia in adults and adolescents aged 13 years and older.
- Treatment of bipolar depression (bipolar I disorder) as monotherapy or as an adjunct to lithium or valproate in adults and pediatric patients aged 10 years and older.
Who Shouldn't Take Latuda?
- Known hypersensitivity or allergy to lurasidone or any component of the formulation.
- Concomitant use of strong CYP3A4 inhibitors (such as ketoconazole) or inducers (such as rifampin), as these drugs can significantly affect Latuda's effectiveness.
Advice From The Pharmacist
- Take Latuda with food: Ensure you consume at least 350 calories with your dose to maximize absorption.
- Avoid alcohol while taking Latuda, as it can increase the risk of side effects like dizziness, drowsiness, and impaired judgment.
- Stick to a regular dosing schedule to maintain consistent levels of the medication in your body. Do not stop taking Latuda suddenly without consulting your doctor, as this can lead to withdrawal symptoms or worsening of your condition.
- Be cautious with activities that require mental alertness, such as driving, until you know how Latuda affects you.
- Store Latuda at room temperature and keep it out of reach of children.
Side Effects of Latuda
Common Side Effects
- Drowsiness
- Nausea
- Weight gain
- Akathisia (restlessness)
- Dizziness
Uncommon/Severe Side Effects
- Increased risk of suicidal thoughts in young adults and children.
- Neuroleptic malignant syndrome (NMS), a rare but potentially life-threatening condition that causes muscle rigidity, fever, and confusion.
- Tardive dyskinesia, a condition that causes involuntary movements, particularly of the face and tongue.
- Metabolic changes such as increased blood sugar, cholesterol, or triglycerides.
Risks and Warnings of Latuda
- Increased Suicidal Thoughts: Latuda may increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults. Regular monitoring is important during the early stages of treatment.
- Neuroleptic Malignant Syndrome (NMS): A rare but serious reaction characterized by muscle rigidity, altered mental status, and high fever. Immediate medical attention is required if these symptoms develop.
- Tardive Dyskinesia: Latuda can cause involuntary movements, especially in long-term use. Contact your healthcare provider if you notice uncontrollable movements of the face or limbs.
- Metabolic Changes: Latuda can cause changes in blood sugar, lipids, and body weight. Regular monitoring of blood glucose and cholesterol levels may be necessary, especially in patients with diabetes or at risk for metabolic syndrome.
Interactions with Latuda
Common Drug Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): Can increase the levels of Latuda in the blood, leading to an increased risk of side effects.
- Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): Can decrease the effectiveness of Latuda by lowering its levels in the blood.
- CNS depressants (e.g., alcohol, sedatives): May increase drowsiness or dizziness when combined with Latuda.
Alternatives to Latuda
- Risperidone (Risperdal): Another atypical antipsychotic used for schizophrenia and bipolar disorder.
- Quetiapine (Seroquel): An atypical antipsychotic used for the treatment of schizophrenia and bipolar disorder.
- Olanzapine (Zyprexa): Another antipsychotic used for the treatment of schizophrenia and bipolar disorder.
- Aripiprazole (Abilify): An atypical antipsychotic used for schizophrenia, bipolar disorder, and adjunct treatment for depression.
