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RisperDAL

RisperDAL (generic name: risperidone) is a prescription atypical antipsychotic medication used to treat various psychiatric disorders, including schizophrenia, bipolar disorder, and irritability associated with autistic disorder in children and adolescents. RisperDAL works by affecting the levels of certain neurotransmitters in the brain, particularly dopamine and serotonin, helping to improve mood, thinking, and behavior. It is effective in reducing symptoms such as hallucinations, delusions, mood swings, and aggression.

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Frequently Asked Questions

How long does it take for RisperDAL to start working?
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Some individuals may start to feel improvements in their symptoms within 1 to 2 weeks, but it can take up to 4 to 6 weeks for the full effects to be seen.

Can RisperDAL cause weight gain?
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Yes, weight gain is a common side effect of RisperDAL, particularly with long-term use. It is important to monitor your weight and discuss any concerns with your doctor.

What should I do if I miss a dose of RisperDAL?
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If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and take your next dose as scheduled. Do not double up on doses.

Can RisperDAL be used in children?
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Yes, RisperDAL is approved for use in children and adolescents for treating irritability associated with autism and schizophrenia, but the dose may be adjusted based on the child’s weight and condition.

Is RisperDAL safe for long-term use?
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RisperDAL can be used for long-term management of conditions like schizophrenia and bipolar disorder, but it requires regular monitoring for side effects such as tardive dyskinesia, weight gain, and metabolic changes.

Comprehensive Drug Guide

How Does RisperDAL Work?

RisperDAL works by blocking dopamine D2 receptors and serotonin 5-HT2A receptors in the brain. This action helps to regulate mood, reduce psychotic symptoms such as hallucinations and delusions, and control mood swings and irritability. The medication’s impact on both dopamine and serotonin pathways makes it effective for managing both positive symptoms (like hallucinations) and negative symptoms (like social withdrawal) of schizophrenia and mood disorders.

Common Dosages

  • Tablets: 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg
  • Oral solution: 1 mg/mL
  • Orally disintegrating tablets: 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg
  • Long-acting injectable (RisperDAL Consta): 12.5 mg, 25 mg, 37.5 mg, and 50 mg (administered every two weeks)

Typical Dosing

  • For schizophrenia: The typical starting dose is 2 mg per day, which may be increased gradually based on response and tolerance. The usual maintenance dose is between 4 mg to 8 mg per day.
  • For bipolar disorder: The starting dose is 2 mg to 3 mg once daily for adults. Dosing adjustments are made based on the individual’s response, with a typical range of 1 mg to 6 mg per day.
  • For irritability associated with autistic disorder: The starting dose for children is 0.25 mg per day for those under 20 kg and 0.5 mg per day for those 20 kg or over, with gradual increases depending on response.
  • Long-acting injectable (RisperDAL Consta): Administered every two weeks by a healthcare professional, with the dose depending on the condition and individual needs.

Typical Dosing

FDA Approved Indications

  • Schizophrenia in adults and adolescents aged 13 years and older
  • Bipolar disorder for the treatment of acute manic or mixed episodes in adults and children aged 10 years and older
  • Irritability associated with autistic disorder in children and adolescents aged 5 to 16 years

Who Shouldn't Take RisperDAL?

  • Known hypersensitivity to risperidone or any component of the formulation.
  • Severe central nervous system (CNS) depression or comatose states.

Advice From The Pharmacist

  • Take RisperDAL exactly as prescribed, and try to take it at the same time every day. It can be taken with or without food.
  • If using the oral solution, do not mix it with tea or cola, as it may affect the medication’s effectiveness. Instead, mix it with water, coffee, orange juice, or low-fat milk.
  • Do not stop taking RisperDAL suddenly, as this can lead to withdrawal symptoms. Your doctor will guide you on how to taper the medication safely if necessary.
  • Store RisperDAL at room temperature, away from moisture and heat.
  • Avoid alcohol while taking RisperDAL, as it can increase side effects such as drowsiness or dizziness.
  • Regular monitoring of weight, blood glucose, and cholesterol is recommended, as RisperDAL can increase the risk of metabolic changes.

Side Effects of RisperDAL

Common Side Effects

  • Drowsiness or sedation
  • Weight gain
  • Dizziness or lightheadedness
  • Increased appetite
  • Fatigue
  • Constipation

Uncommon/Severe Side Effects

  • Tardive dyskinesia: Involuntary muscle movements, especially in the face, that may become permanent.
  • Neuroleptic malignant syndrome (NMS): A rare but serious condition characterized by high fever, muscle stiffness, confusion, and sweating.
  • High blood sugar or diabetes: RisperDAL may raise blood glucose levels, particularly in patients with a history of diabetes.
  • Increased risk of stroke: Elderly patients with dementia-related psychosis are at a higher risk of death and stroke when taking antipsychotic medications, including RisperDAL.

Risks and Warnings of RisperDAL

  • Increased Mortality in Elderly Patients with Dementia-Related Psychosis: RisperDAL is not approved for the treatment of dementia-related psychosis due to an increased risk of death, primarily from cardiovascular or infectious causes.
  • Tardive Dyskinesia: Long-term use of RisperDAL can lead to tardive dyskinesia, which involves involuntary, repetitive movements of the face or body. The risk increases with prolonged use.
  • Hyperglycemia and Diabetes: RisperDAL can cause significant increases in blood sugar levels. Patients with a history of diabetes or risk factors for diabetes should have their blood sugar monitored regularly.
  • Orthostatic Hypotension: RisperDAL can cause a drop in blood pressure when standing, leading to dizziness or fainting. Patients should be cautious when standing up from a seated or lying position.

Interactions with RisperDAL

Common Drug Interactions

  • CNS depressants (e.g., alcohol, sedatives, opioids): Combining RisperDAL with other CNS depressants can increase the risk of drowsiness, dizziness, and impaired coordination.
  • Levodopa and dopamine agonists: These medications may decrease the effectiveness of RisperDAL in treating symptoms of psychosis.
  • Antihypertensive medications: RisperDAL can enhance the blood pressure-lowering effects of antihypertensive drugs, increasing the risk of hypotension.

Alternatives to RisperDAL

  • Abilify (aripiprazole): Another atypical antipsychotic used for schizophrenia, bipolar disorder, and irritability associated with autism.
  • Seroquel (quetiapine): An antipsychotic used for schizophrenia, bipolar disorder, and depression.
  • Zyprexa (olanzapine): An atypical antipsychotic used for schizophrenia and bipolar disorder.
  • Latuda (lurasidone): Another atypical antipsychotic used to treat schizophrenia and bipolar depression.