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Lurasidone HCl

Lurasidone HCl is an atypical antipsychotic used primarily to treat schizophrenia and bipolar disorder in adults and adolescents. It helps to improve mood, reduce psychotic symptoms, and stabilize mood swings. Lurasidone is thought to work by modulating the effects of various neurotransmitters in the brain, particularly dopamine and serotonin.

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Frequently Asked Questions

How long does it take for Lurasidone to work?
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Patients may start to notice improvements within a few weeks, but it can take several weeks to achieve the full effect.

Can I take Lurasidone with other medications?
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Always inform your healthcare provider of all medications you are taking to avoid potential interactions.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up doses.

Are there any dietary restrictions while taking Lurasidone?
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Lurasidone should be taken with food (at least 350 calories) to ensure proper absorption.

Is Lurasidone safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Lurasidone.

Comprehensive Drug Guide

How Does Lurasidone HCl Work?

Lurasidone works by antagonizing (blocking) dopamine D2 receptors and serotonin 5-HT2A receptors while partially agonizing serotonin 5-HT1A receptors. This unique action helps to balance the neurotransmitter activity in the brain, reducing symptoms of psychosis and stabilizing mood without causing significant sedation or extrapyramidal side effects common with older antipsychotics.

Common Dosages

  • Tablets: 20 mg, 40 mg, 60 mg, 80 mg, and 120 mg.

Typical Dosing

  • For schizophrenia: The typical starting dose is 40 mg once daily, which may be adjusted based on response and tolerability, with a maximum dose of 80 mg per day.
  • For bipolar depression: The recommended starting dose is 20 mg once daily, with a maximum dose of 120 mg per day.


Typical Dosing

FDA Approved Indications

  • Schizophrenia: treatment in adults and adolescents aged 13 and older.
  • Bipolar depression: as an adjunct to mood stabilizers or antidepressants in adults.


Who Shouldn't Take Lurasidone HCl?

  • Known hypersensitivity to lurasidone or any component of the formulation.
  • Severe liver impairment.


Advice From The Pharmacist

  • Take Lurasidone HCl with food (at least 350 calories) to enhance absorption.
  • Monitor for any side effects, especially during the initial treatment phase or when adjusting dosages.
  • Be aware of the potential for metabolic changes, including weight gain and changes in blood sugar and cholesterol levels.


Side Effects of Lurasidone HCl

Common Side Effects

  • Drowsiness or sedation
  • Nausea
  • Akathisia (restlessness)
  • Weight gain


Uncommon/Severe Side Effects

  • Extrapyramidal symptoms (EPS), including tardive dyskinesia
  • Neuroleptic malignant syndrome (NMS)
  • Increased risk of suicidal thoughts or actions, particularly in younger patients.


Risks and Warnings of Lurasidone HCl

  • Metabolic Monitoring: Regular monitoring of weight, blood glucose, and lipid levels is advised due to the risk of metabolic side effects.
  • EPS and Tardive Dyskinesia: Monitor for symptoms of EPS and discuss any concerns with your healthcare provider.
  • Elderly Patients: Increased risk of death when used for the treatment of dementia-related psychosis.


Interactions with Lurasidone HCl

Common Drug Interactions

  • CYP450 Enzyme Inhibitors: Medications that inhibit CYP3A4 can increase lurasidone levels and the risk of side effects.
  • Other CNS Depressants: Caution is advised when combining with other medications that can cause sedation, including alcohol, benzodiazepines, and opioids.


Alternatives to Lurasidone HCl

  • Other Atypical Antipsychotics: Such as risperidone, quetiapine, or olanzapine for similar indications.
  • Traditional Antipsychotics: Such as haloperidol for acute management of severe symptoms, although they may have more side effects.