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ARIPiprazole

Aripiprazole is an antipsychotic medication used to treat mental/mood disorders such as bipolar disorder, schizophrenia, Tourette's disorder, and irritability associated with autistic disorder. It can help you to think more clearly, feel less nervous, and take part in everyday life. It can also help to reduce bouts of mood swings, improve concentration, and decrease hallucinations. Common side effects include vomiting, dizziness, sleep issues, or constipation. Your doctor will balance these potential issues against the benefits of taking Aripiprazole.

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Frequently Asked Questions

Can aripiprazole affect my sex drive or performance?
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Though not very common, some people may experience sexual side effects, including a decreased sex drive or performance issues. If this becomes a concern, discuss it with your healthcare provider.

Can elderly people safely use aripiprazole?
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Elderly individuals, especially those with dementiarelated conditions, should exercise caution when taking aripiprazole due to an increased risk of cerebrovascular adverse reactions, including stroke and transient ischemic attack.

Can I take aripiprazole with other medications?
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There is potential for interaction between aripiprazole and other medications. It's best to discuss all your current medications with your doctor or pharmacist before starting aripiprazole.

Does aripiprazole cause weight gain?
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Yes, one of the side effects of aripiprazole is weight gain. But regular exercise and maintaining a healthy diet can help to manage this side effect.

If I'm feeling better, can I stop taking aripiprazole?
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Aripiprazole is a medication that requires regular usage to maintain its effects. If you feel better, consult with your doctor before deciding to stop the medication.

If I'm pregnant, can I take aripiprazole?
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If you are pregnant or considering pregnancy, it's important to discuss the risks and benefits of aripiprazole with your doctor. This is because aripiprazole falls under pregnancy category C meaning that it should only be used if the potential benefit outweighs the potential risk.

Is alcohol safe to consume while on aripiprazole?
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Due to the nature of the medication and the conditions it treats, it's generally recommended to avoid consuming alcohol while taking aripiprazole.

What should I do if I forget a dose?
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If you forget to take a dose of aripiprazole, skip the missed dose and continue on your normal schedule. Never double up on doses.

What should I do if I take too much?
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If you take too much aripiprazole, seek immediate medical attention. Symptoms of overdose may include vomiting, agitation, aggression, confusion, tremors, and reduced consciousness.

Comprehensive Drug Guide

How Does ARIPiprazole Work?

Aripiprazole is an atypical antipsychotic that acts as a partial agonist at certain dopamine and serotonin receptors in the brain, helping to balance out chemical imbalances that lead to psychiatric disorders.

What is ARIPiprazole Used For?

FDA indications: Aripiprazole is used to treat conditions like schizophrenia, bipolar disorder, certain types of depression, and irritability associated with autistic disorder.

Offlabel uses: It's also used in some cases to treat symptoms of dementia, posttraumatic stress disorder, and obsessivecompulsive disorder.

Common Dosages

Tablets: 2mg, 5mg, 10mg, 15mg, 20mg, 30mg

Oral solution: 1mg/mL

Typical Dosing

FDA Approved Indications

  • For FDAapproved indications:
  • Schizophrenia: 10 to 15mg/day initially; can be increased to a maximum of 30mg/day.
  • Bipolar disorder: 15mg/day initially, can be increased to a maximum of 30mg/day.
  • Autismrelated irritability: 515mg/day, depending on body weight and severity.

Off-Label Uses

  • For offlabel uses:
  • PTSD: 2 to 15mg/day.
  • OCD: 10 to 20mg/day.

Who Shouldn't Take ARIPiprazole?

  • Have dementiarelated psychosis.
  • Have a history of neuroleptic malignant syndrome.
  • Have a history of allergic reactions to aripiprazole.
  • Are breastfeeding or planning to become pregnant.
  • Have severe kidney or liver disease.
  • Have heart problems, like heart failure, acquired prolongation of the QT interval, or history of a heart attack.
  • Suffer from dehydration.
  • Have electrolyte imbalance.
  • Have diabetes or are at risk for diabetes.
  • Have swallowing problems.

Advice From The Pharmacist

  • Though rare, aripiprazole has been associated with diabetes and high sugar levels. Regularly check your blood glucose.
  • If you experience any episodes of hyperactivity, restlessness, panic attacks, or thoughts of suicide, consult your doctor immediately.
  • Regular monitoring for abnormal involuntary movements is recommended, especially in pediatric patients.
  • Overheating and dehydration should be avoided.
  • Abrupt withdrawal should be avoided, the medication usually needs to be tapered.

Side Effects of ARIPiprazole

Common Side Effects

  • You might gain weight.
  • You might feel more hungry than usual.
  • You might feel sleepy or fatigued.
  • Dizziness or lightheadedness upon standing.
  • You might experience nausea, vomiting, or constipation

Uncommon/Severe Side Effects

  • Rare side effects:
  • Drop in blood pressure upon standing.
  • High blood sugar levels.
  • Severe allergic reactions.:
  • Agitation, confusion, or other significant changes in mental status.
  • You may experience seizures (though this is very rare).

Risks and Warnings of ARIPiprazole

  • Aripiprazole is not recommended for elderly patients with dementiarelated psychosis. There's an increased risk of death.
  • Using aripiprazole may heighten the risk of suicidal thoughts and actions in children, adolescents, and young adults, especially within the first few months of treatment.
  • Some users have reported experiencing withdrawal symptoms upon stopping the medication suddenly. They include insomnia, restlessness, and mood swings. It's therefore advised to slowly decrease the dosage under the guidance of your healthcare provider.
  • In some rare instances, taking aripiprazole could lead to Neuroleptic Malignant Syndrome (NMS), a serious condition that requires immediate medical attention.
  • Aripiprazole may increase the risk of developing tardive dyskinesia (TD), a condition characterized by uncontrollable muscle movements, often affecting the face.
  • Use with caution for people with a history of seizures, cardiovascular diseases, high blood pressure, paralytic ileus, hematologic diseases, diabetes, or neuroleptic malignant syndrome.
  • High doses or prolonged use of aripiprazole may result in a higher risk of falls among the elderly.
  • Inform your physician if you are pregnant or planning on becoming pregnant. The drug could pose risks to a developing fetus.

Interactions with ARIPiprazole

Common Drug Interactions

  • Alcohol
  • Antidepressants (like Fluoxetine, Paroxetine)
  • Antifungals (like Ketoconazole)
  • Certain antiarrhythmics (like Quinidine)
  • Certain antihistamines (like diphenhydramine)
  • Drugs for high blood pressure or heart disease (like diltiazem, verapamil)
  • HIV protease inhibitors (like Amprenavir, Atazanavir)

Alternatives to ARIPiprazole

  • Risperidone
  • Quetiapine
  • Olanzapine
  • Ziprasidone
  • Clozapine.