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Fluoxetine
Fluoxetine is a medication commonly used to treat depression, anxiety disorders, and certain eating disorders. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs), which work by increasing serotonin levels in the brain. It can help improve mood, reduce anxiety, and restore balance in people's lives.
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Frequently Asked Questions
How long before I start feeling better on fluoxetine?
You're not gonna feel the magic overnight. It usually takes about 4 to 6 weeks to feel the full effect. Don't stress if you don't feel better right away.
Can I have a beer or a glass of wine while taking fluoxetine?
It's best to play it safe and skip the booze. Alcohol can make some of the side effects of fluoxetine, like feeling sleepy or dizzy, even worse.
Can I just stop taking fluoxetine if I feel better?
No. Stopping suddenly can lead to withdrawal symptoms. Always talk to your doctor first if you want to stop.
Can fluoxetine affect my sex drive?
Some people do find that fluoxetine messes with their mojo a bit. If you notice this, don't be shy to talk to your doctor. There are ways to manage this side effect.
Does fluoxetine make you gain weight?
Some folks might gain a bit of weight on fluoxetine, while others don't. If you're worried about weight changes, it's worth chatting with your doc.
Comprehensive Drug Guide
How Does Fluoxetine Work?
Fluoxetine is a Selective Serotonin Reuptake Inhibitor (SSRI). It works by inhibiting the reabsorption of serotonin in the brain, thereby maintaining higher serotonin levels in the synaptic cleft and enhancing neurotransmission.
What is Fluoxetine Used For?
FDA indications: Fluoxetine is primarily used for treating Major Depressive Disorder (MDD), Obsessive-Compulsive Disorder (OCD), Bulimia Nervosa, and Panic Disorder.
Off-label uses: Off-label fluoxetine may be used for the treatment of Premenstrual Dysphoric Disorder (PMDD), Post-Traumatic Stress Disorder (PTSD), and social anxiety disorder.
Common Dosages
Fluoxetine is most commonly manufactured in the following formulations:
Tablets:
- 10mg
- 20mg
- 60mg tablets
Capsules:
- 10mg
- 20mg
- 40mg
Liquid:
- 20mg/5ml
Delays-Release Capsules:
- 90mg delayed-release capsules specifically for the treatment of depression.
Typical Dosing
FDA Approved Indications
MDD: Start with 20mg per day. A maximum dose of 80mg per day may be necessary.
OCD: The typical dose is 20mg to 60mg per day.
Bulimia Nervosa: Typically 60mg per day.
Panic Disorder: Begin with 10mg per day and can increase to a maximum of 60mg per day.
Off-Label Uses
PMDD: Usually start with 20mg per day and adjust as needed.
PTSD: 20mg to 60mg per day.
Social Anxiety Disorder: The standard dose is 20mg to 60mg per day. These dosage suggestions are typical guidelines; however, the patient's doctor will ultimately determine the correct dosage based on individual health status and treatment response.
Pediatric Dosing
For pediatric dosing, please consult the primary care provider first. Here are the standard pediatric dosing by
- For depression or OCD, it's usually 10-20 mg daily to start and can go up to 60 mg daily if needed.
- For bulimia, it's usually 60 mg daily.
- For panic disorder, it starts at 10 mg daily and can go up to 60 mg daily if needed.
Who Shouldn't Take Fluoxetine?
People allergic to fluoxetine or similar medications: If fluoxetine causes you to break out in hives or makes you struggle to breathe, you'll want to skip this one.
Recent MAOI users: If you've used a type of antidepressant called an MAOI in the last two weeks, you can't take fluoxetine. The combo could cause some serious problems.
Glaucoma: If you've got this eye condition, fluoxetine might not be your best bet.
Advice From The Pharmacist
Take it slow: Fluoxetine doesn't work instantly - it can take a few weeks to kick in. So don't stress if you're not feeling 100% right away.
Food is your friend: Try to take fluoxetine with some grub. It helps to keep your tummy from getting upset.
Be consistent: It's essential to take your fluoxetine at the same time each day to keep a steady amount in your body.
Skip the booze: Alcohol can mix badly with fluoxetine, so it's a good idea to avoid drinking while you're taking this medication.
Don't quit cold turkey: If you want to stop taking fluoxetine, talk to your doc first. They'll help you slowly reduce your dose to avoid withdrawal symptoms.
Sexual Life: Fluoxetine can sometimes mess with your sex drive. If this happens, don't be embarrassed to talk to your doctor about it.
Watch for mood changes: If you notice any new or worsening feelings of depression or thoughts of harming yourself, reach out to your healthcare provider right away.
Side Effects of Fluoxetine
Common Side Effects
- Nausea or vomiting
- Trouble sleeping
- Shakiness or nervousness
- Excess sweating
- Losing your appetite
- Diarrhea or constipation
- Changes in sex drive or ability
Uncommon/Severe Side Effects
- Weight changes
Risks and Warnings of Fluoxetine
- If you've taken an MAOI recently, wait at least 14 days before starting fluoxetine to avoid serious serotonin syndrome.
- Watch for worsening depression or anxiety, especially early on or with dose changes. If you have any thoughts of self-harm, contact your doctor immediately.
- Fluoxetine can cause drowsiness or dizziness, so be careful driving or using machinery until you know how it affects you.
- If you have glaucoma, fluoxetine could make it worse. Talk to your doctor about alternatives.
- Don't stop fluoxetine suddenly—work with your doctor to taper off gradually to avoid withdrawal symptoms.
Interactions with Fluoxetine
Common Drug Interactions
- Monoamine oxidase inhibitors (MAOIs), such as selegiline and phenelzine
- Other SSRIs, like citalopram and sertraline
- Serotonin and norepinephrine reuptake inhibitors (SNRIs), like venlafaxine and duloxetine
- Some antipsychotics, like clozapine and thioridazine
- Certain migraine medications, like sumatriptan and zolmitriptan
- Blood thinners, like warfarin
- Pimozide
- Certain heart rhythm medications, like amiodarone and quinidine
Alternatives to Fluoxetine
- Bipolar disorder
- Liver disease
- Kidney disease
- Seizure disorder
- Diabetes
- Glaucoma
- History of drug abuse or suicidal thoughts