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Clozapine
Clozapine is an atypical antipsychotic medication. It is used primarily to treat schizophrenia in patients who have failed to respond to other antipsychotics. Due to certain risks associated with Clozapine use, bloodwork monitoring is necessitated.
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Frequently Asked Questions
Does Clozapine cause weight gain?
Yes, it may cause you to gain weight. Eating a healthy diet and regular exercise can help manage your weight.
What happens if I miss a dose?
If it's close to your next dose, omit the missed dose. If not, take it as soon as you remember. Never double your dose.
Can I stop taking Clozapine on my own?
It's strongly discouraged to stop Clozapine treatment abruptly without consulting with your healthcare provider. This may lead to severe withdrawal symptoms.
What should I do if I have an allergic reaction to Clozapine?
If you experience signs of an allergic reaction, such as hives, difficulty breathing, or swelling of your face, lips, tongue, or throat, seek emergency medical attention.
Can I drink alcohol while taking Clozapine?
It's better to avoid alcohol as it can worsen certain side effects of Clozapine such as drowsiness or dizziness. Always talk with your healthcare provider if you have questions about consuming alcohol during your treatment.
Comprehensive Drug Guide
How Does Clozapine Work?
Clozapine works in the brain, where it affects various neurotransmitters, especially dopamine and serotonin. It's exactly this interference that produces its antipsychotic effects and reduces the incidence of suicidal behavior.
What is Clozapine Used For?
Clozapine is used to treat severe schizophrenia in patients who haven't responded to other medications. It's also proved instrumental in reducing the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorders.
Common Dosages
Tablets: 25mg, 50mg, 100mg, 200mg
Typical Dosing
FDA Approved Indications
- Schizophrenia, Treatment-Resistant: 12.5mg to begin, slowly increasing to a maximum of 900mg/day.
Off-Label Uses
Off-label, it's known to treat psychosis in Parkinson's disease when other treatments fail.
Who Shouldn't Take Clozapine?
- Have a history of Neutropenia/Agranulocytosis
- Have severe Central Nervous System depression or comatose state
- Suffer from bone marrow depression
- Are using other drugs that induce agranulocytosis or bone marrow depression
Advice From The Pharmacist
- Be alert for any signs of fever or infection and report it promptly to the doctor. Clozapine can reduce the number of certain cells in your blood that help fight infections.
- Never stop taking this medication abruptly, it can lead to withdrawal symptoms.
- Try to avoid activities requiring a high level of alertness until Clozapine effect wears off.
- Stay hydrated to avoid constipation, which could be caused by Clozapine.
- Regular blood work is highly important to monitor potential side effects.
- If you experience any unexpected, unusual, or sudden changes in behavior, notify your healthcare provider immediately.
Side Effects of Clozapine
Common Side Effects
- Drowsiness, dizziness, or fainting can happen, so it's better to keep away from activities that require alertness until you are confident that your ability isn't affected.
- You might gain weight.
- You might experience constipation.
- You might experience hypersalivation.
Uncommon/Severe Side Effects
- If you see signs of liver problems like dark urine, or yellowing of eyes/skin.
- Signs of a serious allergic reaction like rash, itching, severe dizziness, swelling, or trouble breathing.
Risks and Warnings of Clozapine
- Clozapine may lower the ability of your body to fight infections. Keep away from people who have infections, and consult with your healthcare provider if you observe symptoms such as fever, sore throat, or chills.
- Clozapine significantly increases the risk of serious and potentially fatality-inducing conditions related to low white blood cells. Constant monitoring of your blood count is pivotal.
Interactions with Clozapine
Common Drug Interactions
- Blood pressure medication
- Sedatives or narcotics
- Antihistamines
- Medications to treat urinary problems
- Other antipsychotics
Alternatives to Clozapine
- Risperidone
- Olanzapine
- Aripiprazole
- Ziprasidone
- Quetiapine
