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diphenhydrAMINE HCl
DiphenhydrAMINE HCl is an antihistamine commonly used to relieve symptoms of allergy, hay fever, and the common cold, such as itching, watery eyes, hives, rashes, sneezing, and runny nose. It also helps prevent and treat nausea, vomiting, and dizziness caused by motion sickness and can be used as a sleep aid. DiphenhydrAMINE belongs to the first-generation antihistamine class, which blocks histamine, a natural substance that your body makes during an allergic reaction.
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Frequently Asked Questions
How long does it take for DiphenhydrAMINE to start working?
It typically takes about 30 minutes for DiphenhydrAMINE to start working for allergy relief or as a sleep aid.
Can I use DiphenhydrAMINE long-term for sleep?
It is not recommended for long-term use as a sleep aid due to the risk of dependence. Consult your doctor for long-term sleep issues.
Is DiphenhydrAMINE safe for children?
Yes, DiphenhydrAMINE is safe for children in specific doses. Always follow dosing recommendations and consult with a doctor before administering it to children under 6 years old.
Can I take DiphenhydrAMINE with alcohol?
No, combining DiphenhydrAMINE with alcohol can increase the risk of severe drowsiness and other side effects.
What should I do if I overdose on DiphenhydrAMINE?
If you suspect an overdose, seek emergency medical attention. Symptoms of overdose may include severe drowsiness, confusion, dry mouth, dilated pupils, and even seizures.
Comprehensive Drug Guide
How Does diphenhydrAMINE HCl Work?
DiphenhydrAMINE HCl works by blocking histamine receptors in the body, reducing the effects of histamine, which causes allergic symptoms. Its sedative properties are due to its ability to cross the blood-brain barrier, leading to drowsiness and promoting sleep in some individuals. It also has anti-nausea properties by affecting the muscarinic receptors in the brain.
What is diphenhydrAMINE HCl Used For?
- Allergic rhinitis (hay fever)
- Cold symptoms
- Motion sickness
- Insomnia (short-term)
- Itching due to insect bites, hives, and rashes
Common Dosages
DiphenhydrAMINE HCl is available in the following forms and strengths:
- Tablets or capsules: 25 mg, 50 mg
- Liquid form: 12.5 mg/5 mL
- Chewable tablets: 12.5 mg
- Topical cream: 1% or 2%
Typical Dosing
FDA Approved Indications
- For allergic reactions: 25 to 50 mg every 4-6 hours for adults; children’s doses vary based on age and weight.
- For motion sickness: 25 to 50 mg taken 30 minutes before travel, then every 4-6 hours.
- For insomnia: 50 mg at bedtime as needed, but not recommended for long-term use.
Off-Label Uses
Pediatric Dosing
- For children older than 6 years, doses vary depending on the condition being treated and the child's weight. Always follow the instructions of a pediatric professional before administering diphenhydramine to children.
- Diphenhydramine is typically not recommended for children under the age of 6.
Who Shouldn't Take diphenhydrAMINE HCl?
DiphenhydrAMINE HCl should not be used in individuals with:
- Known hypersensitivity to diphenhydramine or any component of the formulation
- Severe breathing problems (e.g., emphysema, chronic bronchitis)
- Glaucoma
- Urinary retention
- Use in premature or newborn infants
Advice From The Pharmacist
- DiphenhydrAMINE HCl can cause drowsiness, so avoid driving or operating machinery until you know how it affects you.
- If using this for motion sickness, take it 30 minutes before exposure to prevent symptoms.
- Avoid using alcohol while taking diphenhydramine, as it can increase drowsiness.
- For long-term use as a sleep aid, consult your doctor, as it may cause tolerance and dependence.
Side Effects of diphenhydrAMINE HCl
Common Side Effects
- Drowsiness
- Dizziness
- Dry mouth, nose, or throat
- Blurred vision
Uncommon/Severe Side Effects
- Difficulty urinating
- Severe allergic reactions
- Fast or irregular heartbeat
- Confusion, especially in older adults
Risks and Warnings of diphenhydrAMINE HCl
Sedation Risk: DiphenhydrAMINE can cause significant drowsiness, affecting the ability to drive or operate machinery.
Overuse Risk: Long-term use for sleep can lead to dependence and should be avoided without doctor supervision.
Elderly Caution: The elderly may be more susceptible to confusion, dizziness, and drowsiness. Use with caution in older adults.
Interactions with diphenhydrAMINE HCl
Common Drug Interactions
- CNS depressants: Combining DiphenhydrAMINE with other sedatives (e.g., benzodiazepines) or alcohol can increase drowsiness.
- Anticholinergic drugs: DiphenhydrAMINE can enhance the side effects of other drugs with anticholinergic properties (e.g., medications for Parkinson’s disease).
Common Food Interactions
Alternatives to diphenhydrAMINE HCl
- Loratadine (Claritin): A non-drowsy antihistamine used for allergies.
- Cetirizine (Zyrtec): Another second-generation antihistamine with less sedating effects.
- Meclizine: An antihistamine used to treat motion sickness with less sedation compared to diphenhydramine.
- Doxylamine: A similar first-generation antihistamine often used as a sleep aid.
