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PARoxetine HCl
Paroxetine HCl is a selective serotonin reuptake inhibitor (SSRI) used primarily to treat depression, anxiety disorders, and other related conditions. It helps to increase serotonin levels in the brain, which can improve mood and emotional well-being.
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Frequently Asked Questions
How quickly does Paroxetine HCl work?
Patients may start to notice improvements in symptoms within 2 to 4 weeks, but it may take longer for the full effect to be realized.
Can I take Paroxetine HCl with food?
Yes, it can be taken with or without food, but taking it consistently the same way may help with absorption.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Are there any dietary restrictions while using Paroxetine HCl?
There are no specific dietary restrictions while using Paroxetine HCl.
Is Paroxetine HCl safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Paroxetine HCl during these periods.
Comprehensive Drug Guide
How Does PARoxetine HCl Work?
Paroxetine works by selectively inhibiting the reuptake of serotonin in the brain, leading to increased serotonin levels in the synaptic cleft. This action helps alleviate symptoms of depression and anxiety.
What is PARoxetine HCl Used For?
Common Dosages
- Tablets: Common strengths include 10 mg, 20 mg, 30 mg, and 40 mg.
- Extended-Release Tablets: Available in 12.5 mg, 25 mg, and 37.5 mg.
Typical Dosing
- For depression or anxiety: The usual starting dose is 20 mg taken orally once daily, which may be adjusted based on clinical response, typically ranging from 10 mg to 60 mg daily.
Typical Dosing
FDA Approved Indications
- Major Depressive Disorder: for the treatment of depression in adults.
- Generalized Anxiety Disorder: for the management of anxiety.
- Obsessive-Compulsive Disorder (OCD): for reducing obsessive thoughts and compulsive behaviors.
- Panic Disorder: for the treatment of panic attacks.
- Social Anxiety Disorder: for managing social phobia.
- Post-Traumatic Stress Disorder (PTSD): for treating PTSD symptoms.
Off-Label Uses
Who Shouldn't Take PARoxetine HCl?
- Known hypersensitivity to paroxetine or any component of the formulation.
- Use of monoamine oxidase inhibitors (MAOIs) within the last 14 days.
- Pregnancy (especially in the third trimester due to potential risks to the newborn).
Advice From The Pharmacist
- Take Paroxetine HCl exactly as prescribed; do not stop taking it abruptly without consulting your healthcare provider, as this can lead to withdrawal symptoms.
- It may take several weeks to notice the full therapeutic effects.
- Inform your healthcare provider of any other medications you are taking to avoid potential drug interactions.
Side Effects of PARoxetine HCl
Common Side Effects
- Nausea
- Drowsiness
- Dizziness
- Dry mouth
- Sweating
Uncommon/Severe Side Effects
- Suicidal thoughts or behavior (especially in younger individuals)
- Serotonin syndrome (symptoms include confusion, hallucination, seizures, extreme changes in blood pressure)
- Severe allergic reactions (rash, itching, swelling).
Risks and Warnings of PARoxetine HCl
- Increased Risk of Suicidal Thoughts: Monitor for any worsening mood or emergence of suicidal thoughts, especially in adolescents and young adults.
- Withdrawal Symptoms: Gradually tapering the dose is recommended if discontinuation is necessary to minimize withdrawal effects.
Interactions with PARoxetine HCl
Common Drug Interactions
- Other Antidepressants: Avoid combining with other serotonergic agents due to the risk of serotonin syndrome.
- Blood Thinners: Use with caution as paroxetine can increase the risk of bleeding.
Alternatives to PARoxetine HCl
- Other SSRIs: Such as fluoxetine, sertraline, or citalopram for similar indications.
- SNRIs: Such as venlafaxine or duloxetine for depression and anxiety.
