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Abilify

Abilify, the brand name for aripiprazole, is an antipsychotic medication prescribed to treat a range of mental health conditions, including schizophrenia, bipolar I disorder, and as an adjunctive treatment for major depressive disorder. It is also used in the management of irritability associated with autism spectrum disorder and Tourette’s syndrome. Abilify belongs to a class of medications known as atypical antipsychotics. It helps manage the symptoms of these conditions by balancing certain neurotransmitters in the brain, such as dopamine and serotonin, which can improve mood, thought clarity, and overall stability in behavior.


Abilify is available by prescription in several forms, including tablets, orally disintegrating tablets, oral solution, and intramuscular injections. It can be found at most pharmacies and is prescribed by healthcare providers who specialize in mental health. Abilify is not classified as a controlled substance, meaning it does not have a high potential for abuse or dependence. However, it should still be taken under the supervision of a healthcare provider due to the serious nature of the conditions it treats.


Abilify is formally classified as an atypical antipsychotic, also known as a second-generation antipsychotic. Informally, it may be referred to as a mood stabilizer or antipsychotic. These classifications relate to its purpose of treating mental health conditions by regulating the activity of neurotransmitters in the brain, which helps manage symptoms like mood swings, hallucinations, and irritability.



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Frequently Asked Questions

How long does it take for Abilify to start working?
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Abilify may start to improve symptoms within a few days to a few weeks, but it can take several weeks to experience the full benefits. It’s important to continue taking the medication as prescribed.

What should I do if I miss a dose of Abilify?
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If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. Do not double the dose to make up for the missed one.

Can I drink alcohol while taking Abilify?
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It’s best to avoid alcohol while taking Abilify, as it can increase the sedative effects and potentially worsen side effects like dizziness and drowsiness.

What are the signs of a serious side effect from Abilify?
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Serious side effects may include muscle stiffness, fever, confusion, or uncontrollable movements. If you experience any of these symptoms, seek medical attention immediately.

Can Abilify be used in children?
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Yes, Abilify is approved for use in children and adolescents for certain conditions, such as schizophrenia, bipolar disorder, irritability associated with autism, and Tourette’s syndrome.

Will I gain weight on Abilify?
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Weight gain is a possible side effect of Abilify, particularly with long-term use. It’s important to monitor your weight and discuss any concerns with your healthcare provider.

Comprehensive Drug Guide

How Does Abilify Work?

Abilify works by acting as a partial agonist at dopamine and serotonin receptors in the brain. This means that it helps to stabilize the levels of these neurotransmitters, reducing the overactivity of dopamine that can lead to psychotic symptoms (such as hallucinations) and supporting the underactivity of serotonin that can contribute to mood disorders. By balancing these chemicals, Abilify helps improve mood, reduce psychosis, and stabilize behavior.



What is Abilify Used For?


Common Dosages

Abilify is available in various forms and strengths:

  • Tablets: 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, 30 mg


The specific dosage will depend on the condition being treated and the patient’s response to the medication.


The typical dosing of Abilify varies depending on the condition:

  • Schizophrenia: The recommended starting dose for adults is 10 to 15 mg once daily, with a maintenance dose ranging from 10 to 30 mg per day.
  • Bipolar I Disorder: The initial dose for adults is 15 mg once daily, and the same dose is recommended for pediatric patients aged 10 and older.
  • Major Depressive Disorder: The starting dose as an adjunctive treatment is 2 to 5 mg daily, with a maximum dose of 15 mg per day.
  • Irritability in Autism: The starting dose for children aged 6 to 17 is 2 mg per day, with a target dose of 5 to 15 mg per day.
  • Tourette’s Syndrome: The recommended dose for children aged 6 to 18 is 2 mg per day, with a target dose of 5 to 20 mg per day.

It is important to follow the dosing instructions provided by your healthcare provider, as dosages may be adjusted based on your individual response and tolerance.



Typical Dosing

FDA Approved Indications

Abilify is FDA-approved for the treatment of several conditions, including:

  • Schizophrenia in adults and adolescents aged 13 and older
  • Bipolar I disorder in adults and pediatric patients aged 10 and older (as a monotherapy or adjunct to lithium or valproate)
  • Major depressive disorder in adults (as an adjunct to antidepressants)
  • Irritability associated with autism spectrum disorder in pediatric patients aged 6 and older
  • Tourette’s syndrome in pediatric patients aged 6 and older

Off-label uses may include the treatment of anxiety disorders, obsessive-compulsive disorder (OCD), and other mood disorders, but these uses should be discussed with a healthcare provider.



Off-Label Uses

For off-label uses:

  • PTSD: 2 to 15mg/day.
  • OCD: 10 to 20mg/day.

Who Shouldn't Take Abilify?

Abilify should not be used in individuals who have a known hypersensitivity to aripiprazole or any of the components in the formulation. It should also be used with caution in patients with a history of cardiovascular disease, seizures, or those at risk for metabolic issues such as diabetes. Pregnant or breastfeeding women should discuss the risks and benefits with their healthcare provider before starting this medication.



Advice From The Pharmacist

When taking Abilify, it is important to take it consistently, either with or without food, as directed by your healthcare provider. Avoid alcohol, as it can increase drowsiness and other side effects. If you experience any unusual symptoms, such as muscle stiffness, fever, or uncontrollable movements, contact your healthcare provider immediately. Be sure to inform your healthcare provider of all other medications and supplements you are taking, as interactions can occur. Also, stay hydrated and avoid overheating, as Abilify can affect your body’s ability to regulate temperature.



Side Effects of Abilify

Common Side Effects

Common side effects of Abilify include nausea, vomiting, dizziness, insomnia, and weight gain. More serious side effects, though less common, include tardive dyskinesia (involuntary movements), neuroleptic malignant syndrome (a rare but potentially life-threatening condition characterized by fever and muscle stiffness), and changes in blood sugar levels. If you experience any severe or unusual side effects, seek medical attention immediately.



Uncommon/Severe Side Effects

Rare side effects:

  • Drop in blood pressure upon standing.
  • High blood sugar levels.
  • Severe allergic reactions.:
  • Agitation, confusion, or other significant changes in mental status.
  • You may experience seizures (though this is very rare).

Risks and Warnings of Abilify

The major risks associated with Abilify include an increased risk of metabolic problems, such as weight gain, diabetes, and high cholesterol. There is also a risk of developing movement disorders, such as tardive dyskinesia, particularly with long-term use. Abilify may also increase the risk of suicidal thoughts and behaviors, especially in young adults and children. Regular follow-ups with your healthcare provider are important to monitor for these risks and to ensure that the medication is working effectively.



Interactions with Abilify

Common Drug Interactions

Abilify can interact with other medications, including certain antidepressants, antifungal drugs, and medications that affect heart rhythm. Grapefruit juice may also interact with the medication and should be avoided. It is essential to inform your healthcare provider of all the medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions. Patients with a known allergy to aripiprazole or any of its components should not use this medication.



Alternatives to Abilify

Alternative medications to Abilify include other atypical antipsychotics, such as Risperdal (risperidone), Zyprexa (olanzapine), or Seroquel (quetiapine). Depending on the condition being treated, mood stabilizers like lithium or anticonvulsants like valproate may also be considered. For those with depression, different classes of antidepressants may be tried. It’s important to discuss all options with your healthcare provider to find the best treatment plan for your specific needs.