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Tricor
Tricor (fenofibrate) is a fibrate medication used to lower cholesterol and triglycerides in the blood. It is primarily prescribed to treat hyperlipidemia (high cholesterol) and hypertriglyceridemia (high triglycerides), particularly in patients who are at risk of developing pancreatitis or cardiovascular disease. Tricor works by increasing the natural enzyme that breaks down fats in the blood, leading to a reduction in total cholesterol, LDL (bad cholesterol), triglycerides, and an increase in HDL (good cholesterol).
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Frequently Asked Questions
How long does it take for Tricor to start working?
Tricor typically begins lowering cholesterol and triglyceride levels within a few weeks, but it may take up to two months to see the full effect.
Can I stop taking Tricor if my cholesterol levels improve?
No, Tricor is usually prescribed for long-term use to maintain healthy cholesterol and triglyceride levels. Stopping the medication may cause your levels to rise again. Always consult your doctor before stopping treatment.
Can I take Tricor with food?
Yes, Tricor can be taken with or without food. However, it’s important to take it at the same time each day for consistent absorption.
Is Tricor safe to use with statins?
Tricor can be used with statins, but it increases the risk of muscle damage (rhabdomyolysis). Your doctor will monitor you closely if both medications are prescribed.
Will Tricor cause weight gain?
Weight gain is not a common side effect of Tricor. However, some patients may experience changes in appetite or metabolism. If you notice significant weight changes, consult your healthcare provider.
Comprehensive Drug Guide
How Does Tricor Work?
Fenofibrate works by activating peroxisome proliferator-activated receptor alpha (PPARα), which increases the oxidation of fatty acids in the liver and muscles. This activation reduces triglyceride levels by promoting the breakdown of fats and increases high-density lipoprotein (HDL) while reducing low-density lipoprotein (LDL) and total cholesterol levels. By lowering triglycerides and bad cholesterol, Tricor reduces the risk of heart disease and pancreatitis.
Common Dosages
- 48 mg tablets
- 145 mg tablets
Typical Dosing
- The typical dose for adults with hypercholesterolemia or mixed dyslipidemia is 145 mg once daily, with or without food.
- For individuals with severe hypertriglyceridemia, the starting dose is typically 48 mg to 145 mg once daily based on the patient's response and tolerance.
- Dosage may need adjustment based on renal function and response to the medication.
Typical Dosing
FDA Approved Indications
- Primary hypercholesterolemia or mixed dyslipidemia (elevated LDL-C and total cholesterol)
- Severe hypertriglyceridemia to reduce triglycerides and prevent pancreatitis
Who Shouldn't Take Tricor?
- Severe liver disease (including primary biliary cirrhosis)
- Severe kidney disease
- Gallbladder disease
- Known hypersensitivity to fenofibrate or any of its components
- Nursing mothers (breastfeeding)
Advice From The Pharmacist
- Take Tricor once daily with or without food, as directed by your doctor. Make sure to follow your prescribed diet and exercise plan to get the best results.
- If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose and resume your regular dosing schedule. Do not double up doses.
- Regular blood tests are required to monitor your liver function and lipid levels while taking Tricor, especially in the early stages of treatment.
- Avoid alcohol while taking Tricor, as alcohol can raise triglyceride levels and increase the risk of liver problems.
Side Effects of Tricor
Common Side Effects
- Stomach pain or indigestion
- Nausea or vomiting
- Diarrhea
- Headache
- Muscle pain or weakness
Uncommon/Severe Side Effects
- Liver toxicity (yellowing of the skin or eyes, dark urine, abdominal pain)
- Gallstones
- Pancreatitis (severe upper stomach pain, nausea, vomiting)
- Muscle damage (rhabdomyolysis) with symptoms like muscle pain, tenderness, or weakness, especially when taken with statins
Risks and Warnings of Tricor
- Liver Toxicity: Tricor may cause liver enzyme elevations and, in rare cases, serious liver damage. Regular monitoring of liver function tests is recommended, especially during the initial months of therapy.
- Gallstones: Tricor can increase the risk of developing gallstones due to its effects on fat metabolism. If you experience severe abdominal pain, seek medical attention immediately.
- Muscle Damage (Rhabdomyolysis): Fenofibrate can cause muscle pain or weakness, particularly when used in combination with statins. If you experience unexplained muscle pain, tenderness, or weakness, contact your doctor immediately.
- Kidney Function: Tricor may impair kidney function, particularly in patients with pre-existing kidney conditions. Your doctor may monitor kidney function regularly, especially if you have kidney disease.
Interactions with Tricor
Common Drug Interactions
- Statins (e.g., atorvastatin, simvastatin): Combining fenofibrate with statins can increase the risk of muscle damage (rhabdomyolysis). If both medications are used, careful monitoring is required.
- Warfarin: Fenofibrate may increase the effects of warfarin, leading to a higher risk of bleeding. Close monitoring of blood clotting (INR) is necessary if taking both medications.
- Bile acid sequestrants (e.g., cholestyramine): These medications can decrease the absorption of Tricor. Take Tricor at least 1 hour before or 4 to 6 hours after taking bile acid sequestrants.
- Cyclosporine: Using fenofibrate with cyclosporine may increase the risk of kidney damage. Regular monitoring of kidney function is recommended.
Alternatives to Tricor
- Gemfibrozil (Lopid): Another fibrate used to lower triglycerides and increase HDL cholesterol.
- Atorvastatin (Lipitor): A statin commonly used for lowering LDL cholesterol and total cholesterol.
- Ezetimibe (Zetia): A cholesterol-lowering medication that works by reducing the absorption of cholesterol in the intestines.
- Niacin: A vitamin that can lower cholesterol and triglycerides, although it may cause flushing and other side effects.
