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Ezetimibe
Ezetimibe is a medication used to control high cholesterol levels. It works by reducing the amount of cholesterol that your body absorbs from your diet. Common side effects include diarrhea, fatigue, and joint pain, but your doctor will always weigh these against the benefits of taking it.
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Frequently Asked Questions
Can Ezetimibe cause weight gain?
Weight gain isn't a common side effect of Ezetimibe. However, other factors such as diet and exercise play a significant role in your weight while using this medication.
Can I drink grapefruit juice while taking Ezetimibe?
Grapefruit juice may increase the levels of Ezetimibe in your body. It's better to avoid drinking large amounts of grapefruit juice.
Can I just stop taking Ezetimibe?
Don't stop taking Ezetimibe without consulting your doctor. If you wish to stop the medication, your healthcare provider will help gradually lower the dose to prevent withdrawal effects.
I missed a dose of Ezetimibe. What should I do?
If it's close to your next dose, skip the one you missed and get back on your normal schedule. Otherwise, take it as soon as you remember.
When is the best time to take Ezetimibe?
Ezetimibe can be taken at any time of the day, but try to take it at the same time every day for optimal effectiveness. It can be taken with or without food.
Comprehensive Drug Guide
How Does Ezetimibe Work?
Ezetimibe is a lipidlowering compound that inhibits the intestinal absorption of cholesterol and related phytosterols. By blocking the NiemannPick C1Like 1 (NPC1L1) protein, it reduces the delivery of intestinal cholesterol to the liver.
What is Ezetimibe Used For?
FDA indications: Ezetimibe is primarily used to reduce levels of cholesterol and other fats in the blood, including campesterol and sitosterol.
Offlabel uses: Ezetimibe is also used offlabel to treat homozygous sitosterolemia and homozygous familial hypercholesterolemia.
Common Dosages
Tablets: 10mg
Typical Dosing
FDA Approved Indications
- High cholesterol: 10mg once daily.
Off-Label Uses
- Homozygous Sitosterolemia and Familial Hypercholesterolemia: 10mg daily, often used in combination with statins or fenofibrate.
Who Shouldn't Take Ezetimibe?
- Those who are allergic to Ezetimibe.
- People with liver disease, especially when used with statins.
- Pregnant women or women planning to become pregnant or breastfeeding should consult with their healthcare provider before starting treatment.
- Older adults, as they may be more sensitive to its effects.
Advice From The Pharmacist
- Since Ezetimibe affects the way your body absorbs cholesterol, it's best to take it with a meal.
- Even if you feel well, don't stop taking Ezetimibe without talking to your doctor first.
- You should also maintain a lowfat diet while taking this medication.
- Contact your doctor if you experience severe abdominal pain or yellowing of your skin or eyes.
Side Effects of Ezetimibe
Common Side Effects
- Diarrhea
- Fatigue
- Joint pain
Uncommon/Severe Side Effects
- Rash, itching, severe dizziness, and trouble breathing may be signs of a serious allergic reaction and require immediate medical attention.
Risks and Warnings of Ezetimibe
- Remember that Ezetimibe has potential side effects, and your doctor has considered this in providing you with this medication.
- Do not take Ezetimibe if you have liver disease or if you are allergic to it.
- If you are pregnant, planning to become pregnant, or are breastfeeding, consult with your healthcare provider before starting treatment.
- Older adults may be more sensitive to the side effects of this drug, including muscle problems.
- Frequently monitor liver function tests, and stop the medication if liver injury is suspected.
Interactions with Ezetimibe
Common Drug Interactions
- Bile acid sequestrants (e.g., cholestyramine, colestipol, and colesevelam)
- Fenofibrate
- Statins (e.g., atorvastatin, simvastatin, and rosuvastatin)
- Ciclosporin
Alternatives to Ezetimibe
- Statins (e.g., atorvastatin, rosuvastatin)
- PCSK9 inhibitors (e.g., evolocumab, alirocumab)
- Bile Acid Sequestrants (e.g., cholestyramine, colestipol)
- Fibrates (e.g., fenofibrate, gemfibrozil)
- Nicotinic Acid
