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Fenofibrate

Fenofibrate belongs to a class of medications known as fibrates. It's primarily used in the treatment of high cholesterol and high triglyceride levels. By reducing these levels, it aids in preventing strokes, heart attacks, and other heart-related diseases. Some common side effects can include stomach pain, back pain, and nausea, but your healthcare provider will ensure the benefits outweigh these issues.

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Frequently Asked Questions

Is it safe to take fenofibrate if I have liver disease?
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Generally, it's not recommended for people with liver disease. Fenofibrate can further aggravate the condition. Always consult with your healthcare provider.

Will fenofibrate cause weight gain?
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Weight gain is not a common side effect associated with fenofibrate. However, individual responses may vary.

I missed a dose of fenofibrate, what should I do?
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If it is near the time for your next dose, skip your missed dose. If it's been quite some time since your missed dose, take it as soon as you remember. It's recommended not to take a double dose to make up for it.

Can I just stop taking fenofibrate after my cholesterol levels are under control?
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Not advised. A sudden stoppage of taking fenofibrate could be harmful as cholesterol levels may bounce back. Consult your healthcare provider for advice regarding this.

I have experienced increased muscle pain since I started fenofibrate, is this normal?
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Though not common, it is a possible side effect. This may indicate a more serious condition known as myopathy. Such symptoms should be promptly reported to a healthcare provider.

Comprehensive Drug Guide

How Does Fenofibrate Work?

In college-level language: Fenofibrate is a fibrate that reduces both your liver's production of cholesterol and your blood's volume of triglycerides. It also increases the quantity of high-density lipoproteins - your good cholesterol.

What is Fenofibrate Used For?

FDA indications: Fenofibrate is FDA-approved to reduce cholesterol and triglycerides in the blood.

Off-label use: It's also used off-label to treat high levels of lipoprotein a.

Common Dosages

Tablets and Capsules: 48mg, 67mg, 134mg, 145mg, 160mg, 200mg

Micronized capsules: 67mg, 134mg, 200mg

Typical Dosing

FDA Approved Indications

  • For FDA-approved indications:
  • Cholesterol and Triglycerides: 48 to 145mg per day depending on the specific brand and severity of the condition.

Off-Label Uses

  • For off-label uses:
  • High levels of Lipoprotein a: Dosage will be determined by the healthcare provider.

Who Shouldn't Take Fenofibrate?

  • Those with severe kidney disease, including persons on dialysis.
  • Persons with active liver disease including unexplained and persistent liver function abnormality.
  • Persons with gallbladder disease.
  • Patients with hypersensitivity to fenofibrate.
  • Women who are pregnant, become pregnant or are breastfeeding.

Advice From The Pharmacist

  • Take with food to increase absorption.
  • Fenofibrate can be taken at any time during the day, but taking it at the same time each day helps to ensure even coverage and enhances its beneficial effects.
  • Even while taking fenofibrate, continue your diet of lower-fat foods. A good diet can help lower cholesterol even further.
  • Inform your healthcare provider if you experience rash, muscle pain, or yellowing of the skin.
  • Regular checkups to monitor your progress and detect any unwanted side effects are recommended.
  • Patients should also be aware that this drug may increase the risk of gallstones.

Side Effects of Fenofibrate

Common Side Effects

  • Stomach pain
  • Back pain
  • Headache
  • Nausea

Uncommon/Severe Side Effects

  • Rare side effects:
  • Yellowing of the skin or eyes
  • Dark urine
  • Unusual tiredness
  • Severe stomach/abdominal pain
  • Severe side effects:
  • If you experience signs of a strong allergic reaction, such as difficulty breathing or chest pain, seek emergency medical help.

Risks and Warnings of Fenofibrate

  • Fenofibrate should be avoided by individuals with severe kidney disease and those with active liver disease.
  • Persons with underlying gallbladder issues should also avoid the drug, as it can worsen the condition.
  • Women who are pregnant, trying to get pregnant, or breastfeeding should consult with their healthcare provider, as safety in these conditions has not yet been confirmed.
  • Like other fibrates, fenofibrate may increase cholesterol excretion into the bile, leading to cholelithiasis (gallstones).
  • In rare cases, fenofibrate can cause muscle problems (myopathy) leading to kidney damage. Be sure to seek medical advice if you experience muscle pain, weakness, or tenderness.

Interactions with Fenofibrate

Common Drug Interactions

  • Blood thinners
  • Certain diabetes medications
  • Other cholesterol-reducing drugs
  • Immunosuppressants
  • Colchicine

Alternatives to Fenofibrate

  • Gemfibrozil
  • Atorvastatin
  • Simvastatin
  • Pravastatin
  • Lovastatin