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Colchicine
Colchicine is a traditional medication used to prevent and treat gout attacks. It helps to reduce gout symptoms by decreasing the buildup of uric acid crystals in your body that cause pain in your affected and inflamed joints. It's also used in the treatment of Mediterranean fever. Remember, while it helps prevent gout attacks, it does not cure gout or lower the amount of uric acid in the body. Certain common side effects may feature but typically, they are minor and the benefits that Colchicine brings to the table are substantial.
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Frequently Asked Questions
Can I take Colchicine during an active gout attack?
Yes, it's most effective when taken at the first sign of a gout attack.
Can I take this if I have kidney problems?
Your doctor may have to adjust the dose or frequency if you have kidney problems. It's crucial to be transparent about your full medical history.
I missed a dose, what should I do?
If it's near the time for the next dose, skip it and go back to your regular schedule. Contrarily, if there's plenty of time, take it as soon as you remember. Do not double dose.
Will I experience withdrawal symptoms if I stop?
There may not be withdrawal symptoms, but it's recommended to follow a doctor's advice on stopping any medication.
Will it affect my mood?
Colchicine doesn't typically affect mood but monitor any changes and report to your doctor.
Comprehensive Drug Guide
How Does Colchicine Work?
Colchicine works by diminishing white blood cell activity, reducing inflammation, and lessening the buildup of lactic acid crystals that cause gout symptoms.
What is Colchicine Used For?
FDA indications: Colchicine treats gout and prevents recurrent gout flareups. It also handles symptoms of Mediterranean fever, a genetic inflammatory disorder.
Offlabel uses: Although offlabel, it's also used to treat patients with pericarditis, an inflammation of the pericardium around the heart.
Common Dosages
Tablets: 0.6mg
Oral solution: Not available
Intravenous: Not available
Typical Dosing
FDA Approved Indications
- Acute gout flare: Two tablets at the first sign of the flare followed by one tablet one hour later.
- Prevention of gout flares and treatment of Familial Mediterranean Fever: 1.2mg to 2.4mg daily.
Off-Label Uses
- Acute pericarditis: 1.2mg followed by 0.6mg every hour or 0.6mg every two hours until relief.
Who Shouldn't Take Colchicine?
- Have blood disorders or are on other medications that affect the blood.
- Have liver or kidney problems.
- Are pregnant, planning to become pregnant, or breastfeeding.
- Have a stomach disorder or other digestive issues.
- Are allergic to Colchicine or other ingredients in the medication.
- Have heart problems.
Advice From The Pharmacist
- Keep a list of all your medications, and share the list with your doctor and pharmacist.
- Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely.
- Don't increase or decrease the dose or discontinue the medication without consulting your doctor.
- Keep all medical and lab appointments.
- Selfcare is important. Ensure regular doctor consultations to monitor your condition.
Side Effects of Colchicine
Common Side Effects
- Common Side Effects
- Gastrointestinal troubles like diarrhea and nausea might trouble you.
- You could fall prey to abdominal pain.
- Rare Side Effects
- Neuromuscular toxicity and rhabdomyolysis.
- Severe Side Effects
- Allergic reactions with manifestations of rash, swelling, or difficulty breathing.
Risks and Warnings of Colchicine
- Follow the dosing directions exactly. The buildup of Colchicine in the body could cause serious side effects.
- Limit alcohol intake ? it can increase your risk of stomach bleeding.
- Certain foods may influence the effect of Colchicine. Stick to a balanced diet and keep your doctor informed about your food habits.
- People with liver, kidney, and heart problems, as well as those suffering from certain blood disorders, need to approach this medication with caution.
- Pregnant women and breastfeeding mothers are advised to avoid this drug.
Interactions with Colchicine
Common Drug Interactions
- Cyclosporine
- Digoxin
- Pravastatin
- Atorvastatin
- Clarithromycin
Alternatives to Colchicine
- Allopurinol
- Febuxostat
- Probenecid
- Pegloticase
- Rasburicase
