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Gemfibrozil
Gemfibrozil is a lipidlowering medication. It's used primarily to reduce cholesterol and triglyceride levels in people with pancreatitis or other conditions. Some common side effects include stomach pain, diarrhea, and feeling tired, but your doctor will typically ensure that the benefits outweigh these issues.
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Frequently Asked Questions
Can I combine Gemfibrozil with statins?
Gemfibrozil can be combined with some statins, but it increases the risk of muscle damage or myopathy. Always consult your doctor.
Can I take Gemfibrozil if I have liver disease?
No, Gemfibrozil is not recommended if you have severe liver disease as it can worsen your condition.
Can I take Gemfibrozil with a meal?
Yes, you should take Gemfibrozil with meals to increase its absorption.
How long does it take Gemfibrozil to work?
It could take several weeks to months before you see the full benefits of this drug. It's important to continue taking Gemfibrozil even if you feel well. Do not stop taking the medication without talking to your doctor.
Comprehensive Drug Guide
How Does Gemfibrozil Work?
Gemfibrozil works by reducing the production of triglycerides in the liver and also speeds up the removal of these fats from the blood.
What is Gemfibrozil Used For?
FDA indications: Gemfibrozil is used primarily to lower cholesterol and triglycerides in people with pancreatitis and to prevent cardiovascular disease in people at high risk.
Offlabel uses: It's also been used for the offlabel treatment of statinassociated muscle symptoms.
Common Dosages
Tablets: 600mg
Typical Dosing
FDA Approved Indications
- High cholesterol and triglycerides: 600mg twice a day.
Off-Label Uses
- Statinassociated muscle symptoms: Depends on the severity of the condition and will be determined by the healthcare provider.
Who Shouldn't Take Gemfibrozil?
- Have severe renal and liver disease.
- Have a preexisting gallbladder disease.
- Are pregnant or planning to conceive or are breastfeeding.
- Have hypersensitivity to Gemfibrozil or any inactive component of this drug.
- Have known photoallergic or phototoxic reactions to fibrates.
- Are under treatment with Repaglinide.
Advice From The Pharmacist
- Always take Gemfibrozil with meals to increase its absorption.
- Follow a lipidlowering diet to maximize the benefits of this medication. Regular exercise also helps.
- Bless your liver! Avoid alcohol as it can increase the risk of liver damage.
- Maintain regular checkups with your healthcare provider to adjust dosages if necessary.
- Don't quit taking it abruptly. Always consult your doctor about cessation or your dosage.
- Stay hydrated and keep your kidneys in mind, as Gemfibrozil can affect their function.
Side Effects of Gemfibrozil
Common Side Effects
- Stomach pain or cramps.
- Drowsiness or dizziness.
- Experiencing diarrhea.
Uncommon/Severe Side Effects
- Joint or muscle pain.
- Severe dermatologic reactions.
Risks and Warnings of Gemfibrozil
- Gemfibrozil isn't recommended for folks with severe liver, renal, or gallbladder disease.
- Pregnancy and breastfeeding require caution? it's not clear whether Gemfibrozil harms the baby. Always consult a healthcare provider.
- Certain drug interactions, for instance with Repaglinide, are critical and must be avoided.
- Risk of myopathy may be increased when combined with statins.
- It may increase cholesterol excretion into the bile, leading to gallstones.
Interactions with Gemfibrozil
Common Drug Interactions
- Warfarin
- Atorvastatin
- Rosuvastatin
- Repaglinide
- Bexarotene
- Ezetimibe
Alternatives to Gemfibrozil
- Fenofibrate
- Atorvastatin
- Rosuvastatin
- Pravastatin
- Simvastatin
