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Colesevelam HCl

Colesevelam HCl is a bile acid sequestrant primarily used to lower cholesterol levels in individuals with hyperlipidemia and to improve glycemic control in patients with type 2 diabetes. It works by binding to bile acids in the intestine, preventing their reabsorption and promoting their excretion. This process helps lower the amount of cholesterol circulating in the blood. Colesevelam HCl is often prescribed as part of a cholesterol-lowering treatment plan that includes a healthy diet and exercise.



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Frequently Asked Questions

How long does it take for Colesevelam HCl to work?
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You may start to see improvements in cholesterol levels within a few weeks of starting treatment. Full effects on cholesterol and blood sugar control may take up to 4 to 6 weeks.

Can I take Colesevelam HCl with other cholesterol-lowering medications?
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Yes, Colesevelam can be used alongside other cholesterol-lowering medications, such as statins, for improved cholesterol management. However, take medications like statins at least 4 hours apart from Colesevelam to avoid absorption issues.

Can Colesevelam HCl be used for weight loss?
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Colesevelam is not approved for weight loss, though some patients may experience modest weight reduction due to its effects on fat absorption and metabolism.

Is Colesevelam HCl safe during pregnancy?
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Colesevelam HCl is generally considered safe during pregnancy because it is not absorbed systemically. However, you should consult your healthcare provider before taking any medication during pregnancy.

What should I do if I miss a dose of Colesevelam?
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If you miss a dose, take it as soon as you remember. If it’s close to the time of your next dose, skip the missed dose and continue your regular schedule. Do not double the dose to make up for the missed one.

Comprehensive Drug Guide

How Does Colesevelam HCl Work?

Colesevelam works by binding to bile acids in the intestines, forming an insoluble complex that is excreted in the stool. Bile acids are made from cholesterol, and their loss stimulates the liver to use more cholesterol to produce more bile acids, lowering the amount of cholesterol in the bloodstream. It also has a secondary effect of improving glycemic control in patients with type 2 diabetes, though the exact mechanism is not fully understood.

What is Colesevelam HCl Used For?


Common Dosages

  • Tablets: 625 mg
  • Powder for oral suspension: 3.75 grams per packet

Typical Dosing

  • For lowering cholesterol: The recommended dose is 3.75 grams per day, which can be taken as six 625 mg tablets daily or one packet of powder mixed with water. This can be divided into two doses.
  • For type 2 diabetes: The recommended dose is the same as for lowering cholesterol. It can be taken with meals to improve effectiveness.

Typical Dosing

FDA Approved Indications

  • Lowering low-density lipoprotein (LDL) cholesterol in patients with primary hyperlipidemia
  • Improving glycemic control in adults with type 2 diabetes (in combination with other antidiabetic medications)


Who Shouldn't Take Colesevelam HCl?

  • Known hypersensitivity to colesevelam or any component of the formulation
  • Bowel obstruction
  • High triglycerides (over 500 mg/dL) due to the risk of worsening hypertriglyceridemia
  • History of pancreatitis due to elevated triglycerides


Advice From The Pharmacist

  • Take Colesevelam HCl with meals to increase its effectiveness in lowering cholesterol and improving blood sugar control.
  • If taking the powder form, mix the contents of the packet with water or other liquids as directed before drinking. Do not take the powder dry.
  • Colesevelam may interfere with the absorption of other medications. Take other medications at least 4 hours before or after taking Colesevelam to avoid interactions.
  • Maintain a balanced diet and regular exercise routine to optimize cholesterol and glucose control while taking Colesevelam.


Side Effects of Colesevelam HCl

Common Side Effects

  • Constipation
  • Nausea or upset stomach
  • Indigestion
  • Flatulence
  • Headache


Uncommon/Severe Side Effects

  • Severe constipation or bowel obstruction
  • High triglycerides, which can lead to pancreatitis
  • Hypoglycemia (in patients with diabetes)


Risks and Warnings of Colesevelam HCl

  • Bowel Obstruction: Colesevelam can cause or worsen constipation, especially in patients with a history of bowel issues. If you experience severe constipation, abdominal pain, or bloating, discontinue the medication and seek medical advice.
  • Hypertriglyceridemia: Colesevelam may raise triglyceride levels in some patients. Regular monitoring of lipid levels is recommended, especially in patients with a history of high triglycerides.
  • Drug Interactions: Colesevelam can reduce the absorption of certain medications, including fat-soluble vitamins (A, D, E, and K), thyroid medications, and certain diabetes drugs. Be sure to take these medications at a different time than Colesevelam.

Interactions with Colesevelam HCl

Common Drug Interactions

  • Fat-soluble vitamins (A, D, E, K): Colesevelam may reduce the absorption of these vitamins. If taking a multivitamin, take it at least 4 hours before or after Colesevelam.
  • Thyroid medications (levothyroxine): Colesevelam can interfere with the absorption of thyroid medications. Separate administration times are recommended.
  • Oral contraceptives: Colesevelam may reduce the effectiveness of oral contraceptives by reducing absorption. Use an alternative or additional method of birth control while taking Colesevelam.
  • Diabetes medications (metformin, glipizide): Colesevelam may affect the absorption of certain diabetes medications. Blood glucose levels should be monitored closely.

Alternatives to Colesevelam HCl

  • Cholestyramine (Questran): Another bile acid sequestrant used to lower cholesterol, but it may have more gastrointestinal side effects.
  • Ezetimibe (Zetia): A cholesterol absorption inhibitor that works differently by blocking cholesterol absorption in the intestines.
  • Statins (Atorvastatin, Simvastatin): Commonly prescribed to lower LDL cholesterol and reduce the risk of heart disease.
  • Fenofibrate (Tricor): A lipid-lowering medication often used in patients with high triglycerides.