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Treximet
Treximet is a combination medication that contains sumatriptan (a triptan) and naproxen sodium (a nonsteroidal anti-inflammatory drug or NSAID) used to treat migraine attacks in adults. Sumatriptan helps to relieve the headache by narrowing the blood vessels around the brain, while naproxen reduces pain and inflammation. Together, they work to alleviate both the pain and associated symptoms of migraines, such as light sensitivity, nausea, and throbbing pain. It is not used to prevent migraines or reduce the frequency of attacks.
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Frequently Asked Questions
How quickly does Treximet work?
Treximet typically starts to relieve migraine symptoms within 30 minutes to an hour after taking the first dose.
Can I take Treximet for a tension headache or other types of pain?
No, Treximet is specifically designed to treat migraines and should not be used for other types of headaches, such as tension or cluster headaches.
Can I take more than one Treximet tablet if my migraine doesn’t go away?
You can take a second dose if your migraine persists after 2 hours, but do not exceed more than two doses in a 24-hour period.
Is Treximet safe to use with other migraine medications?
You should avoid using Treximet with other triptans or NSAIDs. Always consult your doctor before combining it with other medications.
Can I drive after taking Treximet?
Treximet may cause dizziness or drowsiness, so it's best to avoid driving or operating heavy machinery until you know how it affects you.
Comprehensive Drug Guide
How Does Treximet Work?
- Sumatriptan works by stimulating serotonin (5-HT1) receptors in the brain, causing the blood vessels to constrict, which relieves migraine headaches.
- Naproxen sodium reduces the production of prostaglandins, substances that cause inflammation and pain, helping to alleviate headache-related discomfort and inflammation.
Common Dosages
- Oral tablets containing 85 mg sumatriptan and 500 mg naproxen sodium.
Typical Dosing
- The typical dose for adults and children aged 12 years and older is one tablet at the onset of a migraine attack. If the migraine persists, a second dose may be taken after 2 hours, but no more than two doses should be taken in a 24-hour period.
Typical Dosing
FDA Approved Indications
- Acute treatment of migraine attacks with or without aura in adults and children aged 12 years and older.
Who Shouldn't Take Treximet?
- Coronary artery disease (CAD)
- Uncontrolled high blood pressure
- History of stroke or transient ischemic attack (TIA)
- Severe liver disease
- Known hypersensitivity to sumatriptan, naproxen, or any other components of the formulation
Advice From The Pharmacist
- Take Treximet as soon as you notice the symptoms of a migraine. Do not take it for any other type of headache or pain.
- Avoid taking more than two doses within 24 hours to prevent potential side effects.
- Stay hydrated while taking Treximet, as dehydration can worsen headache symptoms.
- If you have a history of heart disease or risk factors like high blood pressure, talk to your doctor before using this medication.
- Treximet may increase the risk of stomach ulcers or bleeding, especially if used long-term or combined with alcohol or other NSAIDs.
Side Effects of Treximet
Common Side Effects
- Dizziness
- Drowsiness
- Nausea
- Dry mouth
- Fatigue
Uncommon/Severe Side Effects
- Heart attack or stroke
- Severe allergic reactions (swelling of the face, throat, or rash)
- Stomach bleeding or ulcers
- Serotonin syndrome (with symptoms like agitation, hallucinations, or rapid heartbeat)
Risks and Warnings of Treximet
- Cardiovascular Risk: Sumatriptan can constrict blood vessels, which may increase the risk of heart attack or stroke, especially in patients with heart disease or risk factors for cardiovascular problems.
- Gastrointestinal Bleeding: Naproxen, as an NSAID, may cause stomach bleeding, ulcers, or perforation, particularly in patients with a history of gastrointestinal issues or those using it long-term.
- Serotonin Syndrome: Treximet, when used with certain antidepressants, can increase the risk of serotonin syndrome. Seek immediate medical attention if symptoms like confusion, sweating, or rapid heart rate occur.
Interactions with Treximet
Common Drug Interactions
- SSRIs/SNRIs: Combining Treximet with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) can increase the risk of serotonin syndrome.
- Blood thinners: Using Treximet with blood thinners like warfarin or aspirin may increase the risk of bleeding.
- Other NSAIDs: Avoid using additional NSAIDs (like ibuprofen) while taking Treximet to prevent the risk of stomach ulcers or gastrointestinal bleeding.
Alternatives to Treximet
- Rizatriptan (Maxalt): Another triptan used for the acute treatment of migraines.
- Sumatriptan (Imitrex): Available without naproxen, used alone for migraines.
- Naratriptan (Amerge): Another triptan option that works similarly to sumatriptan but may have a longer-lasting effect.
- Frovatriptan (Frova): Another triptan known for its longer duration of action.
